Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer
Abstract Purpose We evaluated the clinical significance of angiopoietins and vascular endothelial growth factor (VEGF) in patients with resected early stage lung cancer. Patients and methods The study enrolled 101 patients with completely resected non-small cell lung cancer (NSCLC) of stage I or II,...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2009-12, Vol.66 (3), p.359-364 |
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| creator | Park, Joo Hun Choi, Ho Kim, Young Bae Kim, Young Sun Sheen, Seung Soo Choi, Jin-Hyuk Lee, Hye Lim Lee, Keu Sung Chung, Woo Young Lee, Sungsoo Park, Kyung Joo Hwang, Sung Chul Lee, Kyi Beum Park, Kwang Joo |
| description | Abstract Purpose We evaluated the clinical significance of angiopoietins and vascular endothelial growth factor (VEGF) in patients with resected early stage lung cancer. Patients and methods The study enrolled 101 patients with completely resected non-small cell lung cancer (NSCLC) of stage I or II, along with 70 healthy volunteers. Serum concentrations of angiopoietin-1, angiopoietin-2, and VEGF were measured with an ELISA. Immunohistochemical expression of angiopoietin-1 was compared with the microvessel density on the lung cancer tissues. Results The patients had lower serum angiopoietin-1 (32.1 ± 9.9 ng/mL vs. 39.0 ± 10.8 ng/mL, p < 0.001), higher angiopoietin-2 (1949.2 ± 1099.4 pg/mL vs. 1498.6 ± 650.0 pg/mL, p < 0.01), and higher VEGF (565.1 ± 406.3 pg/mL vs. 404.6 ± 254.8 pg/mL, p < 0.01) levels than the controls. The angiopoietin-2 level was higher in stage II than in stage I patients ( p < 0.05). The levels of angiopoietin-1 ( r = 0.28) and angiopoietin-2 ( r = 0.36) each correlated with the VEGF level. Patients with a higher level of angiopoietin-1 (≥31.2 ng/mL) had better disease-specific and relapse-free survival than those with a lower angiopoietin-1 level ( |
| doi_str_mv | 10.1016/j.lungcan.2009.03.002 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733182557</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0169500209001263</els_id><sourcerecordid>733182557</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-c29a4153709ec780a23ac6e8e620a17249b0aab2c7a3cf0f5965b5d9822a3d643</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7rj6E5RcxFO3lWTS6VyUZfELFvaweg416eohsz3pMekW5t-bZhoFL54C4amqt55i7LWAWoBo3h_qYY57j7GWALYGVQPIJ2wjWiOrVin5lG0KZytd_q_Yi5wPAMIIsM_ZlbBKWTBmw-4fKM1HjnEfxtMYaAqxEhwzR35K4z6OeQqeHzE9UuIh8kSZ_EQdJ0zDmecJ98SXJLxE8ZResmc9Dplere81-_H50_fbr9Xd_Zdvtzd3lddCT5WXFrdCKwOWvGkBpULfUEuNBBRGbu0OEHfSG1S-h17bRu90Z1spUXXNVl2zd5e-JeXPmfLkjiF7GgaMNM7ZGaVEK7U2hdQX0qcx50S9O6VQFjo7AW5R6Q5uVekWlQ6UK8pK3Zt1wrw7Uve3anVXgLcrgNnj0KciIOQ_nJRlP91A4T5eOCo-fgVKLvtARVYXUnHpujH8N8qHfzr4IcRQhj7SmfJhnFMssp1wWTpwD8vdl7ODLSeXjVK_Abv5qJE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733182557</pqid></control><display><type>article</type><title>Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Park, Joo Hun ; Choi, Ho ; Kim, Young Bae ; Kim, Young Sun ; Sheen, Seung Soo ; Choi, Jin-Hyuk ; Lee, Hye Lim ; Lee, Keu Sung ; Chung, Woo Young ; Lee, Sungsoo ; Park, Kyung Joo ; Hwang, Sung Chul ; Lee, Kyi Beum ; Park, Kwang Joo</creator><creatorcontrib>Park, Joo Hun ; Choi, Ho ; Kim, Young Bae ; Kim, Young Sun ; Sheen, Seung Soo ; Choi, Jin-Hyuk ; Lee, Hye Lim ; Lee, Keu Sung ; Chung, Woo Young ; Lee, Sungsoo ; Park, Kyung Joo ; Hwang, Sung Chul ; Lee, Kyi Beum ; Park, Kwang Joo</creatorcontrib><description>Abstract Purpose We evaluated the clinical significance of angiopoietins and vascular endothelial growth factor (VEGF) in patients with resected early stage lung cancer. Patients and methods The study enrolled 101 patients with completely resected non-small cell lung cancer (NSCLC) of stage I or II, along with 70 healthy volunteers. Serum concentrations of angiopoietin-1, angiopoietin-2, and VEGF were measured with an ELISA. Immunohistochemical expression of angiopoietin-1 was compared with the microvessel density on the lung cancer tissues. Results The patients had lower serum angiopoietin-1 (32.1 ± 9.9 ng/mL vs. 39.0 ± 10.8 ng/mL, p < 0.001), higher angiopoietin-2 (1949.2 ± 1099.4 pg/mL vs. 1498.6 ± 650.0 pg/mL, p < 0.01), and higher VEGF (565.1 ± 406.3 pg/mL vs. 404.6 ± 254.8 pg/mL, p < 0.01) levels than the controls. The angiopoietin-2 level was higher in stage II than in stage I patients ( p < 0.05). The levels of angiopoietin-1 ( r = 0.28) and angiopoietin-2 ( r = 0.36) each correlated with the VEGF level. Patients with a higher level of angiopoietin-1 (≥31.2 ng/mL) had better disease-specific and relapse-free survival than those with a lower angiopoietin-1 level (<31.2 ng/mL). Angiopoietin-1 expression negatively correlated with the microvessel density. Conclusion Serum angiopoietin-1 is a potential marker for predicting postoperative survival and recurrence in patients with early stage NSCLC.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2009.03.002</identifier><identifier>PMID: 19339077</identifier><identifier>CODEN: LUCAE5</identifier><language>eng</language><publisher>Oxford: Elsevier Ireland Ltd</publisher><subject>Aged ; Angiopoietin-1 ; Angiopoietin-1 - biosynthesis ; Angiopoietin-1 - blood ; Angiopoietin-1 - genetics ; Angiopoietin-2 - blood ; Biological and medical sciences ; Biomarkers, Tumor - blood ; Carcinoma, Non-Small-Cell Lung - blood ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - physiopathology ; Disease-Free Survival ; Early stage ; Enzyme-Linked Immunosorbent Assay ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Lung - metabolism ; Lung - pathology ; Lung Neoplasms - blood ; Lung Neoplasms - diagnosis ; Lung Neoplasms - pathology ; Lung Neoplasms - physiopathology ; Male ; Medical sciences ; Microvessels - pathology ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Non-small cell lung cancer ; Pneumology ; Prognosis ; Pulmonary/Respiratory ; Survival ; Tumors ; Tumors of the respiratory system and mediastinum ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2009-12, Vol.66 (3), p.359-364</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-c29a4153709ec780a23ac6e8e620a17249b0aab2c7a3cf0f5965b5d9822a3d643</citedby><cites>FETCH-LOGICAL-c515t-c29a4153709ec780a23ac6e8e620a17249b0aab2c7a3cf0f5965b5d9822a3d643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lungcan.2009.03.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22153560$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19339077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Joo Hun</creatorcontrib><creatorcontrib>Choi, Ho</creatorcontrib><creatorcontrib>Kim, Young Bae</creatorcontrib><creatorcontrib>Kim, Young Sun</creatorcontrib><creatorcontrib>Sheen, Seung Soo</creatorcontrib><creatorcontrib>Choi, Jin-Hyuk</creatorcontrib><creatorcontrib>Lee, Hye Lim</creatorcontrib><creatorcontrib>Lee, Keu Sung</creatorcontrib><creatorcontrib>Chung, Woo Young</creatorcontrib><creatorcontrib>Lee, Sungsoo</creatorcontrib><creatorcontrib>Park, Kyung Joo</creatorcontrib><creatorcontrib>Hwang, Sung Chul</creatorcontrib><creatorcontrib>Lee, Kyi Beum</creatorcontrib><creatorcontrib>Park, Kwang Joo</creatorcontrib><title>Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>Abstract Purpose We evaluated the clinical significance of angiopoietins and vascular endothelial growth factor (VEGF) in patients with resected early stage lung cancer. Patients and methods The study enrolled 101 patients with completely resected non-small cell lung cancer (NSCLC) of stage I or II, along with 70 healthy volunteers. Serum concentrations of angiopoietin-1, angiopoietin-2, and VEGF were measured with an ELISA. Immunohistochemical expression of angiopoietin-1 was compared with the microvessel density on the lung cancer tissues. Results The patients had lower serum angiopoietin-1 (32.1 ± 9.9 ng/mL vs. 39.0 ± 10.8 ng/mL, p < 0.001), higher angiopoietin-2 (1949.2 ± 1099.4 pg/mL vs. 1498.6 ± 650.0 pg/mL, p < 0.01), and higher VEGF (565.1 ± 406.3 pg/mL vs. 404.6 ± 254.8 pg/mL, p < 0.01) levels than the controls. The angiopoietin-2 level was higher in stage II than in stage I patients ( p < 0.05). The levels of angiopoietin-1 ( r = 0.28) and angiopoietin-2 ( r = 0.36) each correlated with the VEGF level. Patients with a higher level of angiopoietin-1 (≥31.2 ng/mL) had better disease-specific and relapse-free survival than those with a lower angiopoietin-1 level (<31.2 ng/mL). Angiopoietin-1 expression negatively correlated with the microvessel density. Conclusion Serum angiopoietin-1 is a potential marker for predicting postoperative survival and recurrence in patients with early stage NSCLC.</description><subject>Aged</subject><subject>Angiopoietin-1</subject><subject>Angiopoietin-1 - biosynthesis</subject><subject>Angiopoietin-1 - blood</subject><subject>Angiopoietin-1 - genetics</subject><subject>Angiopoietin-2 - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoma, Non-Small-Cell Lung - blood</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - physiopathology</subject><subject>Disease-Free Survival</subject><subject>Early stage</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microvessels - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Non-small cell lung cancer</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Pulmonary/Respiratory</subject><subject>Survival</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6E5RcxFO3lWTS6VyUZfELFvaweg416eohsz3pMekW5t-bZhoFL54C4amqt55i7LWAWoBo3h_qYY57j7GWALYGVQPIJ2wjWiOrVin5lG0KZytd_q_Yi5wPAMIIsM_ZlbBKWTBmw-4fKM1HjnEfxtMYaAqxEhwzR35K4z6OeQqeHzE9UuIh8kSZ_EQdJ0zDmecJ98SXJLxE8ZResmc9Dplere81-_H50_fbr9Xd_Zdvtzd3lddCT5WXFrdCKwOWvGkBpULfUEuNBBRGbu0OEHfSG1S-h17bRu90Z1spUXXNVl2zd5e-JeXPmfLkjiF7GgaMNM7ZGaVEK7U2hdQX0qcx50S9O6VQFjo7AW5R6Q5uVekWlQ6UK8pK3Zt1wrw7Uve3anVXgLcrgNnj0KciIOQ_nJRlP91A4T5eOCo-fgVKLvtARVYXUnHpujH8N8qHfzr4IcRQhj7SmfJhnFMssp1wWTpwD8vdl7ODLSeXjVK_Abv5qJE</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Park, Joo Hun</creator><creator>Choi, Ho</creator><creator>Kim, Young Bae</creator><creator>Kim, Young Sun</creator><creator>Sheen, Seung Soo</creator><creator>Choi, Jin-Hyuk</creator><creator>Lee, Hye Lim</creator><creator>Lee, Keu Sung</creator><creator>Chung, Woo Young</creator><creator>Lee, Sungsoo</creator><creator>Park, Kyung Joo</creator><creator>Hwang, Sung Chul</creator><creator>Lee, Kyi Beum</creator><creator>Park, Kwang Joo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer</title><author>Park, Joo Hun ; Choi, Ho ; Kim, Young Bae ; Kim, Young Sun ; Sheen, Seung Soo ; Choi, Jin-Hyuk ; Lee, Hye Lim ; Lee, Keu Sung ; Chung, Woo Young ; Lee, Sungsoo ; Park, Kyung Joo ; Hwang, Sung Chul ; Lee, Kyi Beum ; Park, Kwang Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-c29a4153709ec780a23ac6e8e620a17249b0aab2c7a3cf0f5965b5d9822a3d643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Angiopoietin-1</topic><topic>Angiopoietin-1 - biosynthesis</topic><topic>Angiopoietin-1 - blood</topic><topic>Angiopoietin-1 - genetics</topic><topic>Angiopoietin-2 - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoma, Non-Small-Cell Lung - blood</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - physiopathology</topic><topic>Disease-Free Survival</topic><topic>Early stage</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microvessels - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Non-small cell lung cancer</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Pulmonary/Respiratory</topic><topic>Survival</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Joo Hun</creatorcontrib><creatorcontrib>Choi, Ho</creatorcontrib><creatorcontrib>Kim, Young Bae</creatorcontrib><creatorcontrib>Kim, Young Sun</creatorcontrib><creatorcontrib>Sheen, Seung Soo</creatorcontrib><creatorcontrib>Choi, Jin-Hyuk</creatorcontrib><creatorcontrib>Lee, Hye Lim</creatorcontrib><creatorcontrib>Lee, Keu Sung</creatorcontrib><creatorcontrib>Chung, Woo Young</creatorcontrib><creatorcontrib>Lee, Sungsoo</creatorcontrib><creatorcontrib>Park, Kyung Joo</creatorcontrib><creatorcontrib>Hwang, Sung Chul</creatorcontrib><creatorcontrib>Lee, Kyi Beum</creatorcontrib><creatorcontrib>Park, Kwang Joo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Joo Hun</au><au>Choi, Ho</au><au>Kim, Young Bae</au><au>Kim, Young Sun</au><au>Sheen, Seung Soo</au><au>Choi, Jin-Hyuk</au><au>Lee, Hye Lim</au><au>Lee, Keu Sung</au><au>Chung, Woo Young</au><au>Lee, Sungsoo</au><au>Park, Kyung Joo</au><au>Hwang, Sung Chul</au><au>Lee, Kyi Beum</au><au>Park, Kwang Joo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>66</volume><issue>3</issue><spage>359</spage><epage>364</epage><pages>359-364</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><coden>LUCAE5</coden><abstract>Abstract Purpose We evaluated the clinical significance of angiopoietins and vascular endothelial growth factor (VEGF) in patients with resected early stage lung cancer. Patients and methods The study enrolled 101 patients with completely resected non-small cell lung cancer (NSCLC) of stage I or II, along with 70 healthy volunteers. Serum concentrations of angiopoietin-1, angiopoietin-2, and VEGF were measured with an ELISA. Immunohistochemical expression of angiopoietin-1 was compared with the microvessel density on the lung cancer tissues. Results The patients had lower serum angiopoietin-1 (32.1 ± 9.9 ng/mL vs. 39.0 ± 10.8 ng/mL, p < 0.001), higher angiopoietin-2 (1949.2 ± 1099.4 pg/mL vs. 1498.6 ± 650.0 pg/mL, p < 0.01), and higher VEGF (565.1 ± 406.3 pg/mL vs. 404.6 ± 254.8 pg/mL, p < 0.01) levels than the controls. The angiopoietin-2 level was higher in stage II than in stage I patients ( p < 0.05). The levels of angiopoietin-1 ( r = 0.28) and angiopoietin-2 ( r = 0.36) each correlated with the VEGF level. Patients with a higher level of angiopoietin-1 (≥31.2 ng/mL) had better disease-specific and relapse-free survival than those with a lower angiopoietin-1 level (<31.2 ng/mL). Angiopoietin-1 expression negatively correlated with the microvessel density. Conclusion Serum angiopoietin-1 is a potential marker for predicting postoperative survival and recurrence in patients with early stage NSCLC.</abstract><cop>Oxford</cop><pub>Elsevier Ireland Ltd</pub><pmid>19339077</pmid><doi>10.1016/j.lungcan.2009.03.002</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Angiopoietin-1 Angiopoietin-1 - biosynthesis Angiopoietin-1 - blood Angiopoietin-1 - genetics Angiopoietin-2 - blood Biological and medical sciences Biomarkers, Tumor - blood Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - physiopathology Disease-Free Survival Early stage Enzyme-Linked Immunosorbent Assay Female Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Lung - metabolism Lung - pathology Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - pathology Lung Neoplasms - physiopathology Male Medical sciences Microvessels - pathology Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Non-small cell lung cancer Pneumology Prognosis Pulmonary/Respiratory Survival Tumors Tumors of the respiratory system and mediastinum Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood |
| title | Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer |
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