Identification and expression analysis of the aldo–ketoreductase1-B10 gene in primary malignant liver tumours

Background & Aims The aim of our study was to search for highly up-regulated genes in primary malignant liver tumours and to analyse their expression at the mRNA- and protein level. Methods Using a random-based gene fishing approach (representational difference analysis coupled to array hybridis...

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Veröffentlicht in:	Journal of hepatology 2010-02, Vol.52 (2), p.220-227
Hauptverfasser:	Heringlake, Stefan, Hofdmann, Michael, Fiebeler, Anette, Manns, Michael P, Schmiegel, Wolff, Tannapfel, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - genetics Aldehyde Reductase - metabolism Aldo–ketoreductase Base Sequence Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Case-Control Studies Cell Differentiation Cell Proliferation Cholangiocarcinoma - enzymology Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology DNA Primers - genetics Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Profiling Hepatocellular carcinoma Humans Immunohistochemistry Liver Cirrhosis - enzymology Liver Cirrhosis - genetics Liver Neoplasms - enzymology Liver Neoplasms - genetics Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Neoplasm Staging Oligonucleotide Array Sequence Analysis Representational difference analysis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Tumors
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