Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria

The p14(ARF) tumor suppressor is frequently targeted for inactivation in many human cancers and in individuals predisposed to cutaneous melanoma. The functions of p14(ARF) are closely linked with its subcellular distribution. Nucleolar p14(ARF) dampens ribosome biosynthesis and nucleoplasmic forms o...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2010-02, Vol.9 (4), p.829-839
Hauptverfasser:	Irvine, Mal, Philipsz, Suzanah, Frausto, Monika, Mijatov, Branka, Gallagher, Stuart J, Fung, Carina, Becker, Therese M, Kefford, Richard F, Rizos, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis bcl-X Protein - metabolism Cell Line, Tumor Humans Hydrophobic and Hydrophilic Interactions Mice Mitochondria - metabolism Mitochondrial Proteins - metabolism Molecular Sequence Data Protein Structure, Tertiary Sequence Alignment Signal Transduction Tumor Suppressor Protein p14ARF - metabolism Tumor Suppressor Protein p53 - metabolism
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