Cyclosporin A-sensitive decrease in the transmembrane potential across the inner membrane of liver mitochondria induced by low concentrations of fatty acids and Ca2

At low Ca2+ concentrations the pore of the inner mitochondrial membrane can open in substates with lower permeability (Hunter, D. R., and Haworth, R. A. (1979) Arch. Biochem. Biophys., 195, 468-477). Recently, we showed that Ca2+ loading of mitochondria augments the cyclosporin A-dependent decrease...

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Veröffentlicht in:	Biochemistry (Moscow) 2003-04, Vol.68 (4), p.391-398
Hauptverfasser:	Bodrova, M E, Brailovskaya, I V, Efron, G I, Starkov, A A, Mokhova, E N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Animals ATP Binding sites Calcium - pharmacology Cations Cyclosporine - pharmacology Dose-Response Relationship, Drug Fatty acids Fatty Acids - pharmacology Glutamic Acid - chemistry Glutamic Acid - metabolism Intracellular Membranes - drug effects Intracellular Membranes - physiology Kinetics Malates - chemistry Malates - metabolism Membrane Potentials - drug effects Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - physiology Mitochondrial ADP, ATP Translocases - metabolism Myristic Acid - pharmacology Nigericin - pharmacology Nitriles - pharmacology Permeability Rats Rotenone Substrate Specificity Uncoupling Agents - pharmacology
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