Structural organization of the human insulin receptor ectodomain

To provide an experimental system amenable to a detailed biochemical and structural investigation of the extracellular (ligand binding) domain of the insulin receptor, we developed a mammalian heterologous cell expression system from which tens of milligrams of the soluble secreted ectodomain (the I...

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Veröffentlicht in:	The Journal of biological chemistry 1992-11, Vol.267 (32), p.23393-23402
Hauptverfasser:	Schaefer, E M, Erickson, H P, Federwisch, M, Wollmer, A, Ellis, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Cell Adhesion Molecules, Neuronal - chemistry CHO Cells Circular Dichroism Cricetinae ectodomains Extracellular Matrix Proteins - chemistry Growth Hormone - chemistry Humans insulin man Mathematics membrane proteins Microscopy, Electron Models, Structural Models, Theoretical Molecular Sequence Data Protein Conformation protein-tyrosine kinase Receptor, Insulin - chemistry Receptor, Insulin - isolation & purification Receptor, Insulin - ultrastructure receptors Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Recombinant Proteins - ultrastructure Repetitive Sequences, Nucleic Acid Sequence Homology, Amino Acid Spectrometry, Fluorescence structure Tenascin Transfection
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