Venom of the Scorpion Vejovis spinigerus

The chemical composition of lyophilized venom from Vejovis spinigerus is reported. At least 13 distinct bands were obtained on disc electrophoresis; on Sephadex G-50, four major peaks were found. The lethal activity was associated with the second peak. The intravenous lethal dose, median (lethal for 50 percent of inoculated group), of the crude venom was 4.87 milligrams per kilogram of body weight. Neither the crude venom nor its fractions had a deleterious effect on neuromuscular transmission, reflex discharge, or antidromic inhibition. Crude venom evoked simultaneous changes in systemic arterial, venous, and cisternal pressures.