Thyroid hormones induce activation of rat hepatic stellate cells through increased expression of p75 neurotrophin receptor and direct activation of Rho

We have previously shown that hyperthyroidism is detrimental for liver fibrosis and in this study we have investigated the mechanisms regulating triiodothyronine (T3) and L-thyroxine (T4) activation of hepatic stellate cells (HSC). Expression of α-smooth muscle actin (αSMA) and p75 neurotrophin rece...

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Veröffentlicht in:	Laboratory investigation 2010-05, Vol.90 (5), p.674-684
Hauptverfasser:	Zvibel, Isabel, Atias, Dikla, Phillips, Adam, Halpern, Zamir, Oren, Ran
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/776/1180 631/80/86/2341 692/698/2741/288/2140 692/699/1503/1607/1605 Actins - genetics Actins - metabolism Animals Biological and medical sciences Biotechnology Blotting, Western Cell Transdifferentiation - drug effects Cells, Cultured Enzyme Activation - drug effects Enzyme-Linked Immunosorbent Assay Female Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen hepatic stellate cells Hepatic Stellate Cells - cytology Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Integrin alphaVbeta3 - genetics Integrin alphaVbeta3 - metabolism Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Liver Cirrhosis - metabolism Liver Cirrhosis - pathology liver fibrosis Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Muscle, Smooth - chemistry Other diseases. Semiology p75 neurotrophin receptor Pathology Rats Rats, Wistar Receptor, Nerve Growth Factor - genetics Receptor, Nerve Growth Factor - metabolism research-article Reverse Transcriptase Polymerase Chain Reaction Rho activation rho-Associated Kinases - metabolism Thyroid Hormone Receptors alpha - genetics Thyroid Hormone Receptors alpha - metabolism thyroid hormones Thyroid Hormones - metabolism Thyroid Hormones - pharmacology Thyroxine - metabolism Thyroxine - pharmacology Triiodothyronine - metabolism Triiodothyronine - pharmacology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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