The endothelial cell in health and disease: its function, dysfunction, measurement and therapy
Endothelial cells have numerous endocrine functions and contribute to a variety of processes, including penile erection and vasodilation. Endothelial dysfunction is associated with cardiovascular risk factors and has been implicated in the pathogenesis of atherosclerosis and ED. This study reviews e...
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| Veröffentlicht in: | International journal of impotence research 2010-03, Vol.22 (2), p.77-90 |
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| container_title | International journal of impotence research |
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| creator | Schwartz, B G Economides, C Mayeda, G S Burstein, S Kloner, R A |
| description | Endothelial cells have numerous endocrine functions and contribute to a variety of processes, including penile erection and vasodilation. Endothelial dysfunction is associated with cardiovascular risk factors and has been implicated in the pathogenesis of atherosclerosis and ED. This study reviews endothelial function, in addition to endothelial dysfunction and its role in atherosclerosis and ED. Measurement of endothelial function is reviewed, including catheter-based methods, venous occlusion plethysmography, high-frequency ultrasound, peripheral arterial tonometry, digital pulse amplitude tonometry, digital thermal monitoring, the
L
-arginine test and measurement of compounds released by endothelial cells. Therapy and medications that improve endothelial function are reviewed. As the scientific community learns more about the importance of the endothelium, it is increasingly important for the clinician to understand endothelial function, dysfunction, measurement of endothelial function and therapies that affect this remarkable cell type. |
| doi_str_mv | 10.1038/ijir.2009.59 |
| format | Article |
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L
-arginine test and measurement of compounds released by endothelial cells. Therapy and medications that improve endothelial function are reviewed. As the scientific community learns more about the importance of the endothelium, it is increasingly important for the clinician to understand endothelial function, dysfunction, measurement of endothelial function and therapies that affect this remarkable cell type.</description><identifier>ISSN: 0955-9930</identifier><identifier>EISSN: 1476-5489</identifier><identifier>DOI: 10.1038/ijir.2009.59</identifier><identifier>PMID: 20032988</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Arginine ; Atherosclerosis ; Atherosclerosis - drug therapy ; Atherosclerosis - etiology ; Atherosclerosis - physiopathology ; Biological and medical sciences ; Care and treatment ; Catheterization ; Constriction ; Coronary Vessels ; Development and progression ; Diagnosis ; Endothelial Cells - cytology ; Endothelial Cells - drug effects ; Endothelial Cells - physiology ; Endothelium ; Enzyme Inhibitors - therapeutic use ; Erectile Dysfunction - drug therapy ; Erectile Dysfunction - etiology ; Erectile Dysfunction - physiopathology ; Gynecology. Andrology. Obstetrics ; Humans ; Impotence ; Male ; Manometry ; Measurement ; Medical sciences ; Medicine ; Medicine & Public Health ; Nitric oxide ; Nitric Oxide - pharmacology ; Penile Erection - drug effects ; Penile Erection - physiology ; Phosphodiesterase 5 Inhibitors ; Physiological aspects ; Plethysmography ; Reproductive Medicine ; review ; Risk factors ; rology ; Urology ; Vasodilation - drug effects ; Vasodilation - physiology ; Veins</subject><ispartof>International journal of impotence research, 2010-03, Vol.22 (2), p.77-90</ispartof><rights>Springer Nature Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2010</rights><rights>Nature Publishing Group 2010.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-106b600e1d11d14b484aa0457f674fca47884c8cec9e4032d1cca2f92bd5cb233</citedby><cites>FETCH-LOGICAL-c536t-106b600e1d11d14b484aa0457f674fca47884c8cec9e4032d1cca2f92bd5cb233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijir.2009.59$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijir.2009.59$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22491417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20032988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwartz, B G</creatorcontrib><creatorcontrib>Economides, C</creatorcontrib><creatorcontrib>Mayeda, G S</creatorcontrib><creatorcontrib>Burstein, S</creatorcontrib><creatorcontrib>Kloner, R A</creatorcontrib><title>The endothelial cell in health and disease: its function, dysfunction, measurement and therapy</title><title>International journal of impotence research</title><addtitle>Int J Impot Res</addtitle><addtitle>Int J Impot Res</addtitle><description>Endothelial cells have numerous endocrine functions and contribute to a variety of processes, including penile erection and vasodilation. Endothelial dysfunction is associated with cardiovascular risk factors and has been implicated in the pathogenesis of atherosclerosis and ED. This study reviews endothelial function, in addition to endothelial dysfunction and its role in atherosclerosis and ED. Measurement of endothelial function is reviewed, including catheter-based methods, venous occlusion plethysmography, high-frequency ultrasound, peripheral arterial tonometry, digital pulse amplitude tonometry, digital thermal monitoring, the
L
-arginine test and measurement of compounds released by endothelial cells. Therapy and medications that improve endothelial function are reviewed. As the scientific community learns more about the importance of the endothelium, it is increasingly important for the clinician to understand endothelial function, dysfunction, measurement of endothelial function and therapies that affect this remarkable cell type.</description><subject>Arginine</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - drug therapy</subject><subject>Atherosclerosis - etiology</subject><subject>Atherosclerosis - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Care and treatment</subject><subject>Catheterization</subject><subject>Constriction</subject><subject>Coronary Vessels</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - physiology</subject><subject>Endothelium</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Erectile Dysfunction - drug therapy</subject><subject>Erectile Dysfunction - etiology</subject><subject>Erectile Dysfunction - physiopathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Impotence</subject><subject>Male</subject><subject>Manometry</subject><subject>Measurement</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - pharmacology</subject><subject>Penile Erection - drug effects</subject><subject>Penile Erection - physiology</subject><subject>Phosphodiesterase 5 Inhibitors</subject><subject>Physiological aspects</subject><subject>Plethysmography</subject><subject>Reproductive Medicine</subject><subject>review</subject><subject>Risk factors</subject><subject>rology</subject><subject>Urology</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><subject>Veins</subject><issn>0955-9930</issn><issn>1476-5489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp10ktv1DAQAGALgehSuHFGFhXl0ix-Jja3qqKAVIlLuWI5zqTrVeIsdnLYf49Dli5FVIkUOflmxp4MQq8pWVPC1Qe_9XHNCNFrqZ-gFRVVWUih9FO0IlrKQmtOTtCLlLYkI0LL5-gkc860Uiv043YDGEIzjBvovO2wg67DPuAN2G7cYBsa3PgENsFH7MeE2ym40Q_hAjf7dFz0WUwRegjj75icLtrd_iV61touwavD8xR9v_50e_WluPn2-evV5U3hJC_HgpKyLgkB2tB8i1ooYS0RsmrLSrTOikop4ZQDp0HkrTfUOctazepGuppxforeL3l3cfg5QRpN79N8FBtgmJKpOKeyooJmefaP3A5TDHlzhpVCcs6JFFm9fVRRpRUTFTmmurMdGB_aYYzWzYXNJWOMMElkldX6PypfDfTeDQFan98_CDj_K2D5D2noprnR6SG8WKCLQ0oRWrOLvrdxbygx82yYeTbMPBtG6szfHM401T009_jPMGTw7gBscrZrow3Op6NjQucOznWLxaX8KdxBPDbnkcJ48cGOeUbuE85oNpn8AsYo2GE</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Schwartz, B G</creator><creator>Economides, C</creator><creator>Mayeda, G S</creator><creator>Burstein, S</creator><creator>Kloner, R A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>The endothelial cell in health and disease: its function, dysfunction, measurement and therapy</title><author>Schwartz, B G ; Economides, C ; Mayeda, G S ; Burstein, S ; Kloner, R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-106b600e1d11d14b484aa0457f674fca47884c8cec9e4032d1cca2f92bd5cb233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Arginine</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - drug therapy</topic><topic>Atherosclerosis - etiology</topic><topic>Atherosclerosis - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Care and treatment</topic><topic>Catheterization</topic><topic>Constriction</topic><topic>Coronary Vessels</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - physiology</topic><topic>Endothelium</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Erectile Dysfunction - drug therapy</topic><topic>Erectile Dysfunction - etiology</topic><topic>Erectile Dysfunction - physiopathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Impotence</topic><topic>Male</topic><topic>Manometry</topic><topic>Measurement</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - pharmacology</topic><topic>Penile Erection - drug effects</topic><topic>Penile Erection - physiology</topic><topic>Phosphodiesterase 5 Inhibitors</topic><topic>Physiological aspects</topic><topic>Plethysmography</topic><topic>Reproductive Medicine</topic><topic>review</topic><topic>Risk factors</topic><topic>rology</topic><topic>Urology</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwartz, B G</creatorcontrib><creatorcontrib>Economides, C</creatorcontrib><creatorcontrib>Mayeda, G S</creatorcontrib><creatorcontrib>Burstein, S</creatorcontrib><creatorcontrib>Kloner, R A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of impotence research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwartz, B G</au><au>Economides, C</au><au>Mayeda, G S</au><au>Burstein, S</au><au>Kloner, R A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The endothelial cell in health and disease: its function, dysfunction, measurement and therapy</atitle><jtitle>International journal of impotence research</jtitle><stitle>Int J Impot Res</stitle><addtitle>Int J Impot Res</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>22</volume><issue>2</issue><spage>77</spage><epage>90</epage><pages>77-90</pages><issn>0955-9930</issn><eissn>1476-5489</eissn><abstract>Endothelial cells have numerous endocrine functions and contribute to a variety of processes, including penile erection and vasodilation. Endothelial dysfunction is associated with cardiovascular risk factors and has been implicated in the pathogenesis of atherosclerosis and ED. This study reviews endothelial function, in addition to endothelial dysfunction and its role in atherosclerosis and ED. Measurement of endothelial function is reviewed, including catheter-based methods, venous occlusion plethysmography, high-frequency ultrasound, peripheral arterial tonometry, digital pulse amplitude tonometry, digital thermal monitoring, the
L
-arginine test and measurement of compounds released by endothelial cells. Therapy and medications that improve endothelial function are reviewed. As the scientific community learns more about the importance of the endothelium, it is increasingly important for the clinician to understand endothelial function, dysfunction, measurement of endothelial function and therapies that affect this remarkable cell type.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20032988</pmid><doi>10.1038/ijir.2009.59</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of impotence research, 2010-03, Vol.22 (2), p.77-90 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Arginine Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - etiology Atherosclerosis - physiopathology Biological and medical sciences Care and treatment Catheterization Constriction Coronary Vessels Development and progression Diagnosis Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - physiology Endothelium Enzyme Inhibitors - therapeutic use Erectile Dysfunction - drug therapy Erectile Dysfunction - etiology Erectile Dysfunction - physiopathology Gynecology. Andrology. Obstetrics Humans Impotence Male Manometry Measurement Medical sciences Medicine Medicine & Public Health Nitric oxide Nitric Oxide - pharmacology Penile Erection - drug effects Penile Erection - physiology Phosphodiesterase 5 Inhibitors Physiological aspects Plethysmography Reproductive Medicine review Risk factors rology Urology Vasodilation - drug effects Vasodilation - physiology Veins |
| title | The endothelial cell in health and disease: its function, dysfunction, measurement and therapy |
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