Nedd4-Interacting Protein 2, a Short Half-life Membrane Protein Degraded in Lysosomes, Negatively Controls Down-Regulation of Connexin43

Nedd4-interacting protein 2 (NDFIP2) has three transmembrane domains and interacts with multiple Nedd4 family ubiquitin ligases through polyprolinetyrosine (PY) motifs located in its N-terminal cytoplasmic domain. It has been postulated that NDFIP2 acts as an adaptor for the ubiquitylation of substr...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2010/06/01, Vol.33(6), pp.951-957
Hauptverfasser:	Ohzono, Chiho, Etoh, Sachise, Matsumoto, Masaki, Nakayama, Keiichi I, Hirota, Yuko, Tanaka, Yoshitaka, Fujita, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Cercopithecus aethiops Connexin 43 - metabolism COS Cells DNA Repair Enzymes Down-Regulation - drug effects endocytosis Endosomal Sorting Complexes Required for Transport - metabolism gap junction Gap Junctions - physiology Golgi Apparatus - metabolism HeLa Cells Humans lysosome Lysosomes - metabolism Nedd4 Ubiquitin Protein Ligases Peptides - metabolism proteolysis Rats RNA, Small Interfering trans-Golgi Network - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination ubiquitylation
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