Intralobular Differences in Antioxidant Enzyme Expression and Activity Reflect the Pattern of Maternal Arterial Bloodflow Within the Human Placenta

The aim was to determine whether the activities and mRNA concentrations of antioxidant enzymes in human placental tissues reflect the prevailing oxygen tension or developmental maturity of the villi. Advantage was taken of contrasting gradients within lobules of the mature placenta. The central regi...

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Veröffentlicht in:	Placenta (Eastbourne) 2003-05, Vol.24 (5), p.517-523
Hauptverfasser:	Hempstock, J., Bao, Y-P., Bar-Issac, M., Segaren, N., Watson, A.L., Charnock-Jones, D.S., Jauniaux, E., Burton, G.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antioxidants - metabolism Arteries - physiology Catalase - genetics Catalase - metabolism Cells, Cultured Chorionic Villi - drug effects Chorionic Villi - enzymology DNA Primers - chemistry Dose-Response Relationship, Drug Female Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Humans Oxygen - pharmacology Placenta - blood supply Pregnancy Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Superoxide Dismutase - genetics Superoxide Dismutase - metabolism
Online-Zugang:	Volltext
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