Association of −308G/A polymorphism in the tumor necrosis factor-α gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeirão Preto region, Brazil
Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF −308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele w...
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| Veröffentlicht in: | Archives of virology 2010, Vol.155 (6), p.971-975 |
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| creator | Borges, Alessandra Abel Donadi, Eduardo Antônio Campos, Gelse Mazzoni Moreli, Marcos Lázaro de Sousa, Ricardo Luiz Moro Saggioro, Fabiano Pinto de Figueiredo, Glauciane Garcia Badra, Soraya Jabur Deghaide, Neifi Hassan Saloum Figueiredo, Luiz Tadeu Moraes |
| description | Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF −308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS. |
| doi_str_mv | 10.1007/s00705-010-0655-7 |
| format | Article |
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The polymorphic TNF2 allele (TNF −308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-010-0655-7</identifier><identifier>PMID: 20372945</identifier><language>eng</language><publisher>Vienna: Vienna : Springer Vienna</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Brazil ; Brief Report ; Female ; Fundamental and applied biological sciences. 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The polymorphic TNF2 allele (TNF −308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brazil</subject><subject>Brief Report</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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The polymorphic TNF2 allele (TNF −308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS.</abstract><cop>Vienna</cop><pub>Vienna : Springer Vienna</pub><pmid>20372945</pmid><doi>10.1007/s00705-010-0655-7</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Biomedical and Life Sciences Biomedicine Brazil Brief Report Female Fundamental and applied biological sciences. Psychology genes Genetic Predisposition to Disease Hantavirus Infections - genetics Hantavirus Infections - virology Hantavirus Pulmonary Syndrome - genetics Hantavirus Pulmonary Syndrome - virology Heart Diseases - genetics Heart Diseases - virology Humans immune response Infectious Diseases Male Medical Microbiology Microbiology Middle Aged Miscellaneous necrosis patients Polymorphism, Genetic Promoter Regions, Genetic - genetics risk factors Syndrome tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - genetics Virology Young Adult |
| title | Association of −308G/A polymorphism in the tumor necrosis factor-α gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeirão Preto region, Brazil |
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