A New Way: Alleviating Postembolization Syndrome Following Transcatheter Arterial Chemoembolization
Background: Currently, most therapies of postembolization syndrome following transcatheter arterial chemoembolization (TACE) aim directly at a single symptom, thus leading to limitations. Objectives: To seek for a systematic approach to prevent and treat the syndrome, we carried out this study to ob...
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| Veröffentlicht in: | The journal of alternative and complementary medicine (New York, N.Y.) N.Y.), 2009-02, Vol.15 (2), p.175-181 |
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| container_title | The journal of alternative and complementary medicine (New York, N.Y.) |
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| creator | Yinglu, Feng Changquan, Ling Xiaofeng, Zhai Bai, Li Dezeng, Zhu Zhe, Chen |
| description | Background:
Currently, most therapies of postembolization syndrome following transcatheter arterial chemoembolization (TACE) aim directly at a single symptom, thus leading to limitations.
Objectives:
To seek for a systematic approach to prevent and treat the syndrome, we carried out this study to observe the effect of ginsenosides (GS) and dexamethasone (Dex) in alleviating the postembolization syndrome following TACE.
Methods:
In the randomized, double-blinded and controlled trial, 120 patients with primary liver cancer were divided into 4 groups, with 30 patients in each group. The changes of clinical symptoms and laboratory tests before TACE and on 3 and 7 days after TACE were observed.
Results:
The results indicated that Dex combined with GS not only markedly decreased the occurrence ratio and duration of such symptoms as nausea, vomiting, and fever, but also significantly reduced levels of total bilirubin, glutamic oxaloacetic transaminase, and glutamic-pyruvic transaminase (AST) and improved the Child-Pugh stage of liver function as compared with single use of GS or Dex.
Conclusions:
In conclusion, although single use of Dex or GS may improve some indices of adverse effects after TACE, the combination of Dex and GS can systematically prevent and treat the postembolization syndrome following TACE. |
| doi_str_mv | 10.1089/acm.2008.0093 |
| format | Article |
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Currently, most therapies of postembolization syndrome following transcatheter arterial chemoembolization (TACE) aim directly at a single symptom, thus leading to limitations.
Objectives:
To seek for a systematic approach to prevent and treat the syndrome, we carried out this study to observe the effect of ginsenosides (GS) and dexamethasone (Dex) in alleviating the postembolization syndrome following TACE.
Methods:
In the randomized, double-blinded and controlled trial, 120 patients with primary liver cancer were divided into 4 groups, with 30 patients in each group. The changes of clinical symptoms and laboratory tests before TACE and on 3 and 7 days after TACE were observed.
Results:
The results indicated that Dex combined with GS not only markedly decreased the occurrence ratio and duration of such symptoms as nausea, vomiting, and fever, but also significantly reduced levels of total bilirubin, glutamic oxaloacetic transaminase, and glutamic-pyruvic transaminase (AST) and improved the Child-Pugh stage of liver function as compared with single use of GS or Dex.
Conclusions:
In conclusion, although single use of Dex or GS may improve some indices of adverse effects after TACE, the combination of Dex and GS can systematically prevent and treat the postembolization syndrome following TACE.</description><identifier>ISSN: 1075-5535</identifier><identifier>EISSN: 1557-7708</identifier><identifier>DOI: 10.1089/acm.2008.0093</identifier><identifier>PMID: 19216654</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adult ; Aged ; Alanine Transaminase - blood ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Aspartate Aminotransferases - blood ; Bilirubin - blood ; Chemoembolization, Therapeutic - adverse effects ; Chemoembolization, Therapeutic - methods ; Combined Modality Therapy ; Dexamethasone - therapeutic use ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Fever - drug therapy ; Fever - etiology ; Ginsenosides - therapeutic use ; Humans ; Liver Neoplasms - blood ; Liver Neoplasms - complications ; Liver Neoplasms - drug therapy ; Male ; Middle Aged ; Nausea - drug therapy ; Nausea - etiology ; ORIGINAL PAPERS ; Panax - chemistry ; Phytotherapy ; Plant Extracts - therapeutic use ; Vomiting - drug therapy ; Vomiting - etiology</subject><ispartof>The journal of alternative and complementary medicine (New York, N.Y.), 2009-02, Vol.15 (2), p.175-181</ispartof><rights>2009 Mary Ann Liebert, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-9b483df193efd632865819e9a369c8b78d1963bbf2d930ada2560e04f342575f3</citedby><cites>FETCH-LOGICAL-c394t-9b483df193efd632865819e9a369c8b78d1963bbf2d930ada2560e04f342575f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19216654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yinglu, Feng</creatorcontrib><creatorcontrib>Changquan, Ling</creatorcontrib><creatorcontrib>Xiaofeng, Zhai</creatorcontrib><creatorcontrib>Bai, Li</creatorcontrib><creatorcontrib>Dezeng, Zhu</creatorcontrib><creatorcontrib>Zhe, Chen</creatorcontrib><title>A New Way: Alleviating Postembolization Syndrome Following Transcatheter Arterial Chemoembolization</title><title>The journal of alternative and complementary medicine (New York, N.Y.)</title><addtitle>J Altern Complement Med</addtitle><description>Background:
Currently, most therapies of postembolization syndrome following transcatheter arterial chemoembolization (TACE) aim directly at a single symptom, thus leading to limitations.
Objectives:
To seek for a systematic approach to prevent and treat the syndrome, we carried out this study to observe the effect of ginsenosides (GS) and dexamethasone (Dex) in alleviating the postembolization syndrome following TACE.
Methods:
In the randomized, double-blinded and controlled trial, 120 patients with primary liver cancer were divided into 4 groups, with 30 patients in each group. The changes of clinical symptoms and laboratory tests before TACE and on 3 and 7 days after TACE were observed.
Results:
The results indicated that Dex combined with GS not only markedly decreased the occurrence ratio and duration of such symptoms as nausea, vomiting, and fever, but also significantly reduced levels of total bilirubin, glutamic oxaloacetic transaminase, and glutamic-pyruvic transaminase (AST) and improved the Child-Pugh stage of liver function as compared with single use of GS or Dex.
Conclusions:
In conclusion, although single use of Dex or GS may improve some indices of adverse effects after TACE, the combination of Dex and GS can systematically prevent and treat the postembolization syndrome following TACE.</description><subject>Adult</subject><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Bilirubin - blood</subject><subject>Chemoembolization, Therapeutic - adverse effects</subject><subject>Chemoembolization, Therapeutic - methods</subject><subject>Combined Modality Therapy</subject><subject>Dexamethasone - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fever - drug therapy</subject><subject>Fever - etiology</subject><subject>Ginsenosides - therapeutic use</subject><subject>Humans</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nausea - drug therapy</subject><subject>Nausea - etiology</subject><subject>ORIGINAL PAPERS</subject><subject>Panax - chemistry</subject><subject>Phytotherapy</subject><subject>Plant Extracts - therapeutic use</subject><subject>Vomiting - drug therapy</subject><subject>Vomiting - etiology</subject><issn>1075-5535</issn><issn>1557-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLw0AURgdRbH0s3Up2LiR1JpN5uSvFqlBUsOJymCQ3NjLJ1JnUUn-9CS0-NvdePs79FgehM4JHBEt1ZfJ6lGAsRxgruoeGhDERC4HlfndjwWLGKBugoxDeMcZpqpJDNCAqIZyzdIjycfQA6-jVbK6jsbXwWZm2at6iJxdaqDNnq68ucE30vGkK72qIps5at-6ZuTdNyE27gBZ8NPbdrIyNJguo3d_fE3RQGhvgdLeP0cv0Zj65i2ePt_eT8SzOqUrbWGWppEVJFIWy4DSRnEmiQBnKVS4zIQuiOM2yMikUxaYwCeMYcFrSNGGClfQYXWx7l959rCC0uq5CDtaaBtwqaEEpoVwK3JHxlsy9C8FDqZe-qo3faIJ1r1V3WnWvVfdaO_5817zKaih-6Z3HDrjcAn1smsZWkIFvf8D_dd_d74Nl</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Yinglu, Feng</creator><creator>Changquan, Ling</creator><creator>Xiaofeng, Zhai</creator><creator>Bai, Li</creator><creator>Dezeng, Zhu</creator><creator>Zhe, Chen</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>A New Way: Alleviating Postembolization Syndrome Following Transcatheter Arterial Chemoembolization</title><author>Yinglu, Feng ; Changquan, Ling ; Xiaofeng, Zhai ; Bai, Li ; Dezeng, Zhu ; Zhe, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-9b483df193efd632865819e9a369c8b78d1963bbf2d930ada2560e04f342575f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alanine Transaminase - blood</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Bilirubin - blood</topic><topic>Chemoembolization, Therapeutic - adverse effects</topic><topic>Chemoembolization, Therapeutic - methods</topic><topic>Combined Modality Therapy</topic><topic>Dexamethasone - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Fever - drug therapy</topic><topic>Fever - etiology</topic><topic>Ginsenosides - therapeutic use</topic><topic>Humans</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nausea - drug therapy</topic><topic>Nausea - etiology</topic><topic>ORIGINAL PAPERS</topic><topic>Panax - chemistry</topic><topic>Phytotherapy</topic><topic>Plant Extracts - therapeutic use</topic><topic>Vomiting - drug therapy</topic><topic>Vomiting - etiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Yinglu, Feng</creatorcontrib><creatorcontrib>Changquan, Ling</creatorcontrib><creatorcontrib>Xiaofeng, Zhai</creatorcontrib><creatorcontrib>Bai, Li</creatorcontrib><creatorcontrib>Dezeng, Zhu</creatorcontrib><creatorcontrib>Zhe, Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of alternative and complementary medicine (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yinglu, Feng</au><au>Changquan, Ling</au><au>Xiaofeng, Zhai</au><au>Bai, Li</au><au>Dezeng, Zhu</au><au>Zhe, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Way: Alleviating Postembolization Syndrome Following Transcatheter Arterial Chemoembolization</atitle><jtitle>The journal of alternative and complementary medicine (New York, N.Y.)</jtitle><addtitle>J Altern Complement Med</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>15</volume><issue>2</issue><spage>175</spage><epage>181</epage><pages>175-181</pages><issn>1075-5535</issn><eissn>1557-7708</eissn><abstract>Background:
Currently, most therapies of postembolization syndrome following transcatheter arterial chemoembolization (TACE) aim directly at a single symptom, thus leading to limitations.
Objectives:
To seek for a systematic approach to prevent and treat the syndrome, we carried out this study to observe the effect of ginsenosides (GS) and dexamethasone (Dex) in alleviating the postembolization syndrome following TACE.
Methods:
In the randomized, double-blinded and controlled trial, 120 patients with primary liver cancer were divided into 4 groups, with 30 patients in each group. The changes of clinical symptoms and laboratory tests before TACE and on 3 and 7 days after TACE were observed.
Results:
The results indicated that Dex combined with GS not only markedly decreased the occurrence ratio and duration of such symptoms as nausea, vomiting, and fever, but also significantly reduced levels of total bilirubin, glutamic oxaloacetic transaminase, and glutamic-pyruvic transaminase (AST) and improved the Child-Pugh stage of liver function as compared with single use of GS or Dex.
Conclusions:
In conclusion, although single use of Dex or GS may improve some indices of adverse effects after TACE, the combination of Dex and GS can systematically prevent and treat the postembolization syndrome following TACE.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>19216654</pmid><doi>10.1089/acm.2008.0093</doi><tpages>7</tpages></addata></record> |
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| ispartof | The journal of alternative and complementary medicine (New York, N.Y.), 2009-02, Vol.15 (2), p.175-181 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Alanine Transaminase - blood Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Aspartate Aminotransferases - blood Bilirubin - blood Chemoembolization, Therapeutic - adverse effects Chemoembolization, Therapeutic - methods Combined Modality Therapy Dexamethasone - therapeutic use Double-Blind Method Drug Therapy, Combination Female Fever - drug therapy Fever - etiology Ginsenosides - therapeutic use Humans Liver Neoplasms - blood Liver Neoplasms - complications Liver Neoplasms - drug therapy Male Middle Aged Nausea - drug therapy Nausea - etiology ORIGINAL PAPERS Panax - chemistry Phytotherapy Plant Extracts - therapeutic use Vomiting - drug therapy Vomiting - etiology |
| title | A New Way: Alleviating Postembolization Syndrome Following Transcatheter Arterial Chemoembolization |
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