Susceptibility loci reported in genome‐wide association studies are associated with Crohn’s disease in Canadian children
Aliment Pharmacol Ther 31, 1186–1191 Summary Background Recent genome‐wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn’s disease (CD). Aims To investigate whether reported genes/loci were also associated with CD i...
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| creator | AMRE, D. K. MACK, D. R. MORGAN, K. ISRAEL, D. DESLANDRES, C. SEIDMAN, E. G. LAMBRETTE, P. COSTEA, I. KRUPOVES, A. FEGURY, H. DONG, J. GRIMARD, G. LEVY, E. |
| description | Aliment Pharmacol Ther 31, 1186–1191
Summary
Background Recent genome‐wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn’s disease (CD).
Aims To investigate whether reported genes/loci were also associated with CD in Canadian children.
Design and Methods A case‐control design was implemented at three paediatric gastroenterology clinics in Canada. Children ≤18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome‐wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined.
Results A total of 406 cases and 415 controls were studied. The mean (±s.d.) age of the cases was 12.3 (±3.2) years. Most cases were male (56.6%), had ileo‐colonic disease (L3 ± L4, 52.0%) and inflammatory behaviour (B1 ± p, 86.9%) at diagnosis. Allelic association analysis (two‐tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement.
Conclusion The identified susceptibility genes/loci for adult‐onset CD also confer risk for paediatric‐onset CD. |
| doi_str_mv | 10.1111/j.1365-2036.2010.04294.x |
| format | Article |
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Summary
Background Recent genome‐wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn’s disease (CD).
Aims To investigate whether reported genes/loci were also associated with CD in Canadian children.
Design and Methods A case‐control design was implemented at three paediatric gastroenterology clinics in Canada. Children ≤18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome‐wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined.
Results A total of 406 cases and 415 controls were studied. The mean (±s.d.) age of the cases was 12.3 (±3.2) years. Most cases were male (56.6%), had ileo‐colonic disease (L3 ± L4, 52.0%) and inflammatory behaviour (B1 ± p, 86.9%) at diagnosis. Allelic association analysis (two‐tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement.
Conclusion The identified susceptibility genes/loci for adult‐onset CD also confer risk for paediatric‐onset CD.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2010.04294.x</identifier><identifier>PMID: 20222910</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Age of Onset ; Biological and medical sciences ; Canada - epidemiology ; Case-Control Studies ; Child ; Child, Preschool ; Crohn Disease - epidemiology ; Crohn Disease - genetics ; Digestive system ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic Loci - genetics ; Genetic Predisposition to Disease - epidemiology ; Genome ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Medical sciences ; Other diseases. Semiology ; Pharmacology. Drug treatments ; Polymorphism, Single Nucleotide ; Risk Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Alimentary pharmacology & therapeutics, 2010-06, Vol.31 (11), p.1186-1191</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4484-bd65573280ce45e141fea09a0123b520b34c9e52c56afd1c645fb8564880edf13</citedby><cites>FETCH-LOGICAL-c4484-bd65573280ce45e141fea09a0123b520b34c9e52c56afd1c645fb8564880edf13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2010.04294.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2010.04294.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22688364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20222910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AMRE, D. K.</creatorcontrib><creatorcontrib>MACK, D. R.</creatorcontrib><creatorcontrib>MORGAN, K.</creatorcontrib><creatorcontrib>ISRAEL, D.</creatorcontrib><creatorcontrib>DESLANDRES, C.</creatorcontrib><creatorcontrib>SEIDMAN, E. G.</creatorcontrib><creatorcontrib>LAMBRETTE, P.</creatorcontrib><creatorcontrib>COSTEA, I.</creatorcontrib><creatorcontrib>KRUPOVES, A.</creatorcontrib><creatorcontrib>FEGURY, H.</creatorcontrib><creatorcontrib>DONG, J.</creatorcontrib><creatorcontrib>GRIMARD, G.</creatorcontrib><creatorcontrib>LEVY, E.</creatorcontrib><title>Susceptibility loci reported in genome‐wide association studies are associated with Crohn’s disease in Canadian children</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Aliment Pharmacol Ther 31, 1186–1191
Summary
Background Recent genome‐wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn’s disease (CD).
Aims To investigate whether reported genes/loci were also associated with CD in Canadian children.
Design and Methods A case‐control design was implemented at three paediatric gastroenterology clinics in Canada. Children ≤18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome‐wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined.
Results A total of 406 cases and 415 controls were studied. The mean (±s.d.) age of the cases was 12.3 (±3.2) years. Most cases were male (56.6%), had ileo‐colonic disease (L3 ± L4, 52.0%) and inflammatory behaviour (B1 ± p, 86.9%) at diagnosis. Allelic association analysis (two‐tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement.
Conclusion The identified susceptibility genes/loci for adult‐onset CD also confer risk for paediatric‐onset CD.</description><subject>Adolescent</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Canada - epidemiology</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn Disease - genetics</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genetic Loci - genetics</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genome</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1uEzEURi0EoqHwCsgbxGqC_-NZsKgiWpAqgdSytjz2HeJo4gn2jNJILPoI3fb1-iR4SGi39cbW9fnutQ9CmJI5LevTek65khUjXM0ZKVUiWC3mNy_Q7PHiJZoRpuqKacpP0Juc14QQtSDsNTphhDFWUzJDf67G7GA7hCZ0YdjjrncBJ9j2aQCPQ8S_IPYbeLi92wUP2OZcADuEPuI8jD5AxjY91UtmF4YVXqZ-FR9u7zP2IYPNMLVa2mh9sBG7Veh8gvgWvWptl-HdcT9FP8-_XC-_VpffL74tzy4rJ4QWVeOVlAvONHEgJFBBW7CktoQy3khGGi5cDZI5qWzrqVNCto2WSmhNwLeUn6KPh77b1P8eIQ9mE8qvu85G6MdsFpwXbYuaFVIfSJf6nBO0ZpvCxqa9ocRM6s3aTIbNZNhM6s0_9eamRN8fh4zNBvxj8L_rAnw4AjY727XJRhfyE8eU1lyJwn0-cLvQwf7ZDzBnP66nE_8LfvmipQ</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>AMRE, D. K.</creator><creator>MACK, D. R.</creator><creator>MORGAN, K.</creator><creator>ISRAEL, D.</creator><creator>DESLANDRES, C.</creator><creator>SEIDMAN, E. G.</creator><creator>LAMBRETTE, P.</creator><creator>COSTEA, I.</creator><creator>KRUPOVES, A.</creator><creator>FEGURY, H.</creator><creator>DONG, J.</creator><creator>GRIMARD, G.</creator><creator>LEVY, E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201006</creationdate><title>Susceptibility loci reported in genome‐wide association studies are associated with Crohn’s disease in Canadian children</title><author>AMRE, D. K. ; MACK, D. R. ; MORGAN, K. ; ISRAEL, D. ; DESLANDRES, C. ; SEIDMAN, E. G. ; LAMBRETTE, P. ; COSTEA, I. ; KRUPOVES, A. ; FEGURY, H. ; DONG, J. ; GRIMARD, G. ; LEVY, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4484-bd65573280ce45e141fea09a0123b520b34c9e52c56afd1c645fb8564880edf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>Canada - epidemiology</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Crohn Disease - epidemiology</topic><topic>Crohn Disease - genetics</topic><topic>Digestive system</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genetic Loci - genetics</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genome</topic><topic>Genome-Wide Association Study</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AMRE, D. K.</creatorcontrib><creatorcontrib>MACK, D. R.</creatorcontrib><creatorcontrib>MORGAN, K.</creatorcontrib><creatorcontrib>ISRAEL, D.</creatorcontrib><creatorcontrib>DESLANDRES, C.</creatorcontrib><creatorcontrib>SEIDMAN, E. G.</creatorcontrib><creatorcontrib>LAMBRETTE, P.</creatorcontrib><creatorcontrib>COSTEA, I.</creatorcontrib><creatorcontrib>KRUPOVES, A.</creatorcontrib><creatorcontrib>FEGURY, H.</creatorcontrib><creatorcontrib>DONG, J.</creatorcontrib><creatorcontrib>GRIMARD, G.</creatorcontrib><creatorcontrib>LEVY, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AMRE, D. K.</au><au>MACK, D. R.</au><au>MORGAN, K.</au><au>ISRAEL, D.</au><au>DESLANDRES, C.</au><au>SEIDMAN, E. G.</au><au>LAMBRETTE, P.</au><au>COSTEA, I.</au><au>KRUPOVES, A.</au><au>FEGURY, H.</au><au>DONG, J.</au><au>GRIMARD, G.</au><au>LEVY, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibility loci reported in genome‐wide association studies are associated with Crohn’s disease in Canadian children</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2010-06</date><risdate>2010</risdate><volume>31</volume><issue>11</issue><spage>1186</spage><epage>1191</epage><pages>1186-1191</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Aliment Pharmacol Ther 31, 1186–1191
Summary
Background Recent genome‐wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn’s disease (CD).
Aims To investigate whether reported genes/loci were also associated with CD in Canadian children.
Design and Methods A case‐control design was implemented at three paediatric gastroenterology clinics in Canada. Children ≤18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome‐wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined.
Results A total of 406 cases and 415 controls were studied. The mean (±s.d.) age of the cases was 12.3 (±3.2) years. Most cases were male (56.6%), had ileo‐colonic disease (L3 ± L4, 52.0%) and inflammatory behaviour (B1 ± p, 86.9%) at diagnosis. Allelic association analysis (two‐tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement.
Conclusion The identified susceptibility genes/loci for adult‐onset CD also confer risk for paediatric‐onset CD.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20222910</pmid><doi>10.1111/j.1365-2036.2010.04294.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Age of Onset Biological and medical sciences Canada - epidemiology Case-Control Studies Child Child, Preschool Crohn Disease - epidemiology Crohn Disease - genetics Digestive system Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Loci - genetics Genetic Predisposition to Disease - epidemiology Genome Genome-Wide Association Study Genotype Humans Male Medical sciences Other diseases. Semiology Pharmacology. Drug treatments Polymorphism, Single Nucleotide Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Susceptibility loci reported in genome‐wide association studies are associated with Crohn’s disease in Canadian children |
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