Risk of CIN2 in Women With a Pap Test Without Endocervical Cells vs. Those With a Negative Pap Test With Endocervical Cells: A Cohort Study with 4.5 Years of Follow-up
To measure the risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in the 4.5 years following a negative Pap smear with adequate endocervical cells (ECC) (+) or absent/scarce ECC (-). A prospective, nonconcurrent study of the archives of 11 Italian population-based screening program...
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| Veröffentlicht in: | Acta cytologica 2010-05, Vol.54 (3), p.265-271 |
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| creator | GIORGI ROSSI, Paolo BAIOCCHI, Diego CIATTO, Stefano |
| description | To measure the risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in the 4.5 years following a negative Pap smear with adequate endocervical cells (ECC) (+) or absent/scarce ECC (-).
A prospective, nonconcurrent study of the archives of 11 Italian population-based screening programs was conducted. Only 25-50-year-old women with a first negative Pap test were included.
Women were classified as ECC+ or ECC- and followed for 4.5 years. The endpoint was the occurrence of a CIN2+ histologic diagnosis. Eligible subjects with negative Pap tests ECC+ and ECC- numbered 469,694 and 20,596, respectively. At least 1 subsequent test was available during follow-up for 335,763 and 11,972 subjects, and 691 and 13 CIN2+ lesions were observed, respectively. The risk of CIN2+ was 2.06 and 1.09 per 1,000 women over 4.5 years, and age-adjusted relative risk associated with ECC--was 0.55 (95% CI 0.28-1.06).
Women with a negative Pap ECC--have a lower risk of CIN2+ than women with a negative Pap ECC+ and should repeat screening with frequency (3-5 years in Europe), independent of age. |
| doi_str_mv | 10.1159/000325033 |
| format | Article |
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A prospective, nonconcurrent study of the archives of 11 Italian population-based screening programs was conducted. Only 25-50-year-old women with a first negative Pap test were included.
Women were classified as ECC+ or ECC- and followed for 4.5 years. The endpoint was the occurrence of a CIN2+ histologic diagnosis. Eligible subjects with negative Pap tests ECC+ and ECC- numbered 469,694 and 20,596, respectively. At least 1 subsequent test was available during follow-up for 335,763 and 11,972 subjects, and 691 and 13 CIN2+ lesions were observed, respectively. The risk of CIN2+ was 2.06 and 1.09 per 1,000 women over 4.5 years, and age-adjusted relative risk associated with ECC--was 0.55 (95% CI 0.28-1.06).
Women with a negative Pap ECC--have a lower risk of CIN2+ than women with a negative Pap ECC+ and should repeat screening with frequency (3-5 years in Europe), independent of age.</description><identifier>ISSN: 0001-5547</identifier><identifier>EISSN: 1938-2650</identifier><identifier>DOI: 10.1159/000325033</identifier><identifier>PMID: 20518409</identifier><identifier>CODEN: ACYTAN</identifier><language>eng</language><publisher>Basel: Karger</publisher><subject>Adult ; Biological and medical sciences ; Cervical Intraepithelial Neoplasia - epidemiology ; Cervical Intraepithelial Neoplasia - pathology ; Cervix Uteri - pathology ; Female ; Female genital diseases ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Italy - epidemiology ; Mass Screening - standards ; Medical sciences ; Middle Aged ; Papanicolaou Test ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Professional Practice ; Prospective Studies ; Risk Factors ; Specimen Handling - standards ; Tumors ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - pathology ; Vaginal Smears - standards</subject><ispartof>Acta cytologica, 2010-05, Vol.54 (3), p.265-271</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22806393$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20518409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GIORGI ROSSI, Paolo</creatorcontrib><creatorcontrib>BAIOCCHI, Diego</creatorcontrib><creatorcontrib>CIATTO, Stefano</creatorcontrib><creatorcontrib>Endocervical Cell Italian Working Group of Cervical Cancer Screening Group</creatorcontrib><title>Risk of CIN2 in Women With a Pap Test Without Endocervical Cells vs. Those With a Negative Pap Test With Endocervical Cells: A Cohort Study with 4.5 Years of Follow-up</title><title>Acta cytologica</title><addtitle>Acta Cytol</addtitle><description>To measure the risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in the 4.5 years following a negative Pap smear with adequate endocervical cells (ECC) (+) or absent/scarce ECC (-).
A prospective, nonconcurrent study of the archives of 11 Italian population-based screening programs was conducted. Only 25-50-year-old women with a first negative Pap test were included.
Women were classified as ECC+ or ECC- and followed for 4.5 years. The endpoint was the occurrence of a CIN2+ histologic diagnosis. Eligible subjects with negative Pap tests ECC+ and ECC- numbered 469,694 and 20,596, respectively. At least 1 subsequent test was available during follow-up for 335,763 and 11,972 subjects, and 691 and 13 CIN2+ lesions were observed, respectively. The risk of CIN2+ was 2.06 and 1.09 per 1,000 women over 4.5 years, and age-adjusted relative risk associated with ECC--was 0.55 (95% CI 0.28-1.06).
Women with a negative Pap ECC--have a lower risk of CIN2+ than women with a negative Pap ECC+ and should repeat screening with frequency (3-5 years in Europe), independent of age.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cervical Intraepithelial Neoplasia - epidemiology</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervix Uteri - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Italy - epidemiology</subject><subject>Mass Screening - standards</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Papanicolaou Test</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Professional Practice</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Specimen Handling - standards</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Vaginal Smears - standards</subject><issn>0001-5547</issn><issn>1938-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9Kw0AQxhdRbK0efAHZi3hK3c1mN4m3ElotlCoaEE9hs39sNM3GbNLSJ_I13WqLCF6-YYbfN3wzAJxjNMSYxtcIIeJTRMgB6OOYRJ7PKDoEfTfHHqVB2AMn1r45ijBGjkHPRxRHAYr74POxsO_QaJhM5z4sKvhslspp0S4ghw-8hqmy7XdvuhaOK2mEalaF4CVMVFlauLJDmC6MVXvTXL3ytlipv-5_rDdwBBOzME0Ln9pObuB6ywVDCl8Ub-w21cSUpVl7XX0KjjQvrTrb1QFIJ-M0ufNm97fTZDTzaj9ArRfonIsQ575gIpDSR5LGSIqIx0xGuRMpWaxlThzE8pzFAoVUS50LpZHWZACuftbWjfnoXPZsWVjhwvJKmc5mISGY0BAHjrzYkV2-VDKrm2LJm022f60DLncAt-5k3fBKFPaX8yPESEzIF8VShyw</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>GIORGI ROSSI, Paolo</creator><creator>BAIOCCHI, Diego</creator><creator>CIATTO, Stefano</creator><general>Karger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Risk of CIN2 in Women With a Pap Test Without Endocervical Cells vs. Those With a Negative Pap Test With Endocervical Cells: A Cohort Study with 4.5 Years of Follow-up</title><author>GIORGI ROSSI, Paolo ; BAIOCCHI, Diego ; CIATTO, Stefano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-4fbac71b2c6c4dd20d590dc8a96d8b96ddd69fdb3c716bb69c075fdfbcef0ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cervical Intraepithelial Neoplasia - epidemiology</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervix Uteri - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Italy - epidemiology</topic><topic>Mass Screening - standards</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Papanicolaou Test</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Professional Practice</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Specimen Handling - standards</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Vaginal Smears - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GIORGI ROSSI, Paolo</creatorcontrib><creatorcontrib>BAIOCCHI, Diego</creatorcontrib><creatorcontrib>CIATTO, Stefano</creatorcontrib><creatorcontrib>Endocervical Cell Italian Working Group of Cervical Cancer Screening Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cytologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GIORGI ROSSI, Paolo</au><au>BAIOCCHI, Diego</au><au>CIATTO, Stefano</au><aucorp>Endocervical Cell Italian Working Group of Cervical Cancer Screening Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of CIN2 in Women With a Pap Test Without Endocervical Cells vs. Those With a Negative Pap Test With Endocervical Cells: A Cohort Study with 4.5 Years of Follow-up</atitle><jtitle>Acta cytologica</jtitle><addtitle>Acta Cytol</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>54</volume><issue>3</issue><spage>265</spage><epage>271</epage><pages>265-271</pages><issn>0001-5547</issn><eissn>1938-2650</eissn><coden>ACYTAN</coden><abstract>To measure the risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in the 4.5 years following a negative Pap smear with adequate endocervical cells (ECC) (+) or absent/scarce ECC (-).
A prospective, nonconcurrent study of the archives of 11 Italian population-based screening programs was conducted. Only 25-50-year-old women with a first negative Pap test were included.
Women were classified as ECC+ or ECC- and followed for 4.5 years. The endpoint was the occurrence of a CIN2+ histologic diagnosis. Eligible subjects with negative Pap tests ECC+ and ECC- numbered 469,694 and 20,596, respectively. At least 1 subsequent test was available during follow-up for 335,763 and 11,972 subjects, and 691 and 13 CIN2+ lesions were observed, respectively. The risk of CIN2+ was 2.06 and 1.09 per 1,000 women over 4.5 years, and age-adjusted relative risk associated with ECC--was 0.55 (95% CI 0.28-1.06).
Women with a negative Pap ECC--have a lower risk of CIN2+ than women with a negative Pap ECC+ and should repeat screening with frequency (3-5 years in Europe), independent of age.</abstract><cop>Basel</cop><pub>Karger</pub><pmid>20518409</pmid><doi>10.1159/000325033</doi><tpages>7</tpages></addata></record> |
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| source | Karger Journals; MEDLINE |
| subjects | Adult Biological and medical sciences Cervical Intraepithelial Neoplasia - epidemiology Cervical Intraepithelial Neoplasia - pathology Cervix Uteri - pathology Female Female genital diseases Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Italy - epidemiology Mass Screening - standards Medical sciences Middle Aged Papanicolaou Test Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Professional Practice Prospective Studies Risk Factors Specimen Handling - standards Tumors Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - pathology Vaginal Smears - standards |
| title | Risk of CIN2 in Women With a Pap Test Without Endocervical Cells vs. Those With a Negative Pap Test With Endocervical Cells: A Cohort Study with 4.5 Years of Follow-up |
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