Do UCP2 and mild uncoupling improve longevity?

Mild uncoupling of mitochondrial respiration is considered to prolong life span of organisms by reducing the production of reactive oxygen species (ROS). Experimental evidence against this hypothesis has been brought forward by premature senescence in cell cultures treated with uncouplers. Exposing...

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Veröffentlicht in:	Experimental gerontology 2010-08, Vol.45 (7-8), p.586-595
Hauptverfasser:	Dikov, Daniel, Aulbach, Angelique, Muster, Britta, Dröse, Stefan, Jendrach, Marina, Bereiter-Hahn, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Avian Proteins - metabolism Base Sequence Catalase - genetics Cell Proliferation Cell Respiration Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - genetics Cellular Senescence - physiology Chick Embryo DNA Primers - genetics Fatty acids Fatty Acids - metabolism Fatty Acids - pharmacology Glutathione Peroxidase - genetics HeLa Cells Humans HUVEC Ion Channels - genetics Ion Channels - metabolism Longevity Membrane Potential, Mitochondrial Mitochondria - metabolism Mitochondrial membrane potential Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mitochondrial Uncoupling Proteins Reactive Oxygen Species - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism ROS Superoxide Dismutase - genetics Superoxide Dismutase-1 Transfection UCP2/3 Uncoupler Uncoupling Protein 2 Uncoupling Protein 3
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