A fundamental investigation into the effects of eutectic formation on transmembrane transport

Eutectic systems enhance the permeation of therapeutic agents across biological barriers, but the mechanism by which this occurs has not previously been elucidated. Using human skin it has proven difficult to isolate the fundamental effects of eutectic formation on molecule diffusion and partition f...

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Veröffentlicht in:	International journal of pharmaceutics 2010-06, Vol.393 (1), p.68-73
Hauptverfasser:	Fiala, Sarah, Jones, Stuart A., Brown, Marc B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Combined - chemistry Anesthetics, Combined - metabolism Anesthetics, Local - chemistry Anesthetics, Local - metabolism Biological and medical sciences Biological Transport Cell Membrane Permeability Chemistry, Pharmaceutical Diffusion Drug Compounding Eutectic General pharmacology Hydrophobic and Hydrophilic Interactions Kinetics Lidocaine Lidocaine - chemistry Lidocaine - metabolism Medical sciences Membranes, Artificial Permeation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Prilocaine Prilocaine - chemistry Prilocaine - metabolism Silicone membrane Silicones Solubility Technology, Pharmaceutical - methods
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