The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Hippocampal Volume, and Cognitive Function in Geriatric Depression

Objective The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with geriatric depression. In studies of younger adults without depression, met allele carriers exhibit smaller hippocampal volumes and have poorer performance on neuropsychological tests. The auth...

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Veröffentlicht in:	The American journal of geriatric psychiatry 2010-04, Vol.18 (4), p.323-331
Hauptverfasser:	Benjamin, Sophiya, M.D, McQuoid, Douglas R., M.S, Potter, Guy G., Ph.D, Payne, Martha E., Ph.D., M.P.H., R.D, MacFall, James R., Ph.D, Steffens, David C., M.D., M.H.S, Taylor, Warren D., M.D., M.H.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Brain-Derived Neurotrophic Factor - genetics Cognition depression Depression - genetics Depression - pathology Depression - psychology Female Genetic polymorphism Genetic Predisposition to Disease hippocampus Hippocampus - pathology Humans Internal Medicine Middle Aged MRI Polymorphism, Genetic Psychomotor Performance
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