Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle

Myostatin (MSTN) is a negative regulator during muscle differentiation, whereas insulin-like growth factors (IGFs) are essential for muscle development. MSTN and IGFs act oppositely during myogenesis, but there is little information on the mutual relationship of MSTN and IGFs. The present study was...

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Veröffentlicht in:	Animal science journal 2010-04, Vol.81 (2), p.223-229
Hauptverfasser:	Miyake, Masato, Hayashi, Shinichiro, Taketa, Yoshikazu, Iwasaki, Shunsuke, Watanabe, Kouichi, Ohwada, Shyuich, Aso, Hisashi, Yamaguchi, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors - metabolism Animal sciences Animals Cattle Cattle - metabolism Cell culture double-muscled cattle Down-Regulation Gene expression insulin-like growth factor Insulin-Like Growth Factor II - metabolism Insulin-like growth factors Kinases muscle development Muscle Development - drug effects myogenesis myostatin Myostatin - pharmacology Signal Transduction Smad Proteins - metabolism Smad signaling
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