Acute cold-induced thermogenesis in neonatal chicks ( Gallus gallus)
Mechanisms of thermogenic responses that play a role to maintain homeothermy during an early stage of neonatal chicks on acute cold exposure are scarcely studied as hatchlings are believed to be poikilothermic. However, chicks can attain the homeothermy during their subsequent growth after hatching....
Gespeichert in:
| Veröffentlicht in: | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2010-05, Vol.156 (1), p.34-41 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 41 |
|---|---|
| container_issue | 1 |
| container_start_page | 34 |
| container_title | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology |
| container_volume | 156 |
| creator | Mujahid, Ahmad |
| description | Mechanisms of thermogenic responses that play a role to maintain homeothermy during an early stage of neonatal chicks on acute cold exposure are scarcely studied as hatchlings are believed to be poikilothermic. However, chicks can attain the homeothermy during their subsequent growth after hatching. To identify thermogenic responses during neonatal stages of chicks (
Gallus gallus) on acute cold exposure (12
°C, 3
h), changes in plasma corticosterone levels, thermogenesis, gene transcripts (avUCP and avPGC1α) in skeletal muscles (
pectoralis superficialis and
gastrocnemius) and mitochondrial substrate oxidation enzyme activities in dissected tissues of 1- and 4-d-old chicks were studied. Results revealed that 1-day-old neonatal chicks were particularly vulnerable to cold exposure and were hypothermic. However, 4-d-old cold-exposed chicks maintained thermostability with significantly higher plasma corticosterone levels, oxygen consumption, heat production, and increased mitochondrial substrate oxidation enzyme activities (CS and 3HADH) in different dissected tissues. Analysis of gene transcripts for avian peroxisome-proliferator-activated receptor-γ co-activator-1α (avPGC1α) and avian uncoupling protein (avUCP) in skeletal muscles revealed no significant change between cold-sensitive (1-d-old) and cold-tolerant (4-d-old) neonatal chicks, and failed to explain the enhanced thermogenesis and tolerance to acute cold. Additionally, avPGC1α gene transcripts were not correlated with the increased enzyme activities of CS or 3HADH in skeletal muscle. In conclusion, these data suggest the possible role of HPA-axis in cold-tolerant neonatal chicks to modulate substrate mobilization and oxidation. The thermogenic mechanisms based in part upon the increased capacity for mitochondrial substrate oxidation in different tissues are associated with enhanced heat production to attain homeothermy and acquire tolerance to acute cold exposure during an early stage of neonatal chicks. |
| doi_str_mv | 10.1016/j.cbpa.2009.12.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733132947</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S109564330901201X</els_id><sourcerecordid>733132947</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-33bc4153d46d3e1efe9029b4760dea03f040d1ed806826446b4c3248c73c24a83</originalsourceid><addsrcrecordid>eNp9kElPwzAQhS0EomX5AxyQb8AhYbw0i8SlKlCQKnGBs-XYk9YlS4kTJP49Li0cmcvMSO89zXyEXDCIGbDkdh2bYqNjDpDHjMcA8oCM2USwSArBD8MM-SRKwjIiJ96vIZRk8piMgoVP8hzG5H5qhh6paSsbucYOBi3tV9jV7RIb9M5T19AG20b3uqJm5cy7p9d0rqtq8HT5027OyFGpK4_n-35K3h4fXmdP0eJl_jybLiIjOesjIQojw31WJlYgwxJz4Hkh0wQsahAlSLAMbQZJxhMpk0IawWVmUmG41Jk4JVe73E3Xfgzoe1U7b7CqdLhw8CoVggmeyzQo-U5putb7Dku16Vytuy_FQG3hqbXawlNbeIpxFcgE0-U-fihqtH-WX1pBcLcTYHjy02GnvHHYBGauQ9Mr27r_8r8BVcx-ZA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733132947</pqid></control><display><type>article</type><title>Acute cold-induced thermogenesis in neonatal chicks ( Gallus gallus)</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Mujahid, Ahmad</creator><creatorcontrib>Mujahid, Ahmad</creatorcontrib><description>Mechanisms of thermogenic responses that play a role to maintain homeothermy during an early stage of neonatal chicks on acute cold exposure are scarcely studied as hatchlings are believed to be poikilothermic. However, chicks can attain the homeothermy during their subsequent growth after hatching. To identify thermogenic responses during neonatal stages of chicks (
Gallus gallus) on acute cold exposure (12
°C, 3
h), changes in plasma corticosterone levels, thermogenesis, gene transcripts (avUCP and avPGC1α) in skeletal muscles (
pectoralis superficialis and
gastrocnemius) and mitochondrial substrate oxidation enzyme activities in dissected tissues of 1- and 4-d-old chicks were studied. Results revealed that 1-day-old neonatal chicks were particularly vulnerable to cold exposure and were hypothermic. However, 4-d-old cold-exposed chicks maintained thermostability with significantly higher plasma corticosterone levels, oxygen consumption, heat production, and increased mitochondrial substrate oxidation enzyme activities (CS and 3HADH) in different dissected tissues. Analysis of gene transcripts for avian peroxisome-proliferator-activated receptor-γ co-activator-1α (avPGC1α) and avian uncoupling protein (avUCP) in skeletal muscles revealed no significant change between cold-sensitive (1-d-old) and cold-tolerant (4-d-old) neonatal chicks, and failed to explain the enhanced thermogenesis and tolerance to acute cold. Additionally, avPGC1α gene transcripts were not correlated with the increased enzyme activities of CS or 3HADH in skeletal muscle. In conclusion, these data suggest the possible role of HPA-axis in cold-tolerant neonatal chicks to modulate substrate mobilization and oxidation. The thermogenic mechanisms based in part upon the increased capacity for mitochondrial substrate oxidation in different tissues are associated with enhanced heat production to attain homeothermy and acquire tolerance to acute cold exposure during an early stage of neonatal chicks.</description><identifier>ISSN: 1095-6433</identifier><identifier>EISSN: 1531-4332</identifier><identifier>DOI: 10.1016/j.cbpa.2009.12.004</identifier><identifier>PMID: 20025990</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3-Hydroxyacyl CoA Dehydrogenases - metabolism ; Animals ; Animals, Newborn ; Avian Proteins - genetics ; Chickens - blood ; Chickens - genetics ; Chickens - physiology ; Citrate (si)-Synthase - metabolism ; Cold stress ; Cold Temperature - adverse effects ; Corticosterone - blood ; HPA axis ; Male ; Mitochondrial Proteins - genetics ; Mitochondrial Uncoupling Proteins ; Muscle, Skeletal - metabolism ; Oxygen Consumption ; PGC1α ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Substrate oxidation ; Thermogenesis ; Thermogenesis - genetics ; Thermogenesis - physiology ; Trans-Activators - genetics ; UCP</subject><ispartof>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2010-05, Vol.156 (1), p.34-41</ispartof><rights>2010 Elsevier Inc.</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-33bc4153d46d3e1efe9029b4760dea03f040d1ed806826446b4c3248c73c24a83</citedby><cites>FETCH-LOGICAL-c421t-33bc4153d46d3e1efe9029b4760dea03f040d1ed806826446b4c3248c73c24a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpa.2009.12.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20025990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mujahid, Ahmad</creatorcontrib><title>Acute cold-induced thermogenesis in neonatal chicks ( Gallus gallus)</title><title>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</title><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><description>Mechanisms of thermogenic responses that play a role to maintain homeothermy during an early stage of neonatal chicks on acute cold exposure are scarcely studied as hatchlings are believed to be poikilothermic. However, chicks can attain the homeothermy during their subsequent growth after hatching. To identify thermogenic responses during neonatal stages of chicks (
Gallus gallus) on acute cold exposure (12
°C, 3
h), changes in plasma corticosterone levels, thermogenesis, gene transcripts (avUCP and avPGC1α) in skeletal muscles (
pectoralis superficialis and
gastrocnemius) and mitochondrial substrate oxidation enzyme activities in dissected tissues of 1- and 4-d-old chicks were studied. Results revealed that 1-day-old neonatal chicks were particularly vulnerable to cold exposure and were hypothermic. However, 4-d-old cold-exposed chicks maintained thermostability with significantly higher plasma corticosterone levels, oxygen consumption, heat production, and increased mitochondrial substrate oxidation enzyme activities (CS and 3HADH) in different dissected tissues. Analysis of gene transcripts for avian peroxisome-proliferator-activated receptor-γ co-activator-1α (avPGC1α) and avian uncoupling protein (avUCP) in skeletal muscles revealed no significant change between cold-sensitive (1-d-old) and cold-tolerant (4-d-old) neonatal chicks, and failed to explain the enhanced thermogenesis and tolerance to acute cold. Additionally, avPGC1α gene transcripts were not correlated with the increased enzyme activities of CS or 3HADH in skeletal muscle. In conclusion, these data suggest the possible role of HPA-axis in cold-tolerant neonatal chicks to modulate substrate mobilization and oxidation. The thermogenic mechanisms based in part upon the increased capacity for mitochondrial substrate oxidation in different tissues are associated with enhanced heat production to attain homeothermy and acquire tolerance to acute cold exposure during an early stage of neonatal chicks.</description><subject>3-Hydroxyacyl CoA Dehydrogenases - metabolism</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Avian Proteins - genetics</subject><subject>Chickens - blood</subject><subject>Chickens - genetics</subject><subject>Chickens - physiology</subject><subject>Citrate (si)-Synthase - metabolism</subject><subject>Cold stress</subject><subject>Cold Temperature - adverse effects</subject><subject>Corticosterone - blood</subject><subject>HPA axis</subject><subject>Male</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Mitochondrial Uncoupling Proteins</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Oxygen Consumption</subject><subject>PGC1α</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Substrate oxidation</subject><subject>Thermogenesis</subject><subject>Thermogenesis - genetics</subject><subject>Thermogenesis - physiology</subject><subject>Trans-Activators - genetics</subject><subject>UCP</subject><issn>1095-6433</issn><issn>1531-4332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElPwzAQhS0EomX5AxyQb8AhYbw0i8SlKlCQKnGBs-XYk9YlS4kTJP49Li0cmcvMSO89zXyEXDCIGbDkdh2bYqNjDpDHjMcA8oCM2USwSArBD8MM-SRKwjIiJ96vIZRk8piMgoVP8hzG5H5qhh6paSsbucYOBi3tV9jV7RIb9M5T19AG20b3uqJm5cy7p9d0rqtq8HT5027OyFGpK4_n-35K3h4fXmdP0eJl_jybLiIjOesjIQojw31WJlYgwxJz4Hkh0wQsahAlSLAMbQZJxhMpk0IawWVmUmG41Jk4JVe73E3Xfgzoe1U7b7CqdLhw8CoVggmeyzQo-U5putb7Dku16Vytuy_FQG3hqbXawlNbeIpxFcgE0-U-fihqtH-WX1pBcLcTYHjy02GnvHHYBGauQ9Mr27r_8r8BVcx-ZA</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Mujahid, Ahmad</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Acute cold-induced thermogenesis in neonatal chicks ( Gallus gallus)</title><author>Mujahid, Ahmad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-33bc4153d46d3e1efe9029b4760dea03f040d1ed806826446b4c3248c73c24a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>3-Hydroxyacyl CoA Dehydrogenases - metabolism</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Avian Proteins - genetics</topic><topic>Chickens - blood</topic><topic>Chickens - genetics</topic><topic>Chickens - physiology</topic><topic>Citrate (si)-Synthase - metabolism</topic><topic>Cold stress</topic><topic>Cold Temperature - adverse effects</topic><topic>Corticosterone - blood</topic><topic>HPA axis</topic><topic>Male</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Mitochondrial Uncoupling Proteins</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Oxygen Consumption</topic><topic>PGC1α</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Substrate oxidation</topic><topic>Thermogenesis</topic><topic>Thermogenesis - genetics</topic><topic>Thermogenesis - physiology</topic><topic>Trans-Activators - genetics</topic><topic>UCP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mujahid, Ahmad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mujahid, Ahmad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute cold-induced thermogenesis in neonatal chicks ( Gallus gallus)</atitle><jtitle>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</jtitle><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>156</volume><issue>1</issue><spage>34</spage><epage>41</epage><pages>34-41</pages><issn>1095-6433</issn><eissn>1531-4332</eissn><abstract>Mechanisms of thermogenic responses that play a role to maintain homeothermy during an early stage of neonatal chicks on acute cold exposure are scarcely studied as hatchlings are believed to be poikilothermic. However, chicks can attain the homeothermy during their subsequent growth after hatching. To identify thermogenic responses during neonatal stages of chicks (
Gallus gallus) on acute cold exposure (12
°C, 3
h), changes in plasma corticosterone levels, thermogenesis, gene transcripts (avUCP and avPGC1α) in skeletal muscles (
pectoralis superficialis and
gastrocnemius) and mitochondrial substrate oxidation enzyme activities in dissected tissues of 1- and 4-d-old chicks were studied. Results revealed that 1-day-old neonatal chicks were particularly vulnerable to cold exposure and were hypothermic. However, 4-d-old cold-exposed chicks maintained thermostability with significantly higher plasma corticosterone levels, oxygen consumption, heat production, and increased mitochondrial substrate oxidation enzyme activities (CS and 3HADH) in different dissected tissues. Analysis of gene transcripts for avian peroxisome-proliferator-activated receptor-γ co-activator-1α (avPGC1α) and avian uncoupling protein (avUCP) in skeletal muscles revealed no significant change between cold-sensitive (1-d-old) and cold-tolerant (4-d-old) neonatal chicks, and failed to explain the enhanced thermogenesis and tolerance to acute cold. Additionally, avPGC1α gene transcripts were not correlated with the increased enzyme activities of CS or 3HADH in skeletal muscle. In conclusion, these data suggest the possible role of HPA-axis in cold-tolerant neonatal chicks to modulate substrate mobilization and oxidation. The thermogenic mechanisms based in part upon the increased capacity for mitochondrial substrate oxidation in different tissues are associated with enhanced heat production to attain homeothermy and acquire tolerance to acute cold exposure during an early stage of neonatal chicks.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20025990</pmid><doi>10.1016/j.cbpa.2009.12.004</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1095-6433 |
| ispartof | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2010-05, Vol.156 (1), p.34-41 |
| issn | 1095-6433 1531-4332 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733132947 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 3-Hydroxyacyl CoA Dehydrogenases - metabolism Animals Animals, Newborn Avian Proteins - genetics Chickens - blood Chickens - genetics Chickens - physiology Citrate (si)-Synthase - metabolism Cold stress Cold Temperature - adverse effects Corticosterone - blood HPA axis Male Mitochondrial Proteins - genetics Mitochondrial Uncoupling Proteins Muscle, Skeletal - metabolism Oxygen Consumption PGC1α RNA, Messenger - genetics RNA, Messenger - metabolism Substrate oxidation Thermogenesis Thermogenesis - genetics Thermogenesis - physiology Trans-Activators - genetics UCP |
| title | Acute cold-induced thermogenesis in neonatal chicks ( Gallus gallus) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T04%3A08%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20cold-induced%20thermogenesis%20in%20neonatal%20chicks%20(%20Gallus%20gallus)&rft.jtitle=Comparative%20biochemistry%20and%20physiology.%20Part%20A,%20Molecular%20&%20integrative%20physiology&rft.au=Mujahid,%20Ahmad&rft.date=2010-05-01&rft.volume=156&rft.issue=1&rft.spage=34&rft.epage=41&rft.pages=34-41&rft.issn=1095-6433&rft.eissn=1531-4332&rft_id=info:doi/10.1016/j.cbpa.2009.12.004&rft_dat=%3Cproquest_cross%3E733132947%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733132947&rft_id=info:pmid/20025990&rft_els_id=S109564330901201X&rfr_iscdi=true |