The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats
The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morp...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2010-04, Vol.23 (2), p.170-174 |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Sepehri, Gholamreza Sheibani, Vahid Azarang, Afrooz Shamsizadeh, Ali Afarinesh, Mohammad Reza Azizollahi, Saeed Sepehri, Ehsan |
| description | The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 (0.25, 0.5 and 1 micromol/rat) was injected through ICV. Maximal possible effect percentage (MPE %) was considered as analgesia index. Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 micromol/rat) decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes. |
| format | Article |
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This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 (0.25, 0.5 and 1 micromol/rat) was injected through ICV. Maximal possible effect percentage (MPE %) was considered as analgesia index. Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 micromol/rat) decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 20363694</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Analgesics, Opioid - pharmacology ; Animals ; Calcium-binding proteins ; Calmodulin ; Calmodulin - antagonists & inhibitors ; Calmodulin - physiology ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug Tolerance - physiology ; Enzyme Inhibitors - pharmacology ; Injections, Intraventricular ; Male ; Morphine ; Morphine - pharmacology ; Pain Threshold - drug effects ; Rats ; Rats, Wistar ; Sulfonamides - administration & dosage ; Sulfonamides - pharmacology</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2010-04, Vol.23 (2), p.170-174</ispartof><rights>COPYRIGHT 2010 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20363694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sepehri, Gholamreza</creatorcontrib><creatorcontrib>Sheibani, Vahid</creatorcontrib><creatorcontrib>Azarang, Afrooz</creatorcontrib><creatorcontrib>Shamsizadeh, Ali</creatorcontrib><creatorcontrib>Afarinesh, Mohammad Reza</creatorcontrib><creatorcontrib>Azizollahi, Saeed</creatorcontrib><creatorcontrib>Sepehri, Ehsan</creatorcontrib><title>The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 (0.25, 0.5 and 1 micromol/rat) was injected through ICV. Maximal possible effect percentage (MPE %) was considered as analgesia index. Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 micromol/rat) decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes.</description><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Calcium-binding proteins</subject><subject>Calmodulin</subject><subject>Calmodulin - antagonists & inhibitors</subject><subject>Calmodulin - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Drug Tolerance - physiology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Pain Threshold - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sulfonamides - administration & dosage</subject><subject>Sulfonamides - pharmacology</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkctKAzEUhmehaK2-ggRcqOBIJplLsizFS6HgxttuyExObCST1CQj-Ai-tSmtC0GyOOTnO98JOXvZpMBFkde4eD3MjkJ4x7guOecH2SHBtKY1LyfZ9-MKkLbRix48dN59QrrofjTCo4vF_PkSCTloq0NConYWOYVe8uYKCdQLMzg5Gm2TYaU7HZ1PeYxgRxEhoJjcEj7BuPWQtJvWwfn1SltA0Rnwwvab6Sipw3G2r4QJcLKr0-zp9uZxfp8vH-4W89kyfyNNE_OKVLKihBJVASnLiteccMZUR-oOM9KVTGHec8kaXJaUUykxU72UjBaNUrWk0-x861179zFCiO2gQw_GCAtuDG1DaUEJqZtEnm3JN2Gg1Va5zTdt6HZGeMk4qzBJ1PU_VDoSBt07C0qn_E_D6e4BYzeAbNdeD8J_tb9LoT-oJYdc</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Sepehri, Gholamreza</creator><creator>Sheibani, Vahid</creator><creator>Azarang, Afrooz</creator><creator>Shamsizadeh, Ali</creator><creator>Afarinesh, Mohammad Reza</creator><creator>Azizollahi, Saeed</creator><creator>Sepehri, Ehsan</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats</title><author>Sepehri, Gholamreza ; Sheibani, Vahid ; Azarang, Afrooz ; Shamsizadeh, Ali ; Afarinesh, Mohammad Reza ; Azizollahi, Saeed ; Sepehri, Ehsan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g277t-525d53232f5e24459692988fb26b082b48f09c9d87044393dd08fcdd8317ff6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Calcium-binding proteins</topic><topic>Calmodulin</topic><topic>Calmodulin - antagonists & inhibitors</topic><topic>Calmodulin - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Drug Tolerance - physiology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Pain Threshold - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sulfonamides - administration & dosage</topic><topic>Sulfonamides - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sepehri, Gholamreza</creatorcontrib><creatorcontrib>Sheibani, Vahid</creatorcontrib><creatorcontrib>Azarang, Afrooz</creatorcontrib><creatorcontrib>Shamsizadeh, Ali</creatorcontrib><creatorcontrib>Afarinesh, Mohammad Reza</creatorcontrib><creatorcontrib>Azizollahi, Saeed</creatorcontrib><creatorcontrib>Sepehri, Ehsan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sepehri, Gholamreza</au><au>Sheibani, Vahid</au><au>Azarang, Afrooz</au><au>Shamsizadeh, Ali</au><au>Afarinesh, Mohammad Reza</au><au>Azizollahi, Saeed</au><au>Sepehri, Ehsan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2010-04</date><risdate>2010</risdate><volume>23</volume><issue>2</issue><spage>170</spage><epage>174</epage><pages>170-174</pages><issn>1011-601X</issn><abstract>The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 (0.25, 0.5 and 1 micromol/rat) was injected through ICV. Maximal possible effect percentage (MPE %) was considered as analgesia index. Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 micromol/rat) decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>20363694</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Pakistan journal of pharmaceutical sciences, 2010-04, Vol.23 (2), p.170-174 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analgesics, Opioid - pharmacology Animals Calcium-binding proteins Calmodulin Calmodulin - antagonists & inhibitors Calmodulin - physiology Dose-Response Relationship, Drug Drug Interactions Drug Tolerance - physiology Enzyme Inhibitors - pharmacology Injections, Intraventricular Male Morphine Morphine - pharmacology Pain Threshold - drug effects Rats Rats, Wistar Sulfonamides - administration & dosage Sulfonamides - pharmacology |
| title | The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats |
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