Antagonistic Activity of Y-25130 on 5-HT3 Receptors

This paper describes the 5-hydroxytryptamine3 (5-HT3) receptor antagonism of Y-25130 ((±)-N-(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-l,4-benzoxazine-8-carboxamide monohydrochloride) in the rat cerebral cortex, isolated rabbit heart and isolated guinea pig ileum. In an in...

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Veröffentlicht in:	Japanese journal of pharmacology 1992, Vol.59(4), pp.443-448
Hauptverfasser:	Sato, Noriko, Sakamori, Masamitsu, Haga, Keiichiro, Takehara, Shuzo, Setoguchi, Michihide
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT3 receptor Acetylcholine - metabolism Animals Antiemetics - metabolism Antiemetics - pharmacology Biological and medical sciences Bridged Bicyclo Compounds - metabolism Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic Cardiotonic Agents - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - ultrastructure Guinea Pigs Heart (isolated) Heart - drug effects Heart - physiology Ileum (isolated) Ileum - drug effects Ileum - metabolism Ileum - ultrastructure In Vitro Techniques Kinetics Male Medical sciences Muscle Contraction - drug effects Myocardial Contraction - drug effects Myocardium - metabolism Myocardium - ultrastructure Nerve Fibers - drug effects Nerve Fibers - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine - metabolism Oxazines - metabolism Oxazines - pharmacology Pharmacology. Drug treatments Rabbits Radioligand Assay Receptors, Neurotransmitter - metabolism Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Serotonin Antagonists Serotoninergic system Stimulation, Chemical Sympathetic Nervous System - drug effects Sympathetic Nervous System - metabolism Y-25130
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