In Vivo Evaluation of Drug-Drug Interaction via Mechanism-Based Inhibition by Macrolide Antibiotics in Cynomolgus Monkeys

Irreversible inhibition, characterized as mechanism-based inhibition (MBI), of cytochrome P450 in drugs has to be avoided for their safe use. A comprehensive assessment of drug-drug interaction (DDI) potential is important during the drug discovery process. In the present study, we evaluated the eff...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug metabolism and disposition 2009-11, Vol.37 (11), p.2127-2136
Hauptverfasser:	Ogasawara, Akihito, Negishi, Isao, Kozakai, Kazumasa, Kume, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Biological and medical sciences Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Drug Interactions - physiology Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Humans Macaca fascicularis Macrolides - metabolism Macrolides - pharmacology Male Medical sciences Microsomes - drug effects Microsomes - enzymology Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!