A Possible Mechanism for the Differences in Efficiency and Variability of Active Metabolite Formation from Thienopyridine Antiplatelet Agents, Prasugrel and Clopidogrel

The efficiency and interindividual variability in bioactivation of prasugrel and clopidogrel were quantitatively compared and the mechanisms involved were elucidated using 20 individual human liver microsomes. Prasugrel and clopidogrel are converted to their thiol-containing active metabolites throu...

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Veröffentlicht in:	Drug metabolism and disposition 2009-11, Vol.37 (11), p.2145-2152
Hauptverfasser:	Hagihara, Katsunobu, Kazui, Miho, Kurihara, Atsushi, Yoshiike, Michiharu, Honda, Kokichi, Okazaki, Osamu, Farid, Nagy A., Ikeda, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism Genetic Variation - physiology Humans Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - metabolism Pharmacology. Drug treatments Piperazines - chemistry Piperazines - metabolism Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - metabolism Prasugrel Hydrochloride Pyridines - chemistry Pyridines - metabolism Thiophenes - chemistry Thiophenes - metabolism Ticlopidine - analogs & derivatives Ticlopidine - chemistry Ticlopidine - metabolism
Online-Zugang:	Volltext
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