Oxidative damage in Parkinson disease: Measurement using accurate biomarkers
Oxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F 2-isoprostanes (F 2-IsoP...
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| Veröffentlicht in: | Free radical biology & medicine 2010-02, Vol.48 (4), p.560-566 |
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| creator | Seet, Raymond C.S. Lee, Chung-Yung J. Lim, Erle C.H. Tan, June J.H. Quek, Amy M.L. Chong, Wan-Ling Looi, Woan-Foon Huang, Shan-Hong Wang, Huansong Chan, Yiong-Huak Halliwell, Barry |
| description | Oxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F
2-isoprostanes (F
2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F
4-NPs), phospholipase A
2 (PLA
2) and platelet activating factor–acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F
2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F
4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA
2 and PAF-AH activities were lower, in PD patients compared to controls (
p
<
0.05). The levels of plasma F
2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (
p trend
<
0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (
r
=
−0.305,
p
=
0.023) and plasma total HETEs (
r
=
−0.285,
p
=
0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD. |
| doi_str_mv | 10.1016/j.freeradbiomed.2009.11.026 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733130464</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0891584909007394</els_id><sourcerecordid>733130464</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-fb4d0f44bf4e9006a5a38b3604d5be908e6b25055c8fc632e5adafe8063a8d3b3</originalsourceid><addsrcrecordid>eNqNkMtOwzAQRS0EouXxCygSC1YJ4_hRB1ao4iUVwQLWlmNPkEubFDup4O9x1QqJHauRZu6duXMIOadQUKDycl40ATEYV_tuia4oAaqC0gJKuUfGVE1YzkUl98kYVEVzoXg1IkcxzgGAC6YOyYhWlaxgAmMye_7yzvR-jZkzS_OOmW-zFxM-fBu7NnM-ool4lT2lMgRcYttnQ_Tte2asHYLpMdvESAYM8YQcNGYR8XRXj8nb3e3r9CGfPd8_Tm9muWWq7POm5g4azuuGYwUgjTBM1UwCd6JOHYWyLgUIYVVjJStRGGcaVCCZUY7V7JhcbPeuQvc5YOz10keLi4VpsRuinjBGGXDJk_J6q7ShizFgo1fBp7TfmoLe0NRz_Yem3tDUlOpEM7nPdneGejP79e7wJcHtVoDp27XHoKP12Fp0PqDttev8vw79AGGWjvE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733130464</pqid></control><display><type>article</type><title>Oxidative damage in Parkinson disease: Measurement using accurate biomarkers</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Seet, Raymond C.S. ; Lee, Chung-Yung J. ; Lim, Erle C.H. ; Tan, June J.H. ; Quek, Amy M.L. ; Chong, Wan-Ling ; Looi, Woan-Foon ; Huang, Shan-Hong ; Wang, Huansong ; Chan, Yiong-Huak ; Halliwell, Barry</creator><creatorcontrib>Seet, Raymond C.S. ; Lee, Chung-Yung J. ; Lim, Erle C.H. ; Tan, June J.H. ; Quek, Amy M.L. ; Chong, Wan-Ling ; Looi, Woan-Foon ; Huang, Shan-Hong ; Wang, Huansong ; Chan, Yiong-Huak ; Halliwell, Barry</creatorcontrib><description>Oxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F
2-isoprostanes (F
2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F
4-NPs), phospholipase A
2 (PLA
2) and platelet activating factor–acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F
2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F
4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA
2 and PAF-AH activities were lower, in PD patients compared to controls (
p
<
0.05). The levels of plasma F
2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (
p trend
<
0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (
r
=
−0.305,
p
=
0.023) and plasma total HETEs (
r
=
−0.285,
p
=
0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD.</description><identifier>ISSN: 0891-5849</identifier><identifier>EISSN: 1873-4596</identifier><identifier>DOI: 10.1016/j.freeradbiomed.2009.11.026</identifier><identifier>PMID: 19969070</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>8-Hydroxy-2′-deoxyguanosine ; Aged ; Biomarkers - metabolism ; C-Reactive Protein - chemistry ; Case-Control Studies ; Cholesterol - chemistry ; Disease Progression ; DNA - chemistry ; F 2-isoprostanes ; F2-Isoprostanes - chemistry ; Female ; Free radicals ; Humans ; Hydroxyeicosatetraenoic Acids - chemistry ; Levodopa - pharmacology ; Lipids - chemistry ; Male ; Middle Aged ; Neuroprostanes ; Oxidative Stress ; Oxygen - chemistry ; Parkinson disease ; Parkinson Disease - blood ; Parkinson Disease - diagnosis ; Parkinson Disease - pathology</subject><ispartof>Free radical biology & medicine, 2010-02, Vol.48 (4), p.560-566</ispartof><rights>2009 Elsevier Inc.</rights><rights>Copyright 2009 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-fb4d0f44bf4e9006a5a38b3604d5be908e6b25055c8fc632e5adafe8063a8d3b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0891584909007394$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19969070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seet, Raymond C.S.</creatorcontrib><creatorcontrib>Lee, Chung-Yung J.</creatorcontrib><creatorcontrib>Lim, Erle C.H.</creatorcontrib><creatorcontrib>Tan, June J.H.</creatorcontrib><creatorcontrib>Quek, Amy M.L.</creatorcontrib><creatorcontrib>Chong, Wan-Ling</creatorcontrib><creatorcontrib>Looi, Woan-Foon</creatorcontrib><creatorcontrib>Huang, Shan-Hong</creatorcontrib><creatorcontrib>Wang, Huansong</creatorcontrib><creatorcontrib>Chan, Yiong-Huak</creatorcontrib><creatorcontrib>Halliwell, Barry</creatorcontrib><title>Oxidative damage in Parkinson disease: Measurement using accurate biomarkers</title><title>Free radical biology & medicine</title><addtitle>Free Radic Biol Med</addtitle><description>Oxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F
2-isoprostanes (F
2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F
4-NPs), phospholipase A
2 (PLA
2) and platelet activating factor–acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F
2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F
4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA
2 and PAF-AH activities were lower, in PD patients compared to controls (
p
<
0.05). The levels of plasma F
2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (
p trend
<
0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (
r
=
−0.305,
p
=
0.023) and plasma total HETEs (
r
=
−0.285,
p
=
0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD.</description><subject>8-Hydroxy-2′-deoxyguanosine</subject><subject>Aged</subject><subject>Biomarkers - metabolism</subject><subject>C-Reactive Protein - chemistry</subject><subject>Case-Control Studies</subject><subject>Cholesterol - chemistry</subject><subject>Disease Progression</subject><subject>DNA - chemistry</subject><subject>F 2-isoprostanes</subject><subject>F2-Isoprostanes - chemistry</subject><subject>Female</subject><subject>Free radicals</subject><subject>Humans</subject><subject>Hydroxyeicosatetraenoic Acids - chemistry</subject><subject>Levodopa - pharmacology</subject><subject>Lipids - chemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroprostanes</subject><subject>Oxidative Stress</subject><subject>Oxygen - chemistry</subject><subject>Parkinson disease</subject><subject>Parkinson Disease - blood</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - pathology</subject><issn>0891-5849</issn><issn>1873-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EouXxCygSC1YJ4_hRB1ao4iUVwQLWlmNPkEubFDup4O9x1QqJHauRZu6duXMIOadQUKDycl40ATEYV_tuia4oAaqC0gJKuUfGVE1YzkUl98kYVEVzoXg1IkcxzgGAC6YOyYhWlaxgAmMye_7yzvR-jZkzS_OOmW-zFxM-fBu7NnM-ool4lT2lMgRcYttnQ_Tte2asHYLpMdvESAYM8YQcNGYR8XRXj8nb3e3r9CGfPd8_Tm9muWWq7POm5g4azuuGYwUgjTBM1UwCd6JOHYWyLgUIYVVjJStRGGcaVCCZUY7V7JhcbPeuQvc5YOz10keLi4VpsRuinjBGGXDJk_J6q7ShizFgo1fBp7TfmoLe0NRz_Yem3tDUlOpEM7nPdneGejP79e7wJcHtVoDp27XHoKP12Fp0PqDttev8vw79AGGWjvE</recordid><startdate>20100215</startdate><enddate>20100215</enddate><creator>Seet, Raymond C.S.</creator><creator>Lee, Chung-Yung J.</creator><creator>Lim, Erle C.H.</creator><creator>Tan, June J.H.</creator><creator>Quek, Amy M.L.</creator><creator>Chong, Wan-Ling</creator><creator>Looi, Woan-Foon</creator><creator>Huang, Shan-Hong</creator><creator>Wang, Huansong</creator><creator>Chan, Yiong-Huak</creator><creator>Halliwell, Barry</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100215</creationdate><title>Oxidative damage in Parkinson disease: Measurement using accurate biomarkers</title><author>Seet, Raymond C.S. ; Lee, Chung-Yung J. ; Lim, Erle C.H. ; Tan, June J.H. ; Quek, Amy M.L. ; Chong, Wan-Ling ; Looi, Woan-Foon ; Huang, Shan-Hong ; Wang, Huansong ; Chan, Yiong-Huak ; Halliwell, Barry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-fb4d0f44bf4e9006a5a38b3604d5be908e6b25055c8fc632e5adafe8063a8d3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>8-Hydroxy-2′-deoxyguanosine</topic><topic>Aged</topic><topic>Biomarkers - metabolism</topic><topic>C-Reactive Protein - chemistry</topic><topic>Case-Control Studies</topic><topic>Cholesterol - chemistry</topic><topic>Disease Progression</topic><topic>DNA - chemistry</topic><topic>F 2-isoprostanes</topic><topic>F2-Isoprostanes - chemistry</topic><topic>Female</topic><topic>Free radicals</topic><topic>Humans</topic><topic>Hydroxyeicosatetraenoic Acids - chemistry</topic><topic>Levodopa - pharmacology</topic><topic>Lipids - chemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuroprostanes</topic><topic>Oxidative Stress</topic><topic>Oxygen - chemistry</topic><topic>Parkinson disease</topic><topic>Parkinson Disease - blood</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seet, Raymond C.S.</creatorcontrib><creatorcontrib>Lee, Chung-Yung J.</creatorcontrib><creatorcontrib>Lim, Erle C.H.</creatorcontrib><creatorcontrib>Tan, June J.H.</creatorcontrib><creatorcontrib>Quek, Amy M.L.</creatorcontrib><creatorcontrib>Chong, Wan-Ling</creatorcontrib><creatorcontrib>Looi, Woan-Foon</creatorcontrib><creatorcontrib>Huang, Shan-Hong</creatorcontrib><creatorcontrib>Wang, Huansong</creatorcontrib><creatorcontrib>Chan, Yiong-Huak</creatorcontrib><creatorcontrib>Halliwell, Barry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Free radical biology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seet, Raymond C.S.</au><au>Lee, Chung-Yung J.</au><au>Lim, Erle C.H.</au><au>Tan, June J.H.</au><au>Quek, Amy M.L.</au><au>Chong, Wan-Ling</au><au>Looi, Woan-Foon</au><au>Huang, Shan-Hong</au><au>Wang, Huansong</au><au>Chan, Yiong-Huak</au><au>Halliwell, Barry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative damage in Parkinson disease: Measurement using accurate biomarkers</atitle><jtitle>Free radical biology & medicine</jtitle><addtitle>Free Radic Biol Med</addtitle><date>2010-02-15</date><risdate>2010</risdate><volume>48</volume><issue>4</issue><spage>560</spage><epage>566</epage><pages>560-566</pages><issn>0891-5849</issn><eissn>1873-4596</eissn><abstract>Oxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F
2-isoprostanes (F
2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F
4-NPs), phospholipase A
2 (PLA
2) and platelet activating factor–acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F
2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F
4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA
2 and PAF-AH activities were lower, in PD patients compared to controls (
p
<
0.05). The levels of plasma F
2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (
p trend
<
0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (
r
=
−0.305,
p
=
0.023) and plasma total HETEs (
r
=
−0.285,
p
=
0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19969070</pmid><doi>10.1016/j.freeradbiomed.2009.11.026</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 8-Hydroxy-2′-deoxyguanosine Aged Biomarkers - metabolism C-Reactive Protein - chemistry Case-Control Studies Cholesterol - chemistry Disease Progression DNA - chemistry F 2-isoprostanes F2-Isoprostanes - chemistry Female Free radicals Humans Hydroxyeicosatetraenoic Acids - chemistry Levodopa - pharmacology Lipids - chemistry Male Middle Aged Neuroprostanes Oxidative Stress Oxygen - chemistry Parkinson disease Parkinson Disease - blood Parkinson Disease - diagnosis Parkinson Disease - pathology |
| title | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers |
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