Autotaxin Promotes Cancer Invasion via the Lysophosphatidic Acid Receptor 4: Participation of the Cyclic AMP/EPAC/Rac1 Signaling Pathway in Invadopodia Formation

The ability of cancer cells to invade and metastasize is the major cause of death in cancer patients. Autotaxin (ATX) is a secreted lysophospholipase whose level of expression within tumors correlates strongly with their aggressiveness and invasiveness. ATX is the major enzyme involved in the produc...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-06, Vol.70 (11), p.4634-4643
Hauptverfasser:	HARPER, Kelly, ARSENAULT, Dominique, BOULAY-JEAN, Stephanie, LAUZIER, Annie, LUCIEN, Fabrice, DUBOIS, Claire M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Caco-2 Cells Cell Line, Tumor Cyclic AMP - biosynthesis Cyclic AMP - metabolism Female Guanine Nucleotide Exchange Factors - metabolism Humans Medical sciences Mice Mice, Nude Multienzyme Complexes - metabolism Neoplasm Invasiveness Neoplasms - enzymology Neoplasms - metabolism Neoplasms - pathology Pharmacology. Drug treatments Phosphodiesterase I - metabolism Phosphoric Diester Hydrolases Pyrophosphatases - metabolism rac1 GTP-Binding Protein - metabolism Receptors, Purinergic P2 - metabolism Signal Transduction Tumors
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