Analysis of autofeedback mechanisms in the secretion of pro-opiomelanocortin-derived peptides by melanotrope cells of Xenopus laevis
The secretion of most pituitary hormones is under the control of feedback mechanisms. The feedback control of α-melanophore-stimulating hormone (α-MSH) from melanotrope cells is controversial. The possible existence of an autofeedback exerted by α-MSH or other POMC-derived peptides on melanotrope ce...
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| Veröffentlicht in: | General and comparative endocrinology 1992-09, Vol.87 (3), p.394-401 |
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| container_title | General and comparative endocrinology |
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| creator | de Koning, Harry P. Jenks, Bruce G. Scheenen, Wim J.J.M. Balm, Paul H.M. Roubos, Eric W. |
| description | The secretion of most pituitary hormones is under the control of feedback mechanisms. The feedback control of α-melanophore-stimulating hormone (α-MSH) from melanotrope cells is controversial. The possible existence of an autofeedback exerted by α-MSH or other POMC-derived peptides on melanotrope cells of the amphibian
Xenopus laevis has been investigated. α-MSH or its potent agonist 4-norleucine, 7-
d-phenylalanine-α-MSH has no effect on the release of radiolabeled POMC-derived peptides or immunoreactive β-endorphin from superfused neurointermediate pituitary lobes. Melanin concentrating hormone, previously reported to have an α-MSH-like effect on melanophores, did not affect α-MSH secretion. Neurointermediate lobe superfusate, which contains a mixture of POMC-derived peptides, failed to affect the secretory activity of melanotropes. It is concluded that in
X. laevis the secretory activity of melanotropes is not under the control of short-term auto-feedback mechanisms involving α-MSH or other POMC-derived peptides. |
| doi_str_mv | 10.1016/0016-6480(92)90046-M |
| format | Article |
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Xenopus laevis has been investigated. α-MSH or its potent agonist 4-norleucine, 7-
d-phenylalanine-α-MSH has no effect on the release of radiolabeled POMC-derived peptides or immunoreactive β-endorphin from superfused neurointermediate pituitary lobes. Melanin concentrating hormone, previously reported to have an α-MSH-like effect on melanophores, did not affect α-MSH secretion. Neurointermediate lobe superfusate, which contains a mixture of POMC-derived peptides, failed to affect the secretory activity of melanotropes. It is concluded that in
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Xenopus laevis has been investigated. α-MSH or its potent agonist 4-norleucine, 7-
d-phenylalanine-α-MSH has no effect on the release of radiolabeled POMC-derived peptides or immunoreactive β-endorphin from superfused neurointermediate pituitary lobes. Melanin concentrating hormone, previously reported to have an α-MSH-like effect on melanophores, did not affect α-MSH secretion. Neurointermediate lobe superfusate, which contains a mixture of POMC-derived peptides, failed to affect the secretory activity of melanotropes. It is concluded that in
X. laevis the secretory activity of melanotropes is not under the control of short-term auto-feedback mechanisms involving α-MSH or other POMC-derived peptides.</description><subject>alpha-MSH - analogs & derivatives</subject><subject>alpha-MSH - metabolism</subject><subject>alpha-MSH - pharmacology</subject><subject>Animals</subject><subject>beta-Endorphin - metabolism</subject><subject>Cells, Cultured</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Feedback</subject><subject>Iodine Radioisotopes</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - metabolism</subject><subject>Pro-Opiomelanocortin - metabolism</subject><subject>Xenopus laevis</subject><subject>Xenopus laevis - metabolism</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1jAQgIMo6-vqP1DISdZDddK0aXIRlsUv2MWLgreQJlM22iY1SV947_5w2-2iN73MHOaZD-Yh5DmD1wyYeANrqEQj4ULVrxRAI6qbB-TAQLWVkA08JIc_yGPyJOfvANBywc7IGeMcJMgD-XUZzHjKPtM4ULOUOCC63tgfdEJ7a4LPU6Y-0HKLNKNNWHwMGzunWMXZxwlHE6KNqfhQOUz-iI7OOBfvMNP-RHegpDgjtTiOd5u-YYjzkulo8OjzU_JoMGPGZ_f5nHx9_-7L1cfq-vOHT1eX15XlUpZKglCybiUfoLXQyMEIZbBTxiFXwkBtJOe2r1tciYaBAHBusLJr-q53neLn5OU-dz3-54K56Mnn7SYTMC5Zd5yzulPtf0EmuOgUgxVsdtCmmHPCQc_JTyadNAO9WdKbAr0p0KrWd5b0zdr24n7-0k_o_jbtWtb6272O6zeOHpPO1mOw6HxCW7SL_t8LfgOtFqOz</recordid><startdate>19920901</startdate><enddate>19920901</enddate><creator>de Koning, Harry P.</creator><creator>Jenks, Bruce G.</creator><creator>Scheenen, Wim J.J.M.</creator><creator>Balm, Paul H.M.</creator><creator>Roubos, Eric W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920901</creationdate><title>Analysis of autofeedback mechanisms in the secretion of pro-opiomelanocortin-derived peptides by melanotrope cells of Xenopus laevis</title><author>de Koning, Harry P. ; Jenks, Bruce G. ; Scheenen, Wim J.J.M. ; Balm, Paul H.M. ; Roubos, Eric W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-806982583f05c048fa69ae79ade396a02a833cb25e3f0410600ddfc874b7bd793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>alpha-MSH - analogs & derivatives</topic><topic>alpha-MSH - metabolism</topic><topic>alpha-MSH - pharmacology</topic><topic>Animals</topic><topic>beta-Endorphin - metabolism</topic><topic>Cells, Cultured</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Feedback</topic><topic>Iodine Radioisotopes</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - metabolism</topic><topic>Pro-Opiomelanocortin - metabolism</topic><topic>Xenopus laevis</topic><topic>Xenopus laevis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Koning, Harry P.</creatorcontrib><creatorcontrib>Jenks, Bruce G.</creatorcontrib><creatorcontrib>Scheenen, Wim J.J.M.</creatorcontrib><creatorcontrib>Balm, Paul H.M.</creatorcontrib><creatorcontrib>Roubos, Eric W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Koning, Harry P.</au><au>Jenks, Bruce G.</au><au>Scheenen, Wim J.J.M.</au><au>Balm, Paul H.M.</au><au>Roubos, Eric W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of autofeedback mechanisms in the secretion of pro-opiomelanocortin-derived peptides by melanotrope cells of Xenopus laevis</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>1992-09-01</date><risdate>1992</risdate><volume>87</volume><issue>3</issue><spage>394</spage><epage>401</epage><pages>394-401</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>The secretion of most pituitary hormones is under the control of feedback mechanisms. The feedback control of α-melanophore-stimulating hormone (α-MSH) from melanotrope cells is controversial. The possible existence of an autofeedback exerted by α-MSH or other POMC-derived peptides on melanotrope cells of the amphibian
Xenopus laevis has been investigated. α-MSH or its potent agonist 4-norleucine, 7-
d-phenylalanine-α-MSH has no effect on the release of radiolabeled POMC-derived peptides or immunoreactive β-endorphin from superfused neurointermediate pituitary lobes. Melanin concentrating hormone, previously reported to have an α-MSH-like effect on melanophores, did not affect α-MSH secretion. Neurointermediate lobe superfusate, which contains a mixture of POMC-derived peptides, failed to affect the secretory activity of melanotropes. It is concluded that in
X. laevis the secretory activity of melanotropes is not under the control of short-term auto-feedback mechanisms involving α-MSH or other POMC-derived peptides.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1330808</pmid><doi>10.1016/0016-6480(92)90046-M</doi><tpages>8</tpages></addata></record> |
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| ispartof | General and comparative endocrinology, 1992-09, Vol.87 (3), p.394-401 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | alpha-MSH - analogs & derivatives alpha-MSH - metabolism alpha-MSH - pharmacology Animals beta-Endorphin - metabolism Cells, Cultured Chromatography, High Pressure Liquid Feedback Iodine Radioisotopes Pituitary Gland - drug effects Pituitary Gland - metabolism Pro-Opiomelanocortin - metabolism Xenopus laevis Xenopus laevis - metabolism |
| title | Analysis of autofeedback mechanisms in the secretion of pro-opiomelanocortin-derived peptides by melanotrope cells of Xenopus laevis |
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