Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma

Sporadic clear cell renal cell carcinoma (cRCC) is genetically characterized by the recurrent loss of the short arm of chromosome 3, with a hotspot for copy number loss in the 3p21 region. We applied a method called "gene identification by nonsense-mediated mRNA decay inhibition" to a pane...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-06, Vol.70 (11), p.4287-4291
Hauptverfasser:	DUNS, Gerben, VAN DEN BERG, Eva, VAN DUIVENBODE, Inge, OSINGA, Jan, HOLLEMA, Harry, HOFSTRA, Robert M. W, KOK, Klaas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell - enzymology Adenocarcinoma, Clear Cell - genetics Antineoplastic agents Biological and medical sciences Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - genetics Cell Line, Tumor Chromosomes, Human, Pair 3 Comparative Genomic Hybridization DNA Methylation DNA Mutational Analysis Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Histone-Lysine N-Methyltransferase - genetics Humans Kidney Neoplasms - enzymology Kidney Neoplasms - genetics Kidneys Medical sciences Nephrology. Urinary tract diseases Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments RNA, Messenger - genetics RNA, Messenger - metabolism Tumors Tumors of the urinary system
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