Effect of prothrombin time outlier exclusion rules on ISI calibration in multicentre studies

Abstract International Sensitivity Index (ISI) calibration is based on prothrombin time (PT) determinations in fresh plasma samples of healthy (normal) individuals and patients treated with vitamin K-antagonists (VKA). The ISI is calculated from the slope of the orthogonal regression line of the log...

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Veröffentlicht in:	Thrombosis research 2010-06, Vol.125 (6), p.523-528
Hauptverfasser:	van den Besselaar, A.M.H.P, Chantarangkul, V, Tripodi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood and lymphatic vessels Calibration - standards Cardiology. Vascular system Cardiovascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fibrinolytic Agents - therapeutic use Hematology, Oncology and Palliative Medicine Humans International Normalized Ratio Medical sciences Multicenter Studies as Topic - methods Multicenter Studies as Topic - standards Pharmacology. Drug treatments Prothrombin Time - methods Prothrombin Time - standards Regression Analysis Vasodilator agents. Cerebral vasodilators Vitamin K - antagonists & inhibitors World Health Organization
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