Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

Dectin-2 (gene symbol Clec4n) is a C-type lectin expressed by dendritic cells (DCs) and macrophages. However, its functional roles and signaling mechanisms remain to be elucidated. Here, we generated Clec4n −/− mice and showed that this molecule is important for host defense against Candida albicans...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2010-05, Vol.32 (5), p.681-691
Hauptverfasser:	Saijo, Shinobu, Ikeda, Satoshi, Yamabe, Keiko, Kakuta, Shigeru, Ishigame, Harumichi, Akitsu, Aoi, Fujikado, Noriyuki, Kusaka, Toshimasa, Kubo, Sachiko, Chung, Soo-hyun, Komatsu, Ryohei, Miura, Noriko, Adachi, Yoshiyuki, Ohno, Naohito, Shibuya, Kazutoshi, Yamamoto, Natsuo, Kawakami, Kazuyoshi, Yamasaki, Sho, Saito, Takashi, Akira, Shizuo, Iwakura, Yoichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Candida albicans - immunology Candidiasis - immunology Cell Differentiation CELLIMMUNO Cells, Cultured Immunoassay Interleukin-17 - metabolism Interleukin-1beta - immunology Interleukin-23 - immunology Lectins, C-Type - genetics Lectins, C-Type - immunology Male Mannans - immunology Mice Mice, Knockout MOLIMMUNO Signal Transduction SIGNALING T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology
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