A structural classification of substrate-binding proteins
Substrate-binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP-binding cassette transporters for substrate uptake, ion gradient driven transporters, DNA-binding proteins, as well as channels and receptors from both pro- and eukaryotes. A wealth...
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| Veröffentlicht in: | FEBS letters 2010-06, Vol.584 (12), p.2606-2617 |
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| container_title | FEBS letters |
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| creator | Berntsson, Ronnie P.-A. Smits, Sander H.J. Schmitt, Lutz Slotboom, Dirk-Jan Poolman, Bert |
| description | Substrate-binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP-binding cassette transporters for substrate uptake, ion gradient driven transporters, DNA-binding proteins, as well as channels and receptors from both pro- and eukaryotes. A wealth of structural and functional data is available on SBPs, with over 120 unique entries in the Protein Data Bank (PDB). Over a decade ago these proteins were divided into three structural classes, but based on the currently available wealth of structural data, we propose a new classification into six clusters, based on features of their three-dimensional structure. |
| doi_str_mv | 10.1016/j.febslet.2010.04.043 |
| format | Article |
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| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2010-06, Vol.584 (12), p.2606-2617 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Animals ATP-binding cassette transporter Carrier Proteins - chemistry Carrier Proteins - classification Databases, Protein Ligand receptor Membrane Proteins - chemistry Models, Molecular Multiprotein Complexes - chemistry Protein Conformation Signal Transduction Structural classification Substrate-binding protein Tripartite ATP-independent periplasmic transporter |
| title | A structural classification of substrate-binding proteins |
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