3,3′,4,5,5′-pentahydroxy- trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress

Resveratrol exhibits anti-tumor properties against different types of cancer. In this study, several polyhydroxylated resveratrol derivatives were prepared with the aim of discovering new leading compounds with clinical potential for human colon cancer chemotherapy. Among these compounds, 3,3′,4,5,5...

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Veröffentlicht in:	European journal of pharmacology 2010-07, Vol.637 (1), p.55-61
Hauptverfasser:	Li, Haitao, Wu, William Ka Kei, Zheng, Zongping, Che, Chun Tao, Li, Zhi Jie, Xu, Dan Dan, Wong, Clover Ching Man, Ye, Cai Guo, Sung, Joseph Jao Yiu, Cho, Chi Hin, Wang, Mingfu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences Blotting, Western Colon cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cytoplasm - metabolism DNA Fragmentation - drug effects Enzyme-Linked Immunosorbent Assay Gastroenterology. Liver. Pancreas. Abdomen Glutathione - metabolism HT29 Cells Humans Hydroxylated resveratrol derivative Medical sciences Nucleosomes - metabolism Oxidative stress Oxidative Stress - drug effects Pharmacology. Drug treatments Poly(ADP-ribose) Polymerases - metabolism Stilbenes - chemistry Stilbenes - pharmacology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Cells, Cultured Tumors Up-Regulation - drug effects
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