R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in cancer progression, invasion, metastasis, drug resistance, and patient mortality, highlighting Axl as an attractive target for therapeutic development. We have generated and characterized a potent and selective sm...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-02, Vol.70 (4), p.1544-1554
Hauptverfasser:	HOLLAND, Sacha J, PAN, Alison, JING ZHANG, PINGYU DING, APATIRA, Ayodele, CHUA, Joanne, BRANDT, Ralf, PINE, Polly, GOFF, Dane, SINGH, Rajinder, PAYAN, Donald G, HITOSHI, Yasumichi, FRANCI, Christian, YUANMING HU, CHANG, Betty, WEIQUN LI, DUAN, Matt, TORNEROS, Allan, JIAXIN YU, HECKRODT, Thilo J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzocycloheptenes - pharmacology Benzocycloheptenes - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma - drug therapy Carcinoma - mortality Carcinoma - pathology Female Gynecology. Andrology. Obstetrics HeLa Cells Humans K562 Cells Mammary gland diseases Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis Oncogene Proteins - antagonists & inhibitors Pharmacology. Drug treatments Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Survival Analysis Triazoles - pharmacology Triazoles - therapeutic use Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays
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