Antiproliferative Activity of Withanolides against Human Breast Cancer Cell Lines

The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI50 values in the range 0.16−0.71 μM. The aromatic withanoli...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2010-05, Vol.73 (5), p.966-968
Hauptverfasser:	Machin, Rubén P, Veleiro, Adriana S, Nicotra, Viviana E, Oberti, Juan C, M. Padrón, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Breast Neoplasms - pathology Cell Line, Tumor Combinatorial Chemistry Techniques Drug Screening Assays, Antitumor Female General aspects General pharmacology Humans Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Structure-Activity Relationship Withanolides - chemistry Withanolides - pharmacology
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