CD95 promotes tumour growth

CD95/Fas promotes tumour growth CD95, known also as Fas and APO-1, is a classical death receptor that regulates tissue homeostasis through apoptosis. Here it is shown that cancer cells, regardless of their sensitivity to CD95-induced apoptosis, depend for optimal growth on CD95. Without CD95 the inc...

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Veröffentlicht in:	Nature (London) 2010-05, Vol.465 (7297), p.492-496
Hauptverfasser:	Chen, Lina, Park, Sun-Mi, Tumanov, Alexei V., Hau, Annika, Sawada, Kenjiro, Feig, Christine, Turner, Jerrold R., Fu, Yang-Xin, Romero, Iris L., Lengyel, Ernst, Peter, Marcus E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/68 631/337 631/67 Animals Apoptosis Biological and medical sciences Cancer Cancer therapies Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Endometrioid - metabolism Carcinoma, Endometrioid - pathology Cell Line, Tumor Cell Proliferation Development and progression Fas Ligand Protein - antagonists & inhibitors Fas Ligand Protein - immunology Fas Ligand Protein - metabolism fas Receptor - deficiency fas Receptor - genetics fas Receptor - metabolism Female Gene Expression Regulation, Neoplastic General aspects Growth Health aspects Hepatocytes - enzymology Hepatocytes - metabolism Hepatocytes - pathology Humanities and Social Sciences Humans Immune system Influence letter Liver cancer Liver Neoplasms - enzymology Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Medical sciences Mice Mitogen-Activated Protein Kinase 8 - deficiency Mitogen-Activated Protein Kinase 8 - genetics Mitogen-Activated Protein Kinase 8 - metabolism multidisciplinary Neoplasms - metabolism Neoplasms - pathology Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Physiological aspects Science T cells Tumor necrosis factor Tumors
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