Protein tyrosine phosphatase ε inhibits signaling by mitogen-activated protein kinases

Mitogen-activated protein kinases (MAPKs) mediate signaling from the cell membrane to the nucleus following their phosphorylation at conserved threonine and tyrosine residues within their activation loops. We show that protein tyrosine phosphatase epsilon (PTP epsilon) inhibits ERK1 and ERK2 kinase...

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Veröffentlicht in:	Molecular cancer research 2003-05, Vol.1 (7), p.541-550
Hauptverfasser:	TOLEDANO-KATCHALSKI, Hila, KRAUT, Judith, SINES, Tal, GRANOT-ATTAS, Shira, SHOHAT, Galit, GIL-HENN, Hava, YUNG, Yuval, ELSON, Ari
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Cloning, Molecular Fundamental and applied biological sciences. Psychology Humans Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Recombinant Proteins - metabolism Signal Transduction - physiology Transfection
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