Peroxisome Proliferator-activated Receptor Alpha (PPARα) Agonists Induce Constitutive Androstane Receptor (CAR) and Cytochrome P450 2B in Rat Primary Hepatocytes

The constitutive androstane receptor (CAR; NR1I3) is a key transcriptional factor that regulates genes encoding drug-metabolizing enzymes and drug transporters. However, studies on regulation of CAR target genes via up-or down-regulation of CAR are limited. In this study, we examined the effects of...

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Veröffentlicht in:	DRUG METABOLISM AND PHARMACOKINETICS 2010-01, Vol.25 (1), p.108-111
Hauptverfasser:	Saito, Kosuke, Kobayashi, Kaoru, Mizuno, Yuki, Fukuchi, Yukina, Furihata, Tomomi, Chiba, Kan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - biosynthesis Aryl Hydrocarbon Hydroxylases - genetics Cell Culture Techniques Clofibric Acid - analogs & derivatives Clofibric Acid - antagonists & inhibitors Clofibric Acid - pharmacology constitutive androstane receptor (CAR) Cycloheximide - pharmacology Cytochrome P-450 CYP2B1 - biosynthesis Cytochrome P-450 CYP2B1 - genetics cytochrome P450 2B (CYP2B): peroxisome proliferator-activated receptor α (PPARα) Drug Interactions Enzyme Induction - drug effects Enzyme Induction - genetics Fibric Acids Gene Expression Regulation, Enzymologic Hepatocytes - drug effects Hepatocytes - metabolism Male nuclear receptor PPAR alpha - agonists rat primary hepatocytes Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Cytoplasmic and Nuclear - genetics Steroid Hydroxylases - biosynthesis Steroid Hydroxylases - genetics
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