Teasing out the best molecular marker in the AKT/mTOR pathway in head and neck squamous cell cancer patients

Objectives/Hypothesis: No reliable molecular biomarker is currently available for clinical application in the management of head and neck cancer patients. The AKT/mTOR pathway is activated in 90% to 100% of head and neck squamous cell cancer (HNSCC) and could be promising biomarkers closely linked t...

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Veröffentlicht in:	The Laryngoscope 2010-06, Vol.120 (6), p.1159-1165
Hauptverfasser:	Clark, Cheryl, Shah, Shivang, Herman-Ferdinandez, Lilantha, Ekshyyan, Oleksandr, Abreo, Fleurette, Rong, Xiaohua, McLarty, Jerry, Lurie, Aubrey, Milligan, Edward J., Nathan, Cherie-Ann O.
Format:	Artikel
Sprache:	eng
Schlagworte:	4EBP1 Aged Biological and medical sciences Biomarkers, Tumor - metabolism Blotting, Western Carcinoma, Squamous Cell - metabolism Chi-Square Distribution Female Head and Neck Neoplasms - metabolism head and neck squamous cell cancer Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins - metabolism Level of Evidence: 2b Male Medical sciences Middle Aged Mouth Mucosa - metabolism Neoplasm Staging oral mucosa Otorhinolaryngology. Stomatology Phosphorylation Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Retrospective Studies S6 kinase Sensitivity and Specificity Signal Transduction Statistics, Nonparametric TOR Serine-Threonine Kinases
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