Molecular and clinical characteristics of hepatitis B virus in Korea

Korea is an endemic area of hepatitis B virus (HBV) infection but very little is known about the molecular characteristics of HBV isolates from Korean patients or the association with disease progression. The complete HBV genome sequences from 53 Korean patients with chronic hepatitis B, advanced ci...

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Veröffentlicht in:Journal of medical virology 2010-07, Vol.82 (7), p.1126-1134
Hauptverfasser: Ahn, Sang Hoon, Yuen, Lilly, Han, Kwang-Hyub, Littlejohn, Margaret, Chang, Hye Young, Damerow, Hans, Ayres, Anna, Heo, Jeong, Locarnini, Stephen, Revill, Peter A
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container_end_page 1134
container_issue 7
container_start_page 1126
container_title Journal of medical virology
container_volume 82
creator Ahn, Sang Hoon
Yuen, Lilly
Han, Kwang-Hyub
Littlejohn, Margaret
Chang, Hye Young
Damerow, Hans
Ayres, Anna
Heo, Jeong
Locarnini, Stephen
Revill, Peter A
description Korea is an endemic area of hepatitis B virus (HBV) infection but very little is known about the molecular characteristics of HBV isolates from Korean patients or the association with disease progression. The complete HBV genome sequences from 53 Korean patients with chronic hepatitis B, advanced cirrhosis, or hepatocellular carcinoma (HCC) were analyzed to identify (i) subgenotype distribution and genetic diversity and (ii) signature mutations associated with liver disease progression. With the exception of 1 patient infected with HBV/B, all 52 patients (98.1%) were infected with HBV/C, subgenotype C2. These strains were 98.4% identical and the frequency of amino acid substitutions occurring within key immunological epitopes increased with disease severity. A number of amino acid/nucleotide substitutions were associated with HCC, namely sR24K (HBsAg), SI126T (HBsAg), and pcA1846T (precore gene) mutations (P = 0.029, 0.001, and 0.008, respectively). HBV harboring deletions in the pre-S region were also associated with increased liver disease severity (chronic hepatitis B vs. cirrhosis, P = 0.040; chronic hepatitis B vs. HCC, P = 0.040). Despite the high degree of sequence conservation, several key HBV mutations were associated with disease progression. Prospective studies with larger cohorts of patients are required to evaluate further the clinical manifestation of HBV/C2 in Korea. J. Med. Virol. 82: 1126-1134, 2010.
doi_str_mv 10.1002/jmv.21844
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The complete HBV genome sequences from 53 Korean patients with chronic hepatitis B, advanced cirrhosis, or hepatocellular carcinoma (HCC) were analyzed to identify (i) subgenotype distribution and genetic diversity and (ii) signature mutations associated with liver disease progression. With the exception of 1 patient infected with HBV/B, all 52 patients (98.1%) were infected with HBV/C, subgenotype C2. These strains were 98.4% identical and the frequency of amino acid substitutions occurring within key immunological epitopes increased with disease severity. A number of amino acid/nucleotide substitutions were associated with HCC, namely sR24K (HBsAg), SI126T (HBsAg), and pcA1846T (precore gene) mutations (P = 0.029, 0.001, and 0.008, respectively). HBV harboring deletions in the pre-S region were also associated with increased liver disease severity (chronic hepatitis B vs. cirrhosis, P = 0.040; chronic hepatitis B vs. HCC, P = 0.040). 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HBV harboring deletions in the pre-S region were also associated with increased liver disease severity (chronic hepatitis B vs. cirrhosis, P = 0.040; chronic hepatitis B vs. HCC, P = 0.040). Despite the high degree of sequence conservation, several key HBV mutations were associated with disease progression. Prospective studies with larger cohorts of patients are required to evaluate further the clinical manifestation of HBV/C2 in Korea. J. Med. 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subjects Aged
Amino Acid Substitution
Carcinoma, Hepatocellular - pathology
complete genome
Disease Progression
Female
Genome, Viral
genotype
hepatitis B virus
Hepatitis B virus - classification
Hepatitis B virus - genetics
Hepatitis B, Chronic - pathology
Hepatitis B, Chronic - virology
Humans
Korea
Liver Cirrhosis - pathology
Liver Neoplasms - pathology
Male
Middle Aged
Molecular Sequence Data
Phylogeny
Republic of Korea
Young Adult
title Molecular and clinical characteristics of hepatitis B virus in Korea
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