Immunovirological correlates in human rabies treated with therapeutic coma
A 37-year-old woman was admitted to hospital and over the next 5 days developed a progressive encephalitis. Nuchal skin biopsy, analyzed using a Rabies TaqMan© PCR, demonstrated rabies virus RNA. She had a history in keeping with exposure to rabies whilst in South Africa, but had not received pre- o...
Gespeichert in:
| Veröffentlicht in: | Journal of medical virology 2010-07, Vol.82 (7), p.1255-1265 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1265 |
|---|---|
| container_issue | 7 |
| container_start_page | 1255 |
| container_title | Journal of medical virology |
| container_volume | 82 |
| creator | Hunter, M Johnson, N Hedderwick, S McCaughey, C Lowry, K McConville, J Herron, B McQuaid, S Marston, D Goddard, T Harkess, G Goharriz, H Voller, K Solomon, T Willoughby, R.E Fooks, A.R |
| description | A 37-year-old woman was admitted to hospital and over the next 5 days developed a progressive encephalitis. Nuchal skin biopsy, analyzed using a Rabies TaqMan© PCR, demonstrated rabies virus RNA. She had a history in keeping with exposure to rabies whilst in South Africa, but had not received pre- or post-exposure prophylaxis. She was treated with a therapeutic coma according to the "Milwaukee protocol," which failed to prevent the death of the patient. Rabies virus was isolated from CSF and saliva, and rabies antibody was demonstrated in serum (from day 11 onwards) and cerebrospinal fluid (day 13 onwards). She died on day-35 of hospitalization. Autopsy specimens demonstrated the presence of rabies antigen, viral RNA, and viable rabies virus in the central nervous system. J. Med. Virol. 82:1255-1265, 2010. |
| doi_str_mv | 10.1002/jmv.21785 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733112692</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733112692</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4165-9f1f24268755149c31ee4a2cfbee4573c2229d91739292be818e8e6eadf5d7583</originalsourceid><addsrcrecordid>eNp1kE1v1DAQhi0EokvhwB-AXBDikNYzjp34WFVQuixwgNKj5XUmXZd8LHbS0n-Pl2zLidNoRs87M3oYewn8CDjH4-vu5gihrOQjtgCuVa55CY_ZgkOhcqVAHrBnMV5zziuN-JQdIJcguBYLtjzvuqkfbnwY2uHKO9tmbgiBWjtSzHyfbabO9lmwa5_6MVCa19mtHzfZuKFgtzSN3qVMZ5-zJ41tI73Y10N28eH999OP-err2fnpySp3BSiZ6wYaLFBVpZRQaCeAqLDomnWqshQOEXWtoRQaNa6pgooqUmTrRtalrMQhezvv3Ybh10RxNJ2PjtrW9jRM0ZRCAKDSmMh3M-nCEGOgxmyD72y4M8DNzpxJ5sxfc4l9td86rTuqH8h7VQl4swdsTJqaYHvn4z8Oq0IJ3HHHM3frW7r7_0Wz_Pzj_nQ-J3wc6fdDwoafRpWilObyy5kpLj-tlsBXZse_nvnGDsZehfTFxTfk6U2odkpR_AH4QJzU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733112692</pqid></control><display><type>article</type><title>Immunovirological correlates in human rabies treated with therapeutic coma</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Hunter, M ; Johnson, N ; Hedderwick, S ; McCaughey, C ; Lowry, K ; McConville, J ; Herron, B ; McQuaid, S ; Marston, D ; Goddard, T ; Harkess, G ; Goharriz, H ; Voller, K ; Solomon, T ; Willoughby, R.E ; Fooks, A.R</creator><creatorcontrib>Hunter, M ; Johnson, N ; Hedderwick, S ; McCaughey, C ; Lowry, K ; McConville, J ; Herron, B ; McQuaid, S ; Marston, D ; Goddard, T ; Harkess, G ; Goharriz, H ; Voller, K ; Solomon, T ; Willoughby, R.E ; Fooks, A.R</creatorcontrib><description>A 37-year-old woman was admitted to hospital and over the next 5 days developed a progressive encephalitis. Nuchal skin biopsy, analyzed using a Rabies TaqMan© PCR, demonstrated rabies virus RNA. She had a history in keeping with exposure to rabies whilst in South Africa, but had not received pre- or post-exposure prophylaxis. She was treated with a therapeutic coma according to the "Milwaukee protocol," which failed to prevent the death of the patient. Rabies virus was isolated from CSF and saliva, and rabies antibody was demonstrated in serum (from day 11 onwards) and cerebrospinal fluid (day 13 onwards). She died on day-35 of hospitalization. Autopsy specimens demonstrated the presence of rabies antigen, viral RNA, and viable rabies virus in the central nervous system. J. Med. Virol. 82:1255-1265, 2010.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.21785</identifier><identifier>PMID: 20513093</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Antibodies, Viral - blood ; Antibodies, Viral - cerebrospinal fluid ; Antigens, Viral - analysis ; Biological and medical sciences ; Convulsive Therapy ; Fatal Outcome ; Female ; Fundamental and applied biological sciences. Psychology ; human case ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Microbiology ; Milwaukee protocol ; Miscellaneous ; Neutralization Tests ; rabies ; Rabies - blood ; Rabies - diagnosis ; Rabies - therapy ; Rabies - virology ; Rabies virus - genetics ; Rabies virus - immunology ; Rabies virus - isolation & purification ; RNA, Viral - analysis ; Saliva - virology ; South Africa ; therapeutic coma ; Viral diseases ; Virology ; virus</subject><ispartof>Journal of medical virology, 2010-07, Vol.82 (7), p.1255-1265</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4165-9f1f24268755149c31ee4a2cfbee4573c2229d91739292be818e8e6eadf5d7583</citedby><cites>FETCH-LOGICAL-c4165-9f1f24268755149c31ee4a2cfbee4573c2229d91739292be818e8e6eadf5d7583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.21785$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.21785$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22846323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20513093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hunter, M</creatorcontrib><creatorcontrib>Johnson, N</creatorcontrib><creatorcontrib>Hedderwick, S</creatorcontrib><creatorcontrib>McCaughey, C</creatorcontrib><creatorcontrib>Lowry, K</creatorcontrib><creatorcontrib>McConville, J</creatorcontrib><creatorcontrib>Herron, B</creatorcontrib><creatorcontrib>McQuaid, S</creatorcontrib><creatorcontrib>Marston, D</creatorcontrib><creatorcontrib>Goddard, T</creatorcontrib><creatorcontrib>Harkess, G</creatorcontrib><creatorcontrib>Goharriz, H</creatorcontrib><creatorcontrib>Voller, K</creatorcontrib><creatorcontrib>Solomon, T</creatorcontrib><creatorcontrib>Willoughby, R.E</creatorcontrib><creatorcontrib>Fooks, A.R</creatorcontrib><title>Immunovirological correlates in human rabies treated with therapeutic coma</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>A 37-year-old woman was admitted to hospital and over the next 5 days developed a progressive encephalitis. Nuchal skin biopsy, analyzed using a Rabies TaqMan© PCR, demonstrated rabies virus RNA. She had a history in keeping with exposure to rabies whilst in South Africa, but had not received pre- or post-exposure prophylaxis. She was treated with a therapeutic coma according to the "Milwaukee protocol," which failed to prevent the death of the patient. Rabies virus was isolated from CSF and saliva, and rabies antibody was demonstrated in serum (from day 11 onwards) and cerebrospinal fluid (day 13 onwards). She died on day-35 of hospitalization. Autopsy specimens demonstrated the presence of rabies antigen, viral RNA, and viable rabies virus in the central nervous system. J. Med. Virol. 82:1255-1265, 2010.</description><subject>Adult</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - cerebrospinal fluid</subject><subject>Antigens, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Convulsive Therapy</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>human case</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Milwaukee protocol</subject><subject>Miscellaneous</subject><subject>Neutralization Tests</subject><subject>rabies</subject><subject>Rabies - blood</subject><subject>Rabies - diagnosis</subject><subject>Rabies - therapy</subject><subject>Rabies - virology</subject><subject>Rabies virus - genetics</subject><subject>Rabies virus - immunology</subject><subject>Rabies virus - isolation & purification</subject><subject>RNA, Viral - analysis</subject><subject>Saliva - virology</subject><subject>South Africa</subject><subject>therapeutic coma</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>virus</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EokvhwB-AXBDikNYzjp34WFVQuixwgNKj5XUmXZd8LHbS0n-Pl2zLidNoRs87M3oYewn8CDjH4-vu5gihrOQjtgCuVa55CY_ZgkOhcqVAHrBnMV5zziuN-JQdIJcguBYLtjzvuqkfbnwY2uHKO9tmbgiBWjtSzHyfbabO9lmwa5_6MVCa19mtHzfZuKFgtzSN3qVMZ5-zJ41tI73Y10N28eH999OP-err2fnpySp3BSiZ6wYaLFBVpZRQaCeAqLDomnWqshQOEXWtoRQaNa6pgooqUmTrRtalrMQhezvv3Ybh10RxNJ2PjtrW9jRM0ZRCAKDSmMh3M-nCEGOgxmyD72y4M8DNzpxJ5sxfc4l9td86rTuqH8h7VQl4swdsTJqaYHvn4z8Oq0IJ3HHHM3frW7r7_0Wz_Pzj_nQ-J3wc6fdDwoafRpWilObyy5kpLj-tlsBXZse_nvnGDsZehfTFxTfk6U2odkpR_AH4QJzU</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Hunter, M</creator><creator>Johnson, N</creator><creator>Hedderwick, S</creator><creator>McCaughey, C</creator><creator>Lowry, K</creator><creator>McConville, J</creator><creator>Herron, B</creator><creator>McQuaid, S</creator><creator>Marston, D</creator><creator>Goddard, T</creator><creator>Harkess, G</creator><creator>Goharriz, H</creator><creator>Voller, K</creator><creator>Solomon, T</creator><creator>Willoughby, R.E</creator><creator>Fooks, A.R</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201007</creationdate><title>Immunovirological correlates in human rabies treated with therapeutic coma</title><author>Hunter, M ; Johnson, N ; Hedderwick, S ; McCaughey, C ; Lowry, K ; McConville, J ; Herron, B ; McQuaid, S ; Marston, D ; Goddard, T ; Harkess, G ; Goharriz, H ; Voller, K ; Solomon, T ; Willoughby, R.E ; Fooks, A.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4165-9f1f24268755149c31ee4a2cfbee4573c2229d91739292be818e8e6eadf5d7583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - cerebrospinal fluid</topic><topic>Antigens, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Convulsive Therapy</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>human case</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Milwaukee protocol</topic><topic>Miscellaneous</topic><topic>Neutralization Tests</topic><topic>rabies</topic><topic>Rabies - blood</topic><topic>Rabies - diagnosis</topic><topic>Rabies - therapy</topic><topic>Rabies - virology</topic><topic>Rabies virus - genetics</topic><topic>Rabies virus - immunology</topic><topic>Rabies virus - isolation & purification</topic><topic>RNA, Viral - analysis</topic><topic>Saliva - virology</topic><topic>South Africa</topic><topic>therapeutic coma</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>virus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hunter, M</creatorcontrib><creatorcontrib>Johnson, N</creatorcontrib><creatorcontrib>Hedderwick, S</creatorcontrib><creatorcontrib>McCaughey, C</creatorcontrib><creatorcontrib>Lowry, K</creatorcontrib><creatorcontrib>McConville, J</creatorcontrib><creatorcontrib>Herron, B</creatorcontrib><creatorcontrib>McQuaid, S</creatorcontrib><creatorcontrib>Marston, D</creatorcontrib><creatorcontrib>Goddard, T</creatorcontrib><creatorcontrib>Harkess, G</creatorcontrib><creatorcontrib>Goharriz, H</creatorcontrib><creatorcontrib>Voller, K</creatorcontrib><creatorcontrib>Solomon, T</creatorcontrib><creatorcontrib>Willoughby, R.E</creatorcontrib><creatorcontrib>Fooks, A.R</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hunter, M</au><au>Johnson, N</au><au>Hedderwick, S</au><au>McCaughey, C</au><au>Lowry, K</au><au>McConville, J</au><au>Herron, B</au><au>McQuaid, S</au><au>Marston, D</au><au>Goddard, T</au><au>Harkess, G</au><au>Goharriz, H</au><au>Voller, K</au><au>Solomon, T</au><au>Willoughby, R.E</au><au>Fooks, A.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunovirological correlates in human rabies treated with therapeutic coma</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2010-07</date><risdate>2010</risdate><volume>82</volume><issue>7</issue><spage>1255</spage><epage>1265</epage><pages>1255-1265</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>A 37-year-old woman was admitted to hospital and over the next 5 days developed a progressive encephalitis. Nuchal skin biopsy, analyzed using a Rabies TaqMan© PCR, demonstrated rabies virus RNA. She had a history in keeping with exposure to rabies whilst in South Africa, but had not received pre- or post-exposure prophylaxis. She was treated with a therapeutic coma according to the "Milwaukee protocol," which failed to prevent the death of the patient. Rabies virus was isolated from CSF and saliva, and rabies antibody was demonstrated in serum (from day 11 onwards) and cerebrospinal fluid (day 13 onwards). She died on day-35 of hospitalization. Autopsy specimens demonstrated the presence of rabies antigen, viral RNA, and viable rabies virus in the central nervous system. J. Med. Virol. 82:1255-1265, 2010.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20513093</pmid><doi>10.1002/jmv.21785</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-6615 |
| ispartof | Journal of medical virology, 2010-07, Vol.82 (7), p.1255-1265 |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733112692 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Antibodies, Viral - blood Antibodies, Viral - cerebrospinal fluid Antigens, Viral - analysis Biological and medical sciences Convulsive Therapy Fatal Outcome Female Fundamental and applied biological sciences. Psychology human case Human viral diseases Humans Infectious diseases Medical sciences Microbiology Milwaukee protocol Miscellaneous Neutralization Tests rabies Rabies - blood Rabies - diagnosis Rabies - therapy Rabies - virology Rabies virus - genetics Rabies virus - immunology Rabies virus - isolation & purification RNA, Viral - analysis Saliva - virology South Africa therapeutic coma Viral diseases Virology virus |
| title | Immunovirological correlates in human rabies treated with therapeutic coma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T12%3A00%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunovirological%20correlates%20in%20human%20rabies%20treated%20with%20therapeutic%20coma&rft.jtitle=Journal%20of%20medical%20virology&rft.au=Hunter,%20M&rft.date=2010-07&rft.volume=82&rft.issue=7&rft.spage=1255&rft.epage=1265&rft.pages=1255-1265&rft.issn=0146-6615&rft.eissn=1096-9071&rft.coden=JMVIDB&rft_id=info:doi/10.1002/jmv.21785&rft_dat=%3Cproquest_cross%3E733112692%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733112692&rft_id=info:pmid/20513093&rfr_iscdi=true |