Dystrophin-like immunoreactivity in monkey and human brain areas involved in learning and motor functions
Two antidystrophin antibodies against different fragments of dystrophin were used to detect this polypeptide in monkey and human brains. Dystrophin was revealed by immunoperoxidase amplified with the biotin/avidin system and by immunoblotting. A dystrophin-like immunoreactivity was uniformly express...
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| Veröffentlicht in: | Neuroscience letters 1992-07, Vol.141 (2), p.181-186 |
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| container_title | Neuroscience letters |
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| creator | Huard, Johnny Côté, Pierre-Yves Parent, André Bouchard, Jean-Pierre Tremblay, Jacques P. |
| description | Two antidystrophin antibodies against different fragments of dystrophin were used to detect this polypeptide in monkey and human brains. Dystrophin was revealed by immunoperoxidase amplified with the biotin/avidin system and by immunoblotting. A dystrophin-like immunoreactivity was uniformly expressed in several brain regions implicated in learning and motor functions. Dystrophin function is not clear but our results raise the possibility that this protein may be involved in the cognitive impairment observed in several Duchenne muscular dystrophy (DMD) patients. |
| doi_str_mv | 10.1016/0304-3940(92)90890-J |
| format | Article |
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Dystrophin was revealed by immunoperoxidase amplified with the biotin/avidin system and by immunoblotting. A dystrophin-like immunoreactivity was uniformly expressed in several brain regions implicated in learning and motor functions. Dystrophin function is not clear but our results raise the possibility that this protein may be involved in the cognitive impairment observed in several Duchenne muscular dystrophy (DMD) patients.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(92)90890-J</identifier><identifier>PMID: 1279470</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Brain - metabolism ; Brain - physiology ; Central nervous system ; Diseases of striated muscles. 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Dystrophin was revealed by immunoperoxidase amplified with the biotin/avidin system and by immunoblotting. A dystrophin-like immunoreactivity was uniformly expressed in several brain regions implicated in learning and motor functions. Dystrophin function is not clear but our results raise the possibility that this protein may be involved in the cognitive impairment observed in several Duchenne muscular dystrophy (DMD) patients.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - physiology</subject><subject>Central nervous system</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Dystrophin</subject><subject>Dystrophin - metabolism</subject><subject>Dystrophin-like protein</subject><subject>Human</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Learning - physiology</subject><subject>Medical sciences</subject><subject>Monkey</subject><subject>Motor Activity - physiology</subject><subject>Neurology</subject><subject>Saimiri - metabolism</subject><subject>Saimiri sciureus</subject><subject>Staining and Labeling</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2LFDEQxYMo67j6Hyj0QUQPral0upNcFmT9XBa86Dnko9qN252MSffA_Pdmdob1pqeCer96FO8R8hzoW6AwvKMd5W2nOH2t2BtFpaLt1QOyASlYK5RgD8nmHnlMnpTyi1LaQ8_PyBkwobigGxI-7MuS0_YmxHYKt9iEeV5jymjcEnZh2TchNnOKt7hvTPTNzTqb2Nhs6tpUqlR9l6Yd-gM4ockxxJ936JyWlJtxjdUpxfKUPBrNVPDZaZ6TH58-fr_80l5_-_z18v116ziIpQVjrZeds56N0kneq37kqmMDCO-ZRQsSZA9O9QKts8IORkjqqBRgOFXQnZNXR99tTr9XLIueQ3E4TSZiWosWXQfA2PBfEAbWS8p5BfkRdDmVknHU2xxmk_caqD5UoQ8560POWjF9V4W-qmcvTv6rndH_PTpmX_WXJ90UZ6Yxm-hCucf6TsDAZcUujhjW0HYBsy4uYHToQ0a3aJ_Cv__4AwKcplE</recordid><startdate>19920720</startdate><enddate>19920720</enddate><creator>Huard, Johnny</creator><creator>Côté, Pierre-Yves</creator><creator>Parent, André</creator><creator>Bouchard, Jean-Pierre</creator><creator>Tremblay, Jacques P.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920720</creationdate><title>Dystrophin-like immunoreactivity in monkey and human brain areas involved in learning and motor functions</title><author>Huard, Johnny ; Côté, Pierre-Yves ; Parent, André ; Bouchard, Jean-Pierre ; Tremblay, Jacques P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1abbd83cbd2f8c84595f4932617dd2beb181851c957ebcb7b6a780c0871a40913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - physiology</topic><topic>Central nervous system</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Dystrophin</topic><topic>Dystrophin - metabolism</topic><topic>Dystrophin-like protein</topic><topic>Human</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Learning - physiology</topic><topic>Medical sciences</topic><topic>Monkey</topic><topic>Motor Activity - physiology</topic><topic>Neurology</topic><topic>Saimiri - metabolism</topic><topic>Saimiri sciureus</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huard, Johnny</creatorcontrib><creatorcontrib>Côté, Pierre-Yves</creatorcontrib><creatorcontrib>Parent, André</creatorcontrib><creatorcontrib>Bouchard, Jean-Pierre</creatorcontrib><creatorcontrib>Tremblay, Jacques P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huard, Johnny</au><au>Côté, Pierre-Yves</au><au>Parent, André</au><au>Bouchard, Jean-Pierre</au><au>Tremblay, Jacques P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dystrophin-like immunoreactivity in monkey and human brain areas involved in learning and motor functions</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1992-07-20</date><risdate>1992</risdate><volume>141</volume><issue>2</issue><spage>181</spage><epage>186</epage><pages>181-186</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Two antidystrophin antibodies against different fragments of dystrophin were used to detect this polypeptide in monkey and human brains. Dystrophin was revealed by immunoperoxidase amplified with the biotin/avidin system and by immunoblotting. A dystrophin-like immunoreactivity was uniformly expressed in several brain regions implicated in learning and motor functions. Dystrophin function is not clear but our results raise the possibility that this protein may be involved in the cognitive impairment observed in several Duchenne muscular dystrophy (DMD) patients.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1279470</pmid><doi>10.1016/0304-3940(92)90890-J</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1992-07, Vol.141 (2), p.181-186 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Biological and medical sciences Brain - metabolism Brain - physiology Central nervous system Diseases of striated muscles. Neuromuscular diseases Dystrophin Dystrophin - metabolism Dystrophin-like protein Human Humans Immunoblotting Immunohistochemistry Learning - physiology Medical sciences Monkey Motor Activity - physiology Neurology Saimiri - metabolism Saimiri sciureus Staining and Labeling |
| title | Dystrophin-like immunoreactivity in monkey and human brain areas involved in learning and motor functions |
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