Dazl Promotes Germ Cell Differentiation from Embryonic Stem Cells

It has been demonstrated that through the formation of embryoid bodies (EBs) germ cells can be derived from embryonic stem (ES) cells. Here, we describe a transgene expression approach to derive germ cells directly from ES cells in vitro without EB formation. Through the ectopic expression of Delete...

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Veröffentlicht in:	Journal of molecular cell biology 2009-12, Vol.1 (2), p.93-103
Hauptverfasser:	Yu, Zhuo, Ji, Ping, Cao, Jinping, Zhu, Shu, Li, Yao, Zheng, Lin, Chen, Xuejin, Feng, Lixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Cell Differentiation Cells, Cultured Embryo, Mammalian - cytology Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Female Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Male Mice Nanog Homeobox Protein Oocytes - cytology Oocytes - metabolism Ovarian Follicle - cytology Ovarian Follicle - embryology Ovarian Follicle - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Seminiferous Tubules - cytology Seminiferous Tubules - embryology Seminiferous Tubules - metabolism Sperm Injections, Intracytoplasmic Sperm Motility - physiology Sperm Tail - metabolism Spermatozoa - cytology Spermatozoa - metabolism Time Factors Transfection
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