Combination Therapy of Interleukin-2 and Sorafenib Improves Survival Benefits and Prevents Spontaneous Pulmonary Metastasis in Murine Renal Cell Carcinoma Models

Objective The objective of this study was to evaluate the benefits of combination therapy consisting of recombinant human interleukin-2 and sorafenib for survival efficacy and the suppression of metastasis in murine renal cell carcinoma models. Methods Lung-metastasized renal cell carcinoma mice wer...

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Veröffentlicht in:	Japanese journal of clinical oncology 2010-06, Vol.40 (6), p.503-507
Hauptverfasser:	Amagai, Yosuke, Matsumoto, Mitsunobu, Hojo, Kanji, Iguchi, Motofumi, Wada, Tooru, Tanaka, Hidekazu, Ide, Nobuyuki, Kato, Akira, Shichijo, Michitaka, Abe, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Benzenesulfonates - administration & dosage Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - secondary Carcinoma, Renal Cell - surgery Cell Line, Tumor combination therapy Female IL-2 Interleukin-2 - administration & dosage Kidney Neoplasms - drug therapy Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - surgery Lung Neoplasms - mortality Lung Neoplasms - prevention & control Lung Neoplasms - secondary Mice Mice, Inbred BALB C Nephrectomy Niacinamide - analogs & derivatives Phenylurea Compounds pulmonary metastasis Pyridines - administration & dosage Recombinant Proteins - administration & dosage renal cell carcinoma sorafenib Survival Rate
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