Cytotoxic Effects of Tanshinones from Salvia miltiorrhiza on Doxorubicin-Resistant Human Liver Cancer Cells

P-Glycoprotein (Pgp) overexpression and alterations in p53 oncogene expression are known to affect chemotherapeutic efficacy in the treatment of human hepatocellular carcinoma (HCC). The present study has demonstrated the anti-HCC potential of cryptotanshinone (1), dihydrotanshinone (2), tanshinone...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2010-05, Vol.73 (5), p.854-859
Hauptverfasser:	Lee, Wayne Y. W, Cheung, Chartia C. M, Liu, Ken W. K, Fung, K. P, Wong, John, Lai, Paul B. S, Yeung, John H. K
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Diterpenes, Abietane Doxorubicin - pharmacology Drug Resistance, Neoplasm - drug effects General pharmacology Humans Medical sciences Models, Biological Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenanthrenes - chemistry Phenanthrenes - isolation & purification Phenanthrenes - pharmacology Plants, Medicinal - chemistry Salvia miltiorrhiza - chemistry
Online-Zugang:	Volltext
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