First-trimester placental growth factor as a marker for hypertensive disorders and SGA
Objective The objective of this study was to examine first‐trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications. Methods In this case–control study, PlGF levels were measured by AutoDELFIA immunoassay platform. There...
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| Veröffentlicht in: | Prenatal diagnosis 2010-06, Vol.30 (6), p.565-570 |
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| creator | Cowans, N. J. Stamatopoulou, A. Matwejew, E. von Kaisenberg, C. S. Spencer, K. |
| description | Objective
The objective of this study was to examine first‐trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications.
Methods
In this case–control study, PlGF levels were measured by AutoDELFIA immunoassay platform. There were 47 cases of at least one of the following adverse outcomes: pre‐eclampsia (PE), small for gestational age (SGA), haemolysis elevated liver enzymes and low platelets (HELLP) and gestational hypertension (GH) and 452 matched controls.
Results
PlGF levels were significantly lower in cases of all PE, early PE, HELLP, all SGA, early SGA and SGA without PE, but not in GH, late PE, late SGA, PE with SGA or PE without SGA or HELLP.
Conclusion
Low levels of first‐trimester PlGF provide a good indicator of SGA complications and some hypertensive disorders, in particular severe cases of PE such as early onset and HELLP syndrome. Copyright © 2010 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/pd.2525 |
| format | Article |
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The objective of this study was to examine first‐trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications.
Methods
In this case–control study, PlGF levels were measured by AutoDELFIA immunoassay platform. There were 47 cases of at least one of the following adverse outcomes: pre‐eclampsia (PE), small for gestational age (SGA), haemolysis elevated liver enzymes and low platelets (HELLP) and gestational hypertension (GH) and 452 matched controls.
Results
PlGF levels were significantly lower in cases of all PE, early PE, HELLP, all SGA, early SGA and SGA without PE, but not in GH, late PE, late SGA, PE with SGA or PE without SGA or HELLP.
Conclusion
Low levels of first‐trimester PlGF provide a good indicator of SGA complications and some hypertensive disorders, in particular severe cases of PE such as early onset and HELLP syndrome. Copyright © 2010 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.2525</identifier><identifier>PMID: 20509158</identifier><identifier>CODEN: PRDIDM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; adverse outcome ; Biological and medical sciences ; Biomarkers - analysis ; Biomarkers - blood ; Case-Control Studies ; Delivery. Postpartum. Lactation ; Female ; Fetal Growth Retardation - blood ; Fetal Growth Retardation - diagnosis ; first trimester ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Gestational Age ; Gynecology. Andrology. Obstetrics ; HELLP ; Humans ; Hypertension, Pregnancy-Induced - blood ; Hypertension, Pregnancy-Induced - diagnosis ; Infant, Newborn ; Infant, Small for Gestational Age - blood ; Medical sciences ; Models, Biological ; Molecular and cellular biology ; Placenta Growth Factor ; pre-eclampsia ; Pregnancy ; Pregnancy Outcome ; Pregnancy Proteins - analysis ; Pregnancy Proteins - blood ; Pregnancy Trimester, First - blood ; Prenatal Diagnosis - methods ; Prognosis ; screening ; SGA</subject><ispartof>Prenatal diagnosis, 2010-06, Vol.30 (6), p.565-570</ispartof><rights>Copyright © 2010 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3845-f0e33963ff41be01ee3020243b9809c212915859ac91d21568d93cc98b1af3653</citedby><cites>FETCH-LOGICAL-c3845-f0e33963ff41be01ee3020243b9809c212915859ac91d21568d93cc98b1af3653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.2525$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.2525$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22811494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20509158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cowans, N. J.</creatorcontrib><creatorcontrib>Stamatopoulou, A.</creatorcontrib><creatorcontrib>Matwejew, E.</creatorcontrib><creatorcontrib>von Kaisenberg, C. S.</creatorcontrib><creatorcontrib>Spencer, K.</creatorcontrib><title>First-trimester placental growth factor as a marker for hypertensive disorders and SGA</title><title>Prenatal diagnosis</title><addtitle>Prenat. Diagn</addtitle><description>Objective
The objective of this study was to examine first‐trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications.
Methods
In this case–control study, PlGF levels were measured by AutoDELFIA immunoassay platform. There were 47 cases of at least one of the following adverse outcomes: pre‐eclampsia (PE), small for gestational age (SGA), haemolysis elevated liver enzymes and low platelets (HELLP) and gestational hypertension (GH) and 452 matched controls.
Results
PlGF levels were significantly lower in cases of all PE, early PE, HELLP, all SGA, early SGA and SGA without PE, but not in GH, late PE, late SGA, PE with SGA or PE without SGA or HELLP.
Conclusion
Low levels of first‐trimester PlGF provide a good indicator of SGA complications and some hypertensive disorders, in particular severe cases of PE such as early onset and HELLP syndrome. Copyright © 2010 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>adverse outcome</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Female</subject><subject>Fetal Growth Retardation - blood</subject><subject>Fetal Growth Retardation - diagnosis</subject><subject>first trimester</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>HELLP</subject><subject>Humans</subject><subject>Hypertension, Pregnancy-Induced - blood</subject><subject>Hypertension, Pregnancy-Induced - diagnosis</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age - blood</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Molecular and cellular biology</subject><subject>Placenta Growth Factor</subject><subject>pre-eclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Proteins - analysis</subject><subject>Pregnancy Proteins - blood</subject><subject>Pregnancy Trimester, First - blood</subject><subject>Prenatal Diagnosis - methods</subject><subject>Prognosis</subject><subject>screening</subject><subject>SGA</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1PAyEQBmBiNFqr8R-YvRgPZiswSxeOxo-qMWri15FQdtDV7e4KW7X_XppWPXkCkiczzDuE7DA6YJTyw7YYcMHFCukxqvKUcg6rpEdZvIMUbINshvAaoeQqXycbnAqqmJA98nhW-tClnS8nGDr0SVsZi3VnquTZN5_dS-KM7RqfmJCYZGL8WzQuvl9mLfoO61B-YFKUofEF-mjqIrkbHW2RNWeqgNvLs08ezk7vj8_Tq5vRxfHRVWpBZiJ1FAHUEJzL2BgpQwTKKc9grCRVljM-_6VQxipWcCaGslBgrZJjZhwMBfTJ_qJu65v3aZxAT8pgsapMjc006BwgBiIk_EnrmxA8Ot3GmY2faUb1PEPdFnqeYZS7y5rT8QSLX_cTWgR7S2CCNZXzprZl-HNcMpapLLqDhfssK5z910_fnizbpgtdxj18_eqYuB7mkAv9dD3Sit3m15dPJxrgG1QrlEw</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Cowans, N. J.</creator><creator>Stamatopoulou, A.</creator><creator>Matwejew, E.</creator><creator>von Kaisenberg, C. S.</creator><creator>Spencer, K.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201006</creationdate><title>First-trimester placental growth factor as a marker for hypertensive disorders and SGA</title><author>Cowans, N. J. ; Stamatopoulou, A. ; Matwejew, E. ; von Kaisenberg, C. S. ; Spencer, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3845-f0e33963ff41be01ee3020243b9809c212915859ac91d21568d93cc98b1af3653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>adverse outcome</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Female</topic><topic>Fetal Growth Retardation - blood</topic><topic>Fetal Growth Retardation - diagnosis</topic><topic>first trimester</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>HELLP</topic><topic>Humans</topic><topic>Hypertension, Pregnancy-Induced - blood</topic><topic>Hypertension, Pregnancy-Induced - diagnosis</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age - blood</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Molecular and cellular biology</topic><topic>Placenta Growth Factor</topic><topic>pre-eclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Proteins - analysis</topic><topic>Pregnancy Proteins - blood</topic><topic>Pregnancy Trimester, First - blood</topic><topic>Prenatal Diagnosis - methods</topic><topic>Prognosis</topic><topic>screening</topic><topic>SGA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cowans, N. J.</creatorcontrib><creatorcontrib>Stamatopoulou, A.</creatorcontrib><creatorcontrib>Matwejew, E.</creatorcontrib><creatorcontrib>von Kaisenberg, C. S.</creatorcontrib><creatorcontrib>Spencer, K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cowans, N. J.</au><au>Stamatopoulou, A.</au><au>Matwejew, E.</au><au>von Kaisenberg, C. S.</au><au>Spencer, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First-trimester placental growth factor as a marker for hypertensive disorders and SGA</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat. Diagn</addtitle><date>2010-06</date><risdate>2010</risdate><volume>30</volume><issue>6</issue><spage>565</spage><epage>570</epage><pages>565-570</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><coden>PRDIDM</coden><abstract>Objective
The objective of this study was to examine first‐trimester maternal serum placental growth factor (PlGF) levels in pregnancies which later develop hypertensive and growth complications.
Methods
In this case–control study, PlGF levels were measured by AutoDELFIA immunoassay platform. There were 47 cases of at least one of the following adverse outcomes: pre‐eclampsia (PE), small for gestational age (SGA), haemolysis elevated liver enzymes and low platelets (HELLP) and gestational hypertension (GH) and 452 matched controls.
Results
PlGF levels were significantly lower in cases of all PE, early PE, HELLP, all SGA, early SGA and SGA without PE, but not in GH, late PE, late SGA, PE with SGA or PE without SGA or HELLP.
Conclusion
Low levels of first‐trimester PlGF provide a good indicator of SGA complications and some hypertensive disorders, in particular severe cases of PE such as early onset and HELLP syndrome. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>20509158</pmid><doi>10.1002/pd.2525</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult adverse outcome Biological and medical sciences Biomarkers - analysis Biomarkers - blood Case-Control Studies Delivery. Postpartum. Lactation Female Fetal Growth Retardation - blood Fetal Growth Retardation - diagnosis first trimester Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Gestational Age Gynecology. Andrology. Obstetrics HELLP Humans Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - diagnosis Infant, Newborn Infant, Small for Gestational Age - blood Medical sciences Models, Biological Molecular and cellular biology Placenta Growth Factor pre-eclampsia Pregnancy Pregnancy Outcome Pregnancy Proteins - analysis Pregnancy Proteins - blood Pregnancy Trimester, First - blood Prenatal Diagnosis - methods Prognosis screening SGA |
| title | First-trimester placental growth factor as a marker for hypertensive disorders and SGA |
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