Bilirubin, a Physiological Antioxidant, Can Improve Cryopreservation of Human Hepatocytes

ABSTRACT The availability of cryopreserved hepatocytes is required for a more widespread use of hepatocyte transplantation, but human hepatocytes are easily damaged during freezing‐thawing. Here, preincubation with unconjugated bilirubin, a physiological antioxidant, resulted in increased viability...

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Veröffentlicht in:	Journal of pediatric gastroenterology and nutrition 2010-06, Vol.50 (6), p.691-693
Hauptverfasser:	Galbiati, G, Muraca, M, Mitry, RR, Hughes, RD, Lehec, SC, Puppi, J, Sagias, FG, Caruso, M, Mieli‐Vergani, G, Dhawan, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology bilirubin Bilirubin - pharmacology Biological and medical sciences Cell Survival - drug effects Cryopreservation - methods Cryoprotective Agents - pharmacology Feeding. Feeding behavior freeze‐thaw Freezing Fundamental and applied biological sciences. Psychology hepatocyte transplantation Hepatocytes - drug effects Humans liver metabolism Organ Preservation - methods Vertebrates: anatomy and physiology, studies on body, several organs or systems
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