A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro
BACKGROUND Prostate cancer is the most common solid‐tumor cancer in US males but is rare in Asian males. When Asian men adopt the US lifestyle, clinical prostate cancer increases greatly. Epidemiological data from men in the US indicate that regular activity may reduce the risk for prostate cancer....
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| Veröffentlicht in: | The Prostate 2003-08, Vol.56 (3), p.201-206 |
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| container_title | The Prostate |
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| creator | Barnard, R. James Ngo, Tung H. Leung, Pak-Shan Aronson, William J. Golding, Lawrence A. |
| description | BACKGROUND
Prostate cancer is the most common solid‐tumor cancer in US males but is rare in Asian males. When Asian men adopt the US lifestyle, clinical prostate cancer increases greatly. Epidemiological data from men in the US indicate that regular activity may reduce the risk for prostate cancer.
METHODS
Serum was obtained from three groups of similar‐aged men, Control, Diet and Exercise, and Exercise alone were used to stimulate LNCaP cells in culture. Growth and apoptosis of tumor cells were measured. Serum samples were also used to measure insulin, IGF‐1, IGFBP‐1.
RESULTS
The Diet and Exercise and the Exercise alone groups had lower serum insulin and IGF‐1 but higher IGFBP‐1 compared to Controls. LNCaP cell growth was reduced in both groups compared to Control and there was a major increase in apoptosis of tumor cells.
CONCLUSIONS
A low‐fat diet and/or intensive exercise results in change in serum hormones and growth factors in vivo that can reduce growth and induce apoptosis of LNCaP prostate tumor cells in vitro. Prostate 56: 201–206, 2003. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pros.10251 |
| format | Article |
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Prostate cancer is the most common solid‐tumor cancer in US males but is rare in Asian males. When Asian men adopt the US lifestyle, clinical prostate cancer increases greatly. Epidemiological data from men in the US indicate that regular activity may reduce the risk for prostate cancer.
METHODS
Serum was obtained from three groups of similar‐aged men, Control, Diet and Exercise, and Exercise alone were used to stimulate LNCaP cells in culture. Growth and apoptosis of tumor cells were measured. Serum samples were also used to measure insulin, IGF‐1, IGFBP‐1.
RESULTS
The Diet and Exercise and the Exercise alone groups had lower serum insulin and IGF‐1 but higher IGFBP‐1 compared to Controls. LNCaP cell growth was reduced in both groups compared to Control and there was a major increase in apoptosis of tumor cells.
CONCLUSIONS
A low‐fat diet and/or intensive exercise results in change in serum hormones and growth factors in vivo that can reduce growth and induce apoptosis of LNCaP prostate tumor cells in vitro. Prostate 56: 201–206, 2003. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.10251</identifier><identifier>PMID: 12772189</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Apoptosis ; Biological and medical sciences ; Cell Division ; Diet, Fat-Restricted ; Exercise ; Humans ; Hypoglycemic Agents - blood ; IGF-1 ; IGFBP-1 ; insulin ; Insulin - blood ; Insulin-Like Growth Factor Binding Protein 1 - blood ; Insulin-Like Growth Factor I - analysis ; Life Style ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Prostatic Neoplasms - diet therapy ; Prostatic Neoplasms - physiopathology ; Risk Factors ; Tumor Cells, Cultured ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>The Prostate, 2003-08, Vol.56 (3), p.201-206</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4591-bd54cb725e2f452a1f81ab29e57c7433b1b636a98fafac2a3b48ff9754af5a253</citedby><cites>FETCH-LOGICAL-c4591-bd54cb725e2f452a1f81ab29e57c7433b1b636a98fafac2a3b48ff9754af5a253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.10251$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.10251$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15027699$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12772189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barnard, R. James</creatorcontrib><creatorcontrib>Ngo, Tung H.</creatorcontrib><creatorcontrib>Leung, Pak-Shan</creatorcontrib><creatorcontrib>Aronson, William J.</creatorcontrib><creatorcontrib>Golding, Lawrence A.</creatorcontrib><title>A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>BACKGROUND
Prostate cancer is the most common solid‐tumor cancer in US males but is rare in Asian males. When Asian men adopt the US lifestyle, clinical prostate cancer increases greatly. Epidemiological data from men in the US indicate that regular activity may reduce the risk for prostate cancer.
METHODS
Serum was obtained from three groups of similar‐aged men, Control, Diet and Exercise, and Exercise alone were used to stimulate LNCaP cells in culture. Growth and apoptosis of tumor cells were measured. Serum samples were also used to measure insulin, IGF‐1, IGFBP‐1.
RESULTS
The Diet and Exercise and the Exercise alone groups had lower serum insulin and IGF‐1 but higher IGFBP‐1 compared to Controls. LNCaP cell growth was reduced in both groups compared to Control and there was a major increase in apoptosis of tumor cells.
CONCLUSIONS
A low‐fat diet and/or intensive exercise results in change in serum hormones and growth factors in vivo that can reduce growth and induce apoptosis of LNCaP prostate tumor cells in vitro. Prostate 56: 201–206, 2003. © 2003 Wiley‐Liss, Inc.</description><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Diet, Fat-Restricted</subject><subject>Exercise</subject><subject>Humans</subject><subject>Hypoglycemic Agents - blood</subject><subject>IGF-1</subject><subject>IGFBP-1</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>Insulin-Like Growth Factor Binding Protein 1 - blood</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostatic Neoplasms - diet therapy</subject><subject>Prostatic Neoplasms - physiopathology</subject><subject>Risk Factors</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EokvhwgdAvsABKdR_4-RYFbpUWlFEQRytSTKmhmzS2k53--1xyEJvnOzD771584aQl5y944yJk5swxvwTmj8iK85qUzCm9GOyYsKwQnFpjsizGH8ylnEmnpIjLowRvKpXJJ3SftwVDhLtPCYKQ3cyBhpTwGEap0hxj6H1ESn0CUOk6Rrpxfqcwt5H6gd65-_GWUUDdlOLkc5pEiSkadpmpxb7nv4I4y5dL3gK43PyxEEf8cXhPSbfzj98PftYbC7XF2enm6JVuuZF02nVNkZoFE5pAdxVHBpRozatUVI2vCllCXXlwEErQDaqcq42WoHTILQ8Jm8W35zpdsKY7NbHORAMmHezRkrOytJk8O0Ctjl8DOjsTfBbCPeWMzt3bOet7J-OM_zq4Do1W-we0EOpGXh9ACC20LsAQ27wgdP5LmU9c3zhdr7H-_-MtJ-_XF79HV4sGh8T7v9pIPyyeQ-j7fdPa2uEqt7rzZWt5W9v9qP8</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Barnard, R. James</creator><creator>Ngo, Tung H.</creator><creator>Leung, Pak-Shan</creator><creator>Aronson, William J.</creator><creator>Golding, Lawrence A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro</title><author>Barnard, R. James ; Ngo, Tung H. ; Leung, Pak-Shan ; Aronson, William J. ; Golding, Lawrence A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4591-bd54cb725e2f452a1f81ab29e57c7433b1b636a98fafac2a3b48ff9754af5a253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Diet, Fat-Restricted</topic><topic>Exercise</topic><topic>Humans</topic><topic>Hypoglycemic Agents - blood</topic><topic>IGF-1</topic><topic>IGFBP-1</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>Insulin-Like Growth Factor Binding Protein 1 - blood</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prostatic Neoplasms - diet therapy</topic><topic>Prostatic Neoplasms - physiopathology</topic><topic>Risk Factors</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barnard, R. James</creatorcontrib><creatorcontrib>Ngo, Tung H.</creatorcontrib><creatorcontrib>Leung, Pak-Shan</creatorcontrib><creatorcontrib>Aronson, William J.</creatorcontrib><creatorcontrib>Golding, Lawrence A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barnard, R. James</au><au>Ngo, Tung H.</au><au>Leung, Pak-Shan</au><au>Aronson, William J.</au><au>Golding, Lawrence A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>56</volume><issue>3</issue><spage>201</spage><epage>206</epage><pages>201-206</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>BACKGROUND
Prostate cancer is the most common solid‐tumor cancer in US males but is rare in Asian males. When Asian men adopt the US lifestyle, clinical prostate cancer increases greatly. Epidemiological data from men in the US indicate that regular activity may reduce the risk for prostate cancer.
METHODS
Serum was obtained from three groups of similar‐aged men, Control, Diet and Exercise, and Exercise alone were used to stimulate LNCaP cells in culture. Growth and apoptosis of tumor cells were measured. Serum samples were also used to measure insulin, IGF‐1, IGFBP‐1.
RESULTS
The Diet and Exercise and the Exercise alone groups had lower serum insulin and IGF‐1 but higher IGFBP‐1 compared to Controls. LNCaP cell growth was reduced in both groups compared to Control and there was a major increase in apoptosis of tumor cells.
CONCLUSIONS
A low‐fat diet and/or intensive exercise results in change in serum hormones and growth factors in vivo that can reduce growth and induce apoptosis of LNCaP prostate tumor cells in vitro. Prostate 56: 201–206, 2003. © 2003 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12772189</pmid><doi>10.1002/pros.10251</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Prostate, 2003-08, Vol.56 (3), p.201-206 |
| issn | 0270-4137 1097-0045 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Apoptosis Biological and medical sciences Cell Division Diet, Fat-Restricted Exercise Humans Hypoglycemic Agents - blood IGF-1 IGFBP-1 insulin Insulin - blood Insulin-Like Growth Factor Binding Protein 1 - blood Insulin-Like Growth Factor I - analysis Life Style Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Prostatic Neoplasms - diet therapy Prostatic Neoplasms - physiopathology Risk Factors Tumor Cells, Cultured Tumors of the urinary system Urinary tract. Prostate gland |
| title | A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro |
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