Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity
The aim of this study was to examine the effect of surgical weight reduction on cardiac structure and function and to seek the determinants of these changes. Sixty-six severely obese adults (BMI ≥35 kg/m2) who received bariatric surgery underwent echocardiographic examination before and 3 months aft...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2010-06, Vol.18 (6), p.1188-1193 |
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| creator | Hsuan, Chin-Feng Huang, Chih-Kun Lin, Jou-Wei Lin, Lung-Chun Lee, Thung-Lip Tai, Chi-Ming Yin, Wei-Hsian Tseng, Wei-Kung Hsu, Kwan-Lih Wu, Chau-Chung |
| description | The aim of this study was to examine the effect of surgical weight reduction on cardiac structure and function and to seek the determinants of these changes. Sixty-six severely obese adults (BMI ≥35 kg/m2) who received bariatric surgery underwent echocardiographic examination before and 3 months after surgery. At 3 months after surgery, BMI and systolic blood pressure (BP) decreased (43.3 ± 6.3 to 34.1 ± 5.6 kg/m2, P < 0.001, and 146 ± 12 to 130 ± 14 mm Hg, P < 0.001, respectively). In left ventricular (LV) geometry, the relative wall thickness (RWT) and LV mass index decreased significantly (0.43 ± 0.05 to 0.35 ± 0.05, P < 0.001, and 50 ± 11 to 39 ± 11 g/m2.7, P < 0.001, respectively) without changes in chamber size. Multivariate analyses showed change in systolic BP to be an independent predictor for the changes in RWT and LV mass index. In myocardial performance, peak systolic mitral annular velocity and all diastolic indexes showed significant improvements. We concluded that LV hypertrophy and function improved rapidly after bariatric surgery in severely obese adults. BP reduction was the major determinant for the regression of LV hypertrophy in the early stage of surgical weight reduction. |
| doi_str_mv | 10.1038/oby.2010.42 |
| format | Article |
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Sixty-six severely obese adults (BMI ≥35 kg/m2) who received bariatric surgery underwent echocardiographic examination before and 3 months after surgery. At 3 months after surgery, BMI and systolic blood pressure (BP) decreased (43.3 ± 6.3 to 34.1 ± 5.6 kg/m2, P < 0.001, and 146 ± 12 to 130 ± 14 mm Hg, P < 0.001, respectively). In left ventricular (LV) geometry, the relative wall thickness (RWT) and LV mass index decreased significantly (0.43 ± 0.05 to 0.35 ± 0.05, P < 0.001, and 50 ± 11 to 39 ± 11 g/m2.7, P < 0.001, respectively) without changes in chamber size. Multivariate analyses showed change in systolic BP to be an independent predictor for the changes in RWT and LV mass index. In myocardial performance, peak systolic mitral annular velocity and all diastolic indexes showed significant improvements. We concluded that LV hypertrophy and function improved rapidly after bariatric surgery in severely obese adults. BP reduction was the major determinant for the regression of LV hypertrophy in the early stage of surgical weight reduction.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1038/oby.2010.42</identifier><identifier>PMID: 20300087</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; adults ; bariatric surgery ; Bariatric Surgery - rehabilitation ; Blood Pressure - physiology ; body mass index ; Body Weight - physiology ; Echocardiography ; Electrocardiography ; Female ; Heart Rate - physiology ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - pathology ; Heart Ventricles - physiopathology ; Humans ; hypertrophy ; Male ; Middle Aged ; multivariate analysis ; obesity ; Obesity, Morbid - pathology ; Obesity, Morbid - physiopathology ; Obesity, Morbid - rehabilitation ; Obesity, Morbid - surgery ; systolic blood pressure ; Ventricular Function, Left ; weight loss ; Weight Loss - physiology ; Young Adult</subject><ispartof>Obesity (Silver Spring, Md.), 2010-06, Vol.18 (6), p.1188-1193</ispartof><rights>2010 North American Association for the Study of Obesity (NAASO)</rights><rights>Copyright Nature Publishing Group Jun 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4424-4de6f3b3c9c84c416ee7de009fa6a49e0b8c735597c4b9a129b839bffe83ebd63</citedby><cites>FETCH-LOGICAL-c4424-4de6f3b3c9c84c416ee7de009fa6a49e0b8c735597c4b9a129b839bffe83ebd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2010.42$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2010.42$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20300087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsuan, Chin-Feng</creatorcontrib><creatorcontrib>Huang, Chih-Kun</creatorcontrib><creatorcontrib>Lin, Jou-Wei</creatorcontrib><creatorcontrib>Lin, Lung-Chun</creatorcontrib><creatorcontrib>Lee, Thung-Lip</creatorcontrib><creatorcontrib>Tai, Chi-Ming</creatorcontrib><creatorcontrib>Yin, Wei-Hsian</creatorcontrib><creatorcontrib>Tseng, Wei-Kung</creatorcontrib><creatorcontrib>Hsu, Kwan-Lih</creatorcontrib><creatorcontrib>Wu, Chau-Chung</creatorcontrib><title>Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>The aim of this study was to examine the effect of surgical weight reduction on cardiac structure and function and to seek the determinants of these changes. Sixty-six severely obese adults (BMI ≥35 kg/m2) who received bariatric surgery underwent echocardiographic examination before and 3 months after surgery. At 3 months after surgery, BMI and systolic blood pressure (BP) decreased (43.3 ± 6.3 to 34.1 ± 5.6 kg/m2, P < 0.001, and 146 ± 12 to 130 ± 14 mm Hg, P < 0.001, respectively). In left ventricular (LV) geometry, the relative wall thickness (RWT) and LV mass index decreased significantly (0.43 ± 0.05 to 0.35 ± 0.05, P < 0.001, and 50 ± 11 to 39 ± 11 g/m2.7, P < 0.001, respectively) without changes in chamber size. Multivariate analyses showed change in systolic BP to be an independent predictor for the changes in RWT and LV mass index. In myocardial performance, peak systolic mitral annular velocity and all diastolic indexes showed significant improvements. We concluded that LV hypertrophy and function improved rapidly after bariatric surgery in severely obese adults. BP reduction was the major determinant for the regression of LV hypertrophy in the early stage of surgical weight reduction.</description><subject>Adult</subject><subject>adults</subject><subject>bariatric surgery</subject><subject>Bariatric Surgery - rehabilitation</subject><subject>Blood Pressure - physiology</subject><subject>body mass index</subject><subject>Body Weight - physiology</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - pathology</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>hypertrophy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multivariate analysis</subject><subject>obesity</subject><subject>Obesity, Morbid - pathology</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - rehabilitation</subject><subject>Obesity, Morbid - surgery</subject><subject>systolic blood pressure</subject><subject>Ventricular Function, Left</subject><subject>weight loss</subject><subject>Weight Loss - physiology</subject><subject>Young Adult</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1v1DAQxS0EoqVw4g6WOHBAW8ax17GPpWoBaaWVWMrHydjOZHGVTYodg_a_xyHLHjggWbLH83tvRo-QpwzOGXD1enD78wpKJap75JRpDoua6y_3j2_FTsijlG4BhIQle0hOKuAAoOpT8u2qbdGPdGjpJsdt8LajnzFsv4_0AzbZj2HoaTkrbEf6CfsxBp87G-lmjKWbI1LbN_Q69zMaerrBn1i-1w5TGPePyYPWdgmfHO4zcnN99fHy3WK1fvv-8mK18EJUYiEalC133GuvhBdMItYNAujWSis0glO-5sulrr1w2rJKO8W1K8srjq6R_Iy8nH3v4vAjYxrNLiSPXWd7HHIyNecMJIeqkC_-IW-HHPuynCl5QqVqgGWhXs2Uj0NKEVtzF8POxn2BJk6ZkruZcjdi8nx28Mxuh82R_Rt0AWAGfoUO9__zMus3X1ktRZE8nyW9nXI-ago7oX-mHojWDsZuY0jmZlN6ssysJVOa_wYNuqDm</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Hsuan, Chin-Feng</creator><creator>Huang, Chih-Kun</creator><creator>Lin, Jou-Wei</creator><creator>Lin, Lung-Chun</creator><creator>Lee, Thung-Lip</creator><creator>Tai, Chi-Ming</creator><creator>Yin, Wei-Hsian</creator><creator>Tseng, Wei-Kung</creator><creator>Hsu, Kwan-Lih</creator><creator>Wu, Chau-Chung</creator><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201006</creationdate><title>Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity</title><author>Hsuan, Chin-Feng ; Huang, Chih-Kun ; Lin, Jou-Wei ; Lin, Lung-Chun ; Lee, Thung-Lip ; Tai, Chi-Ming ; Yin, Wei-Hsian ; Tseng, Wei-Kung ; Hsu, Kwan-Lih ; Wu, Chau-Chung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4424-4de6f3b3c9c84c416ee7de009fa6a49e0b8c735597c4b9a129b839bffe83ebd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>adults</topic><topic>bariatric surgery</topic><topic>Bariatric Surgery - rehabilitation</topic><topic>Blood Pressure - physiology</topic><topic>body mass index</topic><topic>Body Weight - physiology</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - pathology</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>hypertrophy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multivariate analysis</topic><topic>obesity</topic><topic>Obesity, Morbid - pathology</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - rehabilitation</topic><topic>Obesity, Morbid - surgery</topic><topic>systolic blood pressure</topic><topic>Ventricular Function, Left</topic><topic>weight loss</topic><topic>Weight Loss - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsuan, Chin-Feng</creatorcontrib><creatorcontrib>Huang, Chih-Kun</creatorcontrib><creatorcontrib>Lin, Jou-Wei</creatorcontrib><creatorcontrib>Lin, Lung-Chun</creatorcontrib><creatorcontrib>Lee, Thung-Lip</creatorcontrib><creatorcontrib>Tai, Chi-Ming</creatorcontrib><creatorcontrib>Yin, Wei-Hsian</creatorcontrib><creatorcontrib>Tseng, Wei-Kung</creatorcontrib><creatorcontrib>Hsu, Kwan-Lih</creatorcontrib><creatorcontrib>Wu, Chau-Chung</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsuan, Chin-Feng</au><au>Huang, Chih-Kun</au><au>Lin, Jou-Wei</au><au>Lin, Lung-Chun</au><au>Lee, Thung-Lip</au><au>Tai, Chi-Ming</au><au>Yin, Wei-Hsian</au><au>Tseng, Wei-Kung</au><au>Hsu, Kwan-Lih</au><au>Wu, Chau-Chung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2010-06</date><risdate>2010</risdate><volume>18</volume><issue>6</issue><spage>1188</spage><epage>1193</epage><pages>1188-1193</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>The aim of this study was to examine the effect of surgical weight reduction on cardiac structure and function and to seek the determinants of these changes. Sixty-six severely obese adults (BMI ≥35 kg/m2) who received bariatric surgery underwent echocardiographic examination before and 3 months after surgery. At 3 months after surgery, BMI and systolic blood pressure (BP) decreased (43.3 ± 6.3 to 34.1 ± 5.6 kg/m2, P < 0.001, and 146 ± 12 to 130 ± 14 mm Hg, P < 0.001, respectively). In left ventricular (LV) geometry, the relative wall thickness (RWT) and LV mass index decreased significantly (0.43 ± 0.05 to 0.35 ± 0.05, P < 0.001, and 50 ± 11 to 39 ± 11 g/m2.7, P < 0.001, respectively) without changes in chamber size. Multivariate analyses showed change in systolic BP to be an independent predictor for the changes in RWT and LV mass index. In myocardial performance, peak systolic mitral annular velocity and all diastolic indexes showed significant improvements. We concluded that LV hypertrophy and function improved rapidly after bariatric surgery in severely obese adults. BP reduction was the major determinant for the regression of LV hypertrophy in the early stage of surgical weight reduction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20300087</pmid><doi>10.1038/oby.2010.42</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult adults bariatric surgery Bariatric Surgery - rehabilitation Blood Pressure - physiology body mass index Body Weight - physiology Echocardiography Electrocardiography Female Heart Rate - physiology Heart Ventricles - diagnostic imaging Heart Ventricles - pathology Heart Ventricles - physiopathology Humans hypertrophy Male Middle Aged multivariate analysis obesity Obesity, Morbid - pathology Obesity, Morbid - physiopathology Obesity, Morbid - rehabilitation Obesity, Morbid - surgery systolic blood pressure Ventricular Function, Left weight loss Weight Loss - physiology Young Adult |
| title | Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity |
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