Comparison of Prognostic Factors and Survival Among Black Patients and White Patients Treated With Irradiation for Non-Small-Cell Lung Cancer
Background: Many studies have reported differences in cancer incidence and survival between populations of Blacks and Whites. A 45% higher death rate from lung cancer for Black men and a survival duration for Black patients with lung cancer that is generally shorter than that for White patients have...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1992-11, Vol.84 (22), p.1731-1735 |
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| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 84 |
| creator | Graham, Mary V. Geitz, Lynne M. Byhardt, Roger Asbell, Sucha Roach, Mack Urtasun, Raul C. Curran, Walter J. Lattin, Paul Russell, Anthony H. Cox, James D. |
| description | Background: Many studies have reported differences in cancer incidence and survival between populations of Blacks and Whites. A 45% higher death rate from lung cancer for Black men and a survival duration for Black patients with lung cancer that is generally shorter than that for White patients have also been reported. Purpose: The purpose of this study was to evaluate whether race affects known prognostic factors for non—small-cell lung cancer in Black versus White patients. This analysis attempts to determine which prognostic factors may contribute to the reported differences in disease outcome. Methods: We used data from 1565 patients with non—small-cell lung cancer treated in four randomized prospective trials conducted by the Radiation Therapy Oncology Group (RTOG). The data were pooled for a retrospective analysis of survival and prognostic factors by race. Results: Univariate analysis showed significant differences between Blacks and Whites with regard to sex, weight loss, histology, and RTOG T stage (P |
| doi_str_mv | 10.1093/jnci/84.22.1731 |
| format | Article |
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A 45% higher death rate from lung cancer for Black men and a survival duration for Black patients with lung cancer that is generally shorter than that for White patients have also been reported. Purpose: The purpose of this study was to evaluate whether race affects known prognostic factors for non—small-cell lung cancer in Black versus White patients. This analysis attempts to determine which prognostic factors may contribute to the reported differences in disease outcome. Methods: We used data from 1565 patients with non—small-cell lung cancer treated in four randomized prospective trials conducted by the Radiation Therapy Oncology Group (RTOG). The data were pooled for a retrospective analysis of survival and prognostic factors by race. Results: Univariate analysis showed significant differences between Blacks and Whites with regard to sex, weight loss, histology, and RTOG T stage (P<.05), but the only clinically significant difference (P≤.01) was weight loss. Despite these findings, overall survival for Blacks and Whites did not differ significantly (P = .67). Median survival for Blacks and Whites with a Karnofsky performance status (KPS) of 90 or more was 12.1 and 11.3 months, respectively (P =.45). Survival for Blacks and Whites with a KPS of less than 90 was 7.8 and 6.8 months, respectively. Cause of death did not differ between the two races. For both races, KPS, age, sex, weight loss, and RTOG T and N stages were significant prognostic factors for survival (P<.01), but race was not a significant prognostic factor. Conclusion: Further studies of the differential in cancer survival for Blacks and Whites may be indicated, but greater impact may be achieved by addressing socioeconomic factors, lifestyle and occupational risk factors, health education, and access to adequate health care. [J Natl Cancer Inst 84: 1731–1735, 1992]</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/84.22.1731</identifier><identifier>PMID: 1331484</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>African Continental Ancestry Group ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - radiotherapy ; European Continental Ancestry Group ; Humans ; Lung Neoplasms - radiotherapy ; Medical sciences ; Pneumology ; Prognosis ; Prospective Studies ; Survival Analysis ; Tumors of the respiratory system and mediastinum</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1992-11, Vol.84 (22), p.1731-1735</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-3365bd21e7c31de861fa2795cfc15483ecb56515cba46f2d95df533bf88f85973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4519859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1331484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graham, Mary V.</creatorcontrib><creatorcontrib>Geitz, Lynne M.</creatorcontrib><creatorcontrib>Byhardt, Roger</creatorcontrib><creatorcontrib>Asbell, Sucha</creatorcontrib><creatorcontrib>Roach, Mack</creatorcontrib><creatorcontrib>Urtasun, Raul C.</creatorcontrib><creatorcontrib>Curran, Walter J.</creatorcontrib><creatorcontrib>Lattin, Paul</creatorcontrib><creatorcontrib>Russell, Anthony H.</creatorcontrib><creatorcontrib>Cox, James D.</creatorcontrib><title>Comparison of Prognostic Factors and Survival Among Black Patients and White Patients Treated With Irradiation for Non-Small-Cell Lung Cancer</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>Background: Many studies have reported differences in cancer incidence and survival between populations of Blacks and Whites. A 45% higher death rate from lung cancer for Black men and a survival duration for Black patients with lung cancer that is generally shorter than that for White patients have also been reported. Purpose: The purpose of this study was to evaluate whether race affects known prognostic factors for non—small-cell lung cancer in Black versus White patients. This analysis attempts to determine which prognostic factors may contribute to the reported differences in disease outcome. Methods: We used data from 1565 patients with non—small-cell lung cancer treated in four randomized prospective trials conducted by the Radiation Therapy Oncology Group (RTOG). The data were pooled for a retrospective analysis of survival and prognostic factors by race. Results: Univariate analysis showed significant differences between Blacks and Whites with regard to sex, weight loss, histology, and RTOG T stage (P<.05), but the only clinically significant difference (P≤.01) was weight loss. Despite these findings, overall survival for Blacks and Whites did not differ significantly (P = .67). Median survival for Blacks and Whites with a Karnofsky performance status (KPS) of 90 or more was 12.1 and 11.3 months, respectively (P =.45). Survival for Blacks and Whites with a KPS of less than 90 was 7.8 and 6.8 months, respectively. Cause of death did not differ between the two races. For both races, KPS, age, sex, weight loss, and RTOG T and N stages were significant prognostic factors for survival (P<.01), but race was not a significant prognostic factor. Conclusion: Further studies of the differential in cancer survival for Blacks and Whites may be indicated, but greater impact may be achieved by addressing socioeconomic factors, lifestyle and occupational risk factors, health education, and access to adequate health care. [J Natl Cancer Inst 84: 1731–1735, 1992]</description><subject>African Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - radiotherapy</subject><subject>European Continental Ancestry Group</subject><subject>Humans</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Survival Analysis</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtr3DAUhUVpSadp110VtCjdecZ6WfIyNc0DhjQwUxKyEbIsJUpsayLJof0R_c_R4CHRRnDPp3Ov7gHgKyqXqKzJ6mHUbiXoEuMl4gS9AwtEq7LAqGTvwaIsMS-E4PQj-BTjQ5lPjekROEKEICroAvxv_LBTwUU_Qm_hVfB3o4_JaXiqdPIhQjV2cDOFZ_esengy-PEO_uyVfoRXKjkzppm4vnfJvJW2wahkctmle3gRgupclnIP6wO89GOxGVTfF43pe7iesmWjRm3CZ_DBqj6aL4f7GPw5_bVtzov177OL5mRdaMLqVBBSsbbDyHBNUGdEhazCvGbaasSoIEa3rGKI6VbRyuKuZp1lhLRWCCtYzckx-DH77oJ_mkxMcnBR52HUaPwUJc_rKRnFGVzNoA4-xmCs3AU3qPBPolLuA5D7AKSgEmO5DyC_-HawntrBdG_8vPGsfz_oKmrV25A_7uIrRhmq84gZK2bMxWT-vsoqPMqKE87k-c2tPNsSvkE1lTfkBceVnuU</recordid><startdate>19921118</startdate><enddate>19921118</enddate><creator>Graham, Mary V.</creator><creator>Geitz, Lynne M.</creator><creator>Byhardt, Roger</creator><creator>Asbell, Sucha</creator><creator>Roach, Mack</creator><creator>Urtasun, Raul C.</creator><creator>Curran, Walter J.</creator><creator>Lattin, Paul</creator><creator>Russell, Anthony H.</creator><creator>Cox, James D.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19921118</creationdate><title>Comparison of Prognostic Factors and Survival Among Black Patients and White Patients Treated With Irradiation for Non-Small-Cell Lung Cancer</title><author>Graham, Mary V. ; Geitz, Lynne M. ; Byhardt, Roger ; Asbell, Sucha ; Roach, Mack ; Urtasun, Raul C. ; Curran, Walter J. ; Lattin, Paul ; Russell, Anthony H. ; Cox, James D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-3365bd21e7c31de861fa2795cfc15483ecb56515cba46f2d95df533bf88f85973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>African Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - radiotherapy</topic><topic>European Continental Ancestry Group</topic><topic>Humans</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Survival Analysis</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graham, Mary V.</creatorcontrib><creatorcontrib>Geitz, Lynne M.</creatorcontrib><creatorcontrib>Byhardt, Roger</creatorcontrib><creatorcontrib>Asbell, Sucha</creatorcontrib><creatorcontrib>Roach, Mack</creatorcontrib><creatorcontrib>Urtasun, Raul C.</creatorcontrib><creatorcontrib>Curran, Walter J.</creatorcontrib><creatorcontrib>Lattin, Paul</creatorcontrib><creatorcontrib>Russell, Anthony H.</creatorcontrib><creatorcontrib>Cox, James D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graham, Mary V.</au><au>Geitz, Lynne M.</au><au>Byhardt, Roger</au><au>Asbell, Sucha</au><au>Roach, Mack</au><au>Urtasun, Raul C.</au><au>Curran, Walter J.</au><au>Lattin, Paul</au><au>Russell, Anthony H.</au><au>Cox, James D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Prognostic Factors and Survival Among Black Patients and White Patients Treated With Irradiation for Non-Small-Cell Lung Cancer</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>1992-11-18</date><risdate>1992</risdate><volume>84</volume><issue>22</issue><spage>1731</spage><epage>1735</epage><pages>1731-1735</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Background: Many studies have reported differences in cancer incidence and survival between populations of Blacks and Whites. A 45% higher death rate from lung cancer for Black men and a survival duration for Black patients with lung cancer that is generally shorter than that for White patients have also been reported. Purpose: The purpose of this study was to evaluate whether race affects known prognostic factors for non—small-cell lung cancer in Black versus White patients. This analysis attempts to determine which prognostic factors may contribute to the reported differences in disease outcome. Methods: We used data from 1565 patients with non—small-cell lung cancer treated in four randomized prospective trials conducted by the Radiation Therapy Oncology Group (RTOG). The data were pooled for a retrospective analysis of survival and prognostic factors by race. Results: Univariate analysis showed significant differences between Blacks and Whites with regard to sex, weight loss, histology, and RTOG T stage (P<.05), but the only clinically significant difference (P≤.01) was weight loss. Despite these findings, overall survival for Blacks and Whites did not differ significantly (P = .67). Median survival for Blacks and Whites with a Karnofsky performance status (KPS) of 90 or more was 12.1 and 11.3 months, respectively (P =.45). Survival for Blacks and Whites with a KPS of less than 90 was 7.8 and 6.8 months, respectively. Cause of death did not differ between the two races. For both races, KPS, age, sex, weight loss, and RTOG T and N stages were significant prognostic factors for survival (P<.01), but race was not a significant prognostic factor. Conclusion: Further studies of the differential in cancer survival for Blacks and Whites may be indicated, but greater impact may be achieved by addressing socioeconomic factors, lifestyle and occupational risk factors, health education, and access to adequate health care. [J Natl Cancer Inst 84: 1731–1735, 1992]</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>1331484</pmid><doi>10.1093/jnci/84.22.1731</doi><tpages>5</tpages></addata></record> |
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| subjects | African Continental Ancestry Group Biological and medical sciences Carcinoma, Non-Small-Cell Lung - radiotherapy European Continental Ancestry Group Humans Lung Neoplasms - radiotherapy Medical sciences Pneumology Prognosis Prospective Studies Survival Analysis Tumors of the respiratory system and mediastinum |
| title | Comparison of Prognostic Factors and Survival Among Black Patients and White Patients Treated With Irradiation for Non-Small-Cell Lung Cancer |
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