Exo1: A New Chemical Inhibitor of the Exocytic Pathway

A phenotypic screen was used to search for drug-like molecules that can interfere with specific steps in membrane traffic. 2-(4-Fluorobenzoylamino)-benzoic acid methyl ester (Exo1), identified in this screen, induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus acutely inhibiting...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-05, Vol.100 (11), p.6469-6474
Hauptverfasser:	Feng, Yan, Yu, Sidney, Troy K. R. Lasell, Jadhav, Ashutosh P., Macia, Eric, Chardin, Pierre, Melancon, Paul, Roth, Michael, Mitchison, Timothy, Kirchhausen, Tomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Ribose - metabolism Benzamides - chemistry Benzamides - pharmacology Benzoates - chemistry Benzoates - pharmacology Biological Sciences Biological transport Brefeldin A - pharmacology Cell division Cell Line Cell membranes Chemicals Endosomes Eukaryotes Exocytosis Fluorescence Golgi apparatus Golgi Apparatus - metabolism Guanine Nucleotide Exchange Factors - metabolism Hydrolysis Microscopy, Fluorescence Molecules Organelles P branes Phenotype Traffic
Online-Zugang:	Volltext
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