Relationship Between Platelet Monoamine Oxidase B Activity and Alleles at the MAOB Locus
: Genetic variations in monoamine oxidase (MAO)‐B activity have been proposed to have a contributory role in several neurologic and psychiatric diseases. Variations in activity could affect rates of degradation of exogenous amines, including toxins, precursors of toxins (like 1‐methyl‐4‐phenyl‐1,2,3...
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| Veröffentlicht in: | Journal of neurochemistry 1992-12, Vol.59 (6), p.2063-2066 |
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| container_issue | 6 |
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| container_title | Journal of neurochemistry |
| container_volume | 59 |
| creator | Girmen, A. Sule Baenziger, John Hotamisligil, Gokhan S. Konradi, Christine Shalish, Christo Sullivan, Jack L. Breakefield, Xandra O. |
| description | : Genetic variations in monoamine oxidase (MAO)‐B activity have been proposed to have a contributory role in several neurologic and psychiatric diseases. Variations in activity could affect rates of degradation of exogenous amines, including toxins, precursors of toxins (like 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine), or false transmitters, and of endogenous amines, such as neurotransmitters. In this study a highly polymorphic (GT)n repeat element was used to mark alleles at the MAOB locus. The MAOB allele status and levels of platelet MAO‐B activity were determined for 41 control males. No correlation was noted between specific alleles and levels of MAO‐B activity in this sample set. This suggests that the structural gene for MAOB is not usually the primary determinant of activity levels in platelets. |
| doi_str_mv | 10.1111/j.1471-4159.1992.tb10095.x |
| format | Article |
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Sule ; Baenziger, John ; Hotamisligil, Gokhan S. ; Konradi, Christine ; Shalish, Christo ; Sullivan, Jack L. ; Breakefield, Xandra O.</creator><creatorcontrib>Girmen, A. Sule ; Baenziger, John ; Hotamisligil, Gokhan S. ; Konradi, Christine ; Shalish, Christo ; Sullivan, Jack L. ; Breakefield, Xandra O.</creatorcontrib><description>: Genetic variations in monoamine oxidase (MAO)‐B activity have been proposed to have a contributory role in several neurologic and psychiatric diseases. Variations in activity could affect rates of degradation of exogenous amines, including toxins, precursors of toxins (like 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine), or false transmitters, and of endogenous amines, such as neurotransmitters. In this study a highly polymorphic (GT)n repeat element was used to mark alleles at the MAOB locus. The MAOB allele status and levels of platelet MAO‐B activity were determined for 41 control males. No correlation was noted between specific alleles and levels of MAO‐B activity in this sample set. This suggests that the structural gene for MAOB is not usually the primary determinant of activity levels in platelets.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1992.tb10095.x</identifier><identifier>PMID: 1431894</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Alleles ; Base Sequence ; Biological and medical sciences ; Blood Platelets - enzymology ; Chromosome Mapping ; Enzyme Activation ; Fundamental and applied biological sciences. Psychology ; Genetic Variation ; GT‐repeat element ; Human ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Monoamine Oxidase - blood ; Monoamine Oxidase - genetics ; Monoamine oxidase A ; Monoamine oxidase B ; Platelets ; Polymorphism, Genetic ; Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><ispartof>Journal of neurochemistry, 1992-12, Vol.59 (6), p.2063-2066</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3993-29c960ae31e89a3a1fbc3a2581c0c4e1edf0756cf826affa6e8b917f62e9cf583</citedby><cites>FETCH-LOGICAL-c3993-29c960ae31e89a3a1fbc3a2581c0c4e1edf0756cf826affa6e8b917f62e9cf583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1992.tb10095.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1992.tb10095.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4448054$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1431894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Girmen, A. Sule</creatorcontrib><creatorcontrib>Baenziger, John</creatorcontrib><creatorcontrib>Hotamisligil, Gokhan S.</creatorcontrib><creatorcontrib>Konradi, Christine</creatorcontrib><creatorcontrib>Shalish, Christo</creatorcontrib><creatorcontrib>Sullivan, Jack L.</creatorcontrib><creatorcontrib>Breakefield, Xandra O.</creatorcontrib><title>Relationship Between Platelet Monoamine Oxidase B Activity and Alleles at the MAOB Locus</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Genetic variations in monoamine oxidase (MAO)‐B activity have been proposed to have a contributory role in several neurologic and psychiatric diseases. Variations in activity could affect rates of degradation of exogenous amines, including toxins, precursors of toxins (like 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine), or false transmitters, and of endogenous amines, such as neurotransmitters. In this study a highly polymorphic (GT)n repeat element was used to mark alleles at the MAOB locus. The MAOB allele status and levels of platelet MAO‐B activity were determined for 41 control males. No correlation was noted between specific alleles and levels of MAO‐B activity in this sample set. This suggests that the structural gene for MAOB is not usually the primary determinant of activity levels in platelets.</description><subject>Adult</subject><subject>Alleles</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - enzymology</subject><subject>Chromosome Mapping</subject><subject>Enzyme Activation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation</subject><subject>GT‐repeat element</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Monoamine Oxidase - blood</subject><subject>Monoamine Oxidase - genetics</subject><subject>Monoamine oxidase A</subject><subject>Monoamine oxidase B</subject><subject>Platelets</subject><subject>Polymorphism, Genetic</subject><subject>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkN-LEzEQx4MoZz39E4Qg4tuumSS73fgibfEnPSui4FuYphMuJd3tbVKv_e_dpeV8dl4G5vuZSfgw9gpECUO93Zagp1BoqEwJxsgyr0EIU5XHR2zyED1mEyGkLJTQ8il7ltJWCKh1DVfsCrSCxugJ-_2DIubQtek27Pmc8j1Ry78PM4qU-U3XdrgLLfHVMWwwEZ_zmcvhT8gnju2Gz2IcwMQx83xL_Ga2mvNl5w7pOXviMSZ6cenX7NfHDz8Xn4vl6tOXxWxZOGWMKqRxphZICqgxqBD82imUVQNOOE1AGy-mVe18I2v0Hmtq1gamvpZknK8adc3enO_u--7uQCnbXUiOYsSWukOyU6VAKAED-O4Mur5LqSdv933YYX-yIOyo1W7t6M6O7uyo1V602uOw_PLyymG9o82_1bPHIX99yTE5jL7H1oX0gGmtG1GN2Pszdh8inf7jA_brt4UUtVJ_AVxLlFU</recordid><startdate>199212</startdate><enddate>199212</enddate><creator>Girmen, A. Sule</creator><creator>Baenziger, John</creator><creator>Hotamisligil, Gokhan S.</creator><creator>Konradi, Christine</creator><creator>Shalish, Christo</creator><creator>Sullivan, Jack L.</creator><creator>Breakefield, Xandra O.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199212</creationdate><title>Relationship Between Platelet Monoamine Oxidase B Activity and Alleles at the MAOB Locus</title><author>Girmen, A. Sule ; Baenziger, John ; Hotamisligil, Gokhan S. ; Konradi, Christine ; Shalish, Christo ; Sullivan, Jack L. ; Breakefield, Xandra O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3993-29c960ae31e89a3a1fbc3a2581c0c4e1edf0756cf826affa6e8b917f62e9cf583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - enzymology</topic><topic>Chromosome Mapping</topic><topic>Enzyme Activation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Variation</topic><topic>GT‐repeat element</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Monoamine Oxidase - blood</topic><topic>Monoamine Oxidase - genetics</topic><topic>Monoamine oxidase A</topic><topic>Monoamine oxidase B</topic><topic>Platelets</topic><topic>Polymorphism, Genetic</topic><topic>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Girmen, A. Sule</creatorcontrib><creatorcontrib>Baenziger, John</creatorcontrib><creatorcontrib>Hotamisligil, Gokhan S.</creatorcontrib><creatorcontrib>Konradi, Christine</creatorcontrib><creatorcontrib>Shalish, Christo</creatorcontrib><creatorcontrib>Sullivan, Jack L.</creatorcontrib><creatorcontrib>Breakefield, Xandra O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Girmen, A. Sule</au><au>Baenziger, John</au><au>Hotamisligil, Gokhan S.</au><au>Konradi, Christine</au><au>Shalish, Christo</au><au>Sullivan, Jack L.</au><au>Breakefield, Xandra O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between Platelet Monoamine Oxidase B Activity and Alleles at the MAOB Locus</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1992-12</date><risdate>1992</risdate><volume>59</volume><issue>6</issue><spage>2063</spage><epage>2066</epage><pages>2063-2066</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Genetic variations in monoamine oxidase (MAO)‐B activity have been proposed to have a contributory role in several neurologic and psychiatric diseases. Variations in activity could affect rates of degradation of exogenous amines, including toxins, precursors of toxins (like 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine), or false transmitters, and of endogenous amines, such as neurotransmitters. In this study a highly polymorphic (GT)n repeat element was used to mark alleles at the MAOB locus. The MAOB allele status and levels of platelet MAO‐B activity were determined for 41 control males. No correlation was noted between specific alleles and levels of MAO‐B activity in this sample set. This suggests that the structural gene for MAOB is not usually the primary determinant of activity levels in platelets.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1431894</pmid><doi>10.1111/j.1471-4159.1992.tb10095.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of neurochemistry, 1992-12, Vol.59 (6), p.2063-2066 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Alleles Base Sequence Biological and medical sciences Blood Platelets - enzymology Chromosome Mapping Enzyme Activation Fundamental and applied biological sciences. Psychology Genetic Variation GT‐repeat element Human Humans Male Middle Aged Molecular Sequence Data Monoamine Oxidase - blood Monoamine Oxidase - genetics Monoamine oxidase A Monoamine oxidase B Platelets Polymorphism, Genetic Vertebrates: blood, hematopoietic organs, reticuloendothelial system |
| title | Relationship Between Platelet Monoamine Oxidase B Activity and Alleles at the MAOB Locus |
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